Ctsb - cathepsin B Gene

Also Known as CB

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13030

About Ctsb

Chromosome 14: 63,359,911-63,383,372 forward strand.GRCm39:CM001007.3

This gene has 3 transcripts (splice variants), 223 orthologues, 24 paralogues and is associated with 9 phenotypes. Ubiquitous expression in adrenal adult (RPKM 374.9), subcutaneous fat pad adult (RPKM 322.2) and 26 other tissues.

Summary

This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the Cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte Apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]

Ctsb Products (1)

mRNA Protein Name
NM_007798.3 NP_031824.1 cathepsin B preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
30487519 MGI
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
28728022 MGI
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
28835281 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within decidualization IGI
IGI: Inferred from genetic interaction
9310336 MGI
involved in proteolysis involved in protein catabolic process IMP
IMP: Inferred from mutant phenotype
12782676 MGI
involved in symbiont entry into host cell IMP
IMP: Inferred from mutant phenotype
15831716 MGI
involved in thyroid hormone generation IMP
IMP: Inferred from mutant phenotype
12782676 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
12782676 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
12782676 MGI
located in lysosome IDA
IDA: Inferred from direct assay
9034150 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsb Protein Structure

Propeptide_C1

Propeptide_C1: pfam08127 (25 - 64)

Peptidase_C1A_CathepsinB

Peptidase_C1A_CathepsinB: cd02620 (80 - 327)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

cathepsin B

  • cathepsin B1

Recombinant Ctsb Proteins

Cat. No. Product Name Accession Purity
HY-P7747 Cathepsin B Protein, Mouse (HEK293, His) P10605 (H18-F339) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-178820 NM-002 / Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119293 K777 Inhibitor 99.14% Unkown
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-RS03322 CTSB Human Pre-designed siRNA Set A / Unkown
HY-119293A K777 tosylate Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-178819 NM-001 / Unkown
HY-184662 Ferroptosis inducer-17 / Unkown
HY-RS03323 Ctsb Mouse Pre-designed siRNA Set A / Unkown
HY-RS03324 Ctsb Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsb NCBI NCBI:1508