ADM - adrenomedullin Gene
Also Known as AM; PAMP
Species: Homo sapiens
About ADM
This gene has 8 transcripts (splice variants), 185 orthologues and 1 paralogue. Broad expression in placenta (RPKM 66.2), fat (RPKM 27.8) and 18 other tissues.
Summary
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, Adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is Antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014]
ADM Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001124.3 | NP_001115.1 | pro-adrenomedullin precursor |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables adrenomedullin receptor binding |
IDA
IDA: Inferred from direct assay
|
20074556 | GOA |
| Cellular Component GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
12379507 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
10225288 | GOA |
ADM Protein Structure
Calc_CGRP_IAPP: Calcitonin / CGRP / IAPP family (1 - 153)
- 0
- 100
- 185 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
pro-adrenomedullin |
|
Recombinant ADM Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P74426 | Adrenomedullin/ADM Protein, Human (HEK293, Fc) | P35318 (Y95-Y146) | ≥ 90%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pheochromocytoma |
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| Malignant Hypertension |
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| Pulmonary Hypertension |
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| Congestive Heart Failure |
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| Renal Hypertension |
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| Ganglioneuroblastoma |
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| Capillary Leak Syndrome |
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| Heart Disease |
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| Renovascular Hypertension |
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| Kawasaki Disease |
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| Vitreoretinopathy, Neovascular Inflammatory |
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| Kidney Disease |
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| Hypertension, Essential |
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| Acute Myocardial Infarction |
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| Liver Cirrhosis |
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| Oligohydramnios |
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| Ischemia |
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| Pre-Eclampsia |
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| Pneumonia |
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| Pyelonephritis |
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| Diabetic Angiopathy |
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| Neurofibroma |
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| Myocardial Infarction |
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| Intracranial Berry Aneurysm |
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| Adrenal Adenoma |
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| Hellp Syndrome |
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| Cardiovascular System Disease |
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| Lung Disease |
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| Conn'S Syndrome |
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| Microvascular Complications Of Diabetes 1 |
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| Macular Holes |
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| Tetralogy Of Fallot |
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| Adrenal Cortical Carcinoma |
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| Disseminated Chorioretinitis |
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| Systolic Heart Failure |
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| Type 2 Diabetes Mellitus |
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| Endocrine Organ Benign Neoplasm |
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| Chronic Kidney Disease |
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| Adult Malignant Schwannoma |
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| Lipoprotein Quantitative Trait Locus |
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| Diabetes Mellitus |
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| Schizophrenia |
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| Migraine With Or Without Aura 1 |
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| Stroke, Ischemic |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | ADM | VGNC | VGNC:25681 |
| Mus musculus | ADM | MGD | MGI:108058 |
| Rattus norvegicus | ADM | RGD | RGD:2047 |
| Felis catus | ADM | VGNC | VGNC:105838 |
| Macaca mulatta | ADM | VGNC | VGNC:69699 |
| Canis familiaris | ADM | VGNC | VGNC:37660 |
| Others | ADM | NCBI |