S1pr4 - sphingosine-1-phosphate receptor 4 Gene

Also Known as Edg6; Lpc1; S1p4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13611

About S1pr4

Chromosome 10: 81,333,581-81,335,966 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 4 phenotypes.

Summary

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially Other aspects of immune activation. [provided by RefSeq, Feb 2010]

S1pr4 Products (1)

mRNA Protein Name
NM_010102.2 NP_034232.1 sphingosine 1-phosphate receptor 4

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11443127 MGI
Cellular Component GO Annotation Evidence References Source
is active in presynapse IDA
IDA: Inferred from direct assay
35781853 MGI
is active in presynapse IEP
IEP: Inferred from expression pattern
35781853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr4 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (50 - 319)

7tm_GPCRs

7tm_GPCRs: cd14964 (51 - 75)

7tm_GPCRs

7tm_GPCRs: cd14964 (84 - 105)

7tm_GPCRs

7tm_GPCRs: cd14964 (121 - 143)

7tm_GPCRs

7tm_GPCRs: cd14964 (165 - 181)

7tm_GPCRs

7tm_GPCRs: cd14964 (202 - 225)

7tm_GPCRs

7tm_GPCRs: cd14964 (251 - 273)

7tm_GPCRs

7tm_GPCRs: cd14964 (287 - 312)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 4

  • S1P receptor Edg-6

  • S1p receptor 4

  • endothelial differentiation G-protein-coupled receptor 6

  • lysophospholipid receptor C1

  • sphingosine 1-phosphate receptor Edg-6

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12355A Siponimod hemifumarate Agonist 99.85% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136462 CYM50358 Antagonist 98.33% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-116146 CYM50179 Agonist 96.06% Unkown
HY-W040167 VPC 23153 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr4 NCBI NCBI:8698