2. Gene
  3. Ctsb - cathepsin B Gene

Ctsb - cathepsin B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CB

Gene ID: 13030 | Gene type: protein coding

About Ctsb

Chromosome 14: 63,359,911-63,383,372 forward strand.GRCm39:CM001007.3

This gene has 3 transcripts (splice variants), 223 orthologues, 24 paralogues and is associated with 9 phenotypes. Ubiquitous expression in adrenal adult (RPKM 374.9), subcutaneous fat pad adult (RPKM 322.2) and 26 other tissues.

Summary

This gene encodes a member of the peptidase C1 family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the Cathepsin B light and heavy chains, which can dimerize to generate the double chain form of the Enzyme. This Enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. Homozygous knockout mice for this gene exhibit reduced pancreatic damage following induced pancreatitis and reduced hepatocyte Apoptosis in a model of liver injury. Pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Aug 2015]

Ctsb Products(1)

mRNA Protein Name
NM_007798.3 NP_031824.1 cathepsin B preproprotein

Ctsb Protein Structure

Propeptide_C1

Propeptide_C1: pfam08127 (25 - 64)

Peptidase_C1A_CathepsinB

Peptidase_C1A_CathepsinB: cd02620 (80 - 327)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
Protein Preferred Names Protein Names

cathepsin B

cathepsin B1

Recombinant Ctsb Proteins

Cat. No. Product Name Accession Purity
HY-P7747 Cathepsin B Protein, Mouse (HEK293, His) P10605 (H18-F339) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride Inhibitor 98.29% Phase 2
HY-137978 Ezurpimtrostat Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119293 K777 99.77% Unkown
HY-RS03322 CTSB Human Pre-designed siRNA Set A / Unkown
HY-RS03323 Ctsb Mouse Pre-designed siRNA Set A / Unkown
HY-RS03324 Ctsb Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsb NCBI NCBI:1508
Rattus norvegicus Ctsb NCBI NCBI:64529