Drd2 - dopamine receptor D2 Gene

Also Known as D2R; Drd-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13489

About Drd2

Chromosome 9: 49,251,927-49,319,477 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 207 orthologues, 24 paralogues and is associated with 128 phenotypes. Biased expression in CNS E18 (RPKM 3.9), cortex adult (RPKM 2.9) and 8 other tissues.

Summary

Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in hyaloid vascular plexus regression; negative regulation of innate immune response; and regulation of neurotransmitter transport. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of ion transport. Located in several cellular components, including GABA-ergic synapse; dendrite; and dopaminergic synapse. Is integral component of postsynaptic membrane. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (Dopamine Receptor D2). [provided by Alliance of Genome Resources, Apr 2022]

Drd2 Products (2)

mRNA	Protein	Name
NM_010077.3	NP_034207.2	D(2) dopamine receptor isoform 1
NM_001410193.1	NP_001397122.1	D(2) dopamine receptor isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	14712229	MGI
enables dopamine binding	IDA IDA: Inferred from direct assay	15716360	MGI
enables dopamine neurotransmitter receptor activity	IDA IDA: Inferred from direct assay	18671743	MGI
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IDA IDA: Inferred from direct assay	1980140	MGI
enables dopamine neurotransmitter receptor activity, coupled via Gi/Go	IMP IMP: Inferred from mutant phenotype	9140068	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25865831	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of G protein-coupled dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12097513	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	14712229	MGI
acts upstream of or within adenohypophysis development	IMP IMP: Inferred from mutant phenotype	9140068	MGI
acts upstream of or within adenylate cyclase-inhibiting dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	12665504	MGI
acts upstream of or within adenylate cyclase-inhibiting dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12223546	MGI
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	11303741	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	7566118	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	12084937	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	11438590	MGI
acts upstream of or within behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	17426149	MGI
acts upstream of or within behavioral response to ethanol	IMP IMP: Inferred from mutant phenotype	11105945	MGI
acts upstream of or within branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	11438590	MGI
acts upstream of cell migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	9247268	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9140068	MGI
acts upstream of or within cerebral cortex GABAergic interneuron migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16606840	MGI
acts upstream of or within dopamine metabolic process	IMP IMP: Inferred from mutant phenotype	7925842	MGI
acts upstream of dopamine uptake involved in synaptic transmission	IMP IMP: Inferred from mutant phenotype	9886065	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	9247268	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9247268	MGI
acts upstream of or within feeding behavior	IGI IGI: Inferred from genetic interaction	15272078	MGI
acts upstream of or within grooming behavior	IMP IMP: Inferred from mutant phenotype	10698004	MGI
involved in hyaloid vascular plexus regression	IMP IMP: Inferred from mutant phenotype	30936473	MGI
acts upstream of or within locomotory behavior	IGI IGI: Inferred from genetic interaction	9354330	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	9547254	MGI
acts upstream of or within modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	10974427	MGI
acts upstream of or within negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	11566895	MGI
acts upstream of or within negative regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	9247268	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	9140068	MGI
acts upstream of or within negative regulation of dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12097513	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	9247268	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	9247268	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	23242137	MGI
acts upstream of or within negative regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17251429	MGI
acts upstream of or within negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11160501	MGI
acts upstream of or within nervous system process involved in regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	11566895	MGI
acts upstream of neuroblast proliferation	IDA IDA: Inferred from direct assay	17426594	MGI
acts upstream of neuron migration	IMP IMP: Inferred from mutant phenotype	17409246	MGI
acts upstream of or within neuron-neuron synaptic transmission	IMP IMP: Inferred from mutant phenotype	12084937	MGI
acts upstream of or within peristalsis	IGI IGI: Inferred from genetic interaction	15272078	MGI
acts upstream of or within peristalsis	IMP IMP: Inferred from mutant phenotype	16525059	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	17251429	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IDA IDA: Inferred from direct assay	15016423	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17194762	MGI
acts upstream of or within pigmentation	IMP IMP: Inferred from mutant phenotype	9140068	MGI
acts upstream of or within positive regulation of dopamine uptake involved in synaptic transmission	IMP IMP: Inferred from mutant phenotype	9886065	MGI
acts upstream of or within positive regulation of growth hormone secretion	IMP IMP: Inferred from mutant phenotype	11897683	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	11897683	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	17426594	MGI
acts upstream of or within positive regulation of renal sodium excretion	IMP IMP: Inferred from mutant phenotype	11566895	MGI
acts upstream of or within positive regulation of urine volume	IMP IMP: Inferred from mutant phenotype	11566895	MGI
NOT acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	17324452	MGI
acts upstream of or within prepulse inhibition	IMP IMP: Inferred from mutant phenotype	10341260	MGI
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	12223553	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12223553	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	12223553	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	10828532	MGI
acts upstream of or within regulation of dopamine uptake involved in synaptic transmission	IMP IMP: Inferred from mutant phenotype	12223553	MGI
acts upstream of or within regulation of heart rate	IMP IMP: Inferred from mutant phenotype	11566895	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	9169514	MGI
involved in regulation of neurotransmitter uptake	EXP EXP: Inferred from Experiment	12223553	MGI
involved in regulation of neurotransmitter uptake	IDA IDA: Inferred from direct assay	12223553	MGI
involved in regulation of neurotransmitter uptake	IMP IMP: Inferred from mutant phenotype	12223553	MGI
acts upstream of or within regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	11566895	MGI
acts upstream of or within regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	11566895	MGI
acts upstream of or within regulation of synaptic transmission, GABAergic	IGI IGI: Inferred from genetic interaction	10934242	MGI
acts upstream of or within regulation of synaptic transmission, GABAergic	IMP IMP: Inferred from mutant phenotype	15080900	MGI
acts upstream of or within response to amphetamine	IGI IGI: Inferred from genetic interaction	12097513	MGI
acts upstream of or within response to amphetamine	IMP IMP: Inferred from mutant phenotype	18486343	MGI
acts upstream of or within response to cocaine	IDA IDA: Inferred from direct assay	18671743	MGI
acts upstream of or within response to cocaine	IMP IMP: Inferred from mutant phenotype	11923462	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	16715079	MGI
acts upstream of or within response to morphine	IMP IMP: Inferred from mutant phenotype	9252189	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	7549459	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	16136297	MGI
acts upstream of or within sensory perception of smell	IMP IMP: Inferred from mutant phenotype	16765459	MGI
NOT acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	17324452	MGI
acts upstream of or within startle response	IMP IMP: Inferred from mutant phenotype	17712281	MGI
acts upstream of or within temperature homeostasis	IMP IMP: Inferred from mutant phenotype	10471093	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	12097513	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	27035941	MGI
located in axon	IDA IDA: Inferred from direct assay	10051229	MGI
is active in cilium	IDA IDA: Inferred from direct assay	26053317	MGI
located in dendrite	IDA IDA: Inferred from direct assay	10051229	MGI
is active in dopaminergic synapse	EXP EXP: Inferred from Experiment	12223553	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	12223553	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	12223553	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27035941	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	27035941	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	27035941	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Drd2 Protein Structure

7tmA_D2_dopamine_R

0
100
200
300
400
444 a.a.

Protein Preferred Names	Protein Names
D(2) dopamine receptor	dopamine receptor 2

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13736A	Quinagolide hydrochloride		99.55%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14423	Velneperit	Antagonist	98.25%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N5074	Terrestrosin D		99.30%	Unkown
HY-120920	UNC9995	Agonist	99.93%	Unkown
HY-W040146	Propionylpromazine hydrochloride	Antagonist	99.71%	Unkown
HY-RS03997	DRD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-111480	Propionylpromazine	Antagonist	99.09%	Unkown
HY-W040146S	Propionylpromazine-d6 hydrochloride	Antagonist	99.78%	Unkown
HY-RS03998	Drd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03999	Drd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd2	NCBI	NCBI:1813