Drd2 - dopamine receptor D2 Gene

Mus musculus

Also known as D2R; Drd-2

Gene ID: 13489 | Gene type: protein coding

About Drd2

Chromosome 9: 49,251,927-49,319,477 forward strand.GRCm39:CM001002.3

This gene has 1 transcript (splice variant), 207 orthologues, 24 paralogues and is associated with 128 phenotypes. Biased expression in CNS E18 (RPKM 3.9), cortex adult (RPKM 2.9) and 8 other tissues.

Summary

Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in hyaloid vascular plexus regression; negative regulation of innate immune response; and regulation of neurotransmitter transport. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of ion transport. Located in several cellular components, including GABA-ergic synapse; dendrite; and dopaminergic synapse. Is integral component of postsynaptic membrane. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (Dopamine Receptor D2). [provided by Alliance of Genome Resources, Apr 2022]

Drd2 Products(2)

mRNA	Protein	Name
NM_010077.3	NP_034207.2	D(2) dopamine receptor isoform 1
NM_001410193.1	NP_001397122.1	D(2) dopamine receptor isoform 2

Drd2 Protein Structure

7tmA_D2_dopamine_R

0
100
200
300
400
444 a.a.

Protein Preferred Names

Protein Names

D(2) dopamine receptor

dopamine receptor 2

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13736A	Quinagolide hydrochloride		/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-135147	ONC206	Antagonist	99.90%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120920	UNC9995	Agonist	99.38%	Unkown
HY-W040146	Propionylpromazine hydrochloride	Antagonist	95.01%	Unkown
HY-W040146S	Propionylpromazine-d6 hydrochloride	Antagonist	99.78%	Unkown
HY-125125	Danshenxinkun D		/	Unkown
HY-RS03997	DRD2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS03998	Drd2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03999	Drd2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drd2	NCBI	NCBI:1813

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