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Flt1 - FMS-like tyrosine kinase 1 Gene

Also Known as Flt-1; sFlt1; VEGFR1; VEGFR-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14254

About Flt1

Chromosome 5: 147,498,414-147,662,821 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 199 orthologues, 53 paralogues and is associated with 24 phenotypes. Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues.

Summary

Enables identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Flt1 Products (2)

mRNA	Protein	Name
NM_001363135.1	NP_001350064.1	vascular endothelial growth factor receptor 1 isoform 2 precursor
NM_010228.4	NP_034358.2	vascular endothelial growth factor receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11591653	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25893857	MGI
enables vascular endothelial growth factor receptor activity	IDA IDA: Inferred from direct assay	8356051	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	14982871	MGI
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	7596436	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	14982871	MGI
acts upstream of or within cell migration	IGI IGI: Inferred from genetic interaction	15601856	MGI
involved in cell migration	IMP IMP: Inferred from mutant phenotype	9689083	MGI
involved in embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	7596436	MGI
involved in hyaloid vascular plexus regression	IMP IMP: Inferred from mutant phenotype	30936473	MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	18772315	MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis	IGI IGI: Inferred from genetic interaction	22426483	MGI
acts upstream of or within response to hypoxia	IMP IMP: Inferred from mutant phenotype	18772315	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19758562	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9689083	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	25184477	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22886301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Flt1 Protein Structure

Ig_3

IGc2

I-set

PKc_like

0
300
600
900
1200
1333 a.a.

Protein Preferred Names	Protein Names
vascular endothelial growth factor receptor 1	embryonic receptor kinase 2 tyrosine-protein kinase receptor FLT vascular permeability factor receptor

Recombinant Flt1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73553	VEGFR-1 Protein, Mouse (HEK293, His)	P35969/NP_034358.2 (Y23-E759)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50751	Linifanib		99.39%	Phase 3
HY-10205	Cediranib		99.87%	Phase 3
HY-10517	Orantinib		99.29%	Phase 3
HY-100315	XL 999	Inhibitor	99.01%	Phase 2
HY-50703	MK-2461	Inhibitor	99.28%	Phase 2
HY-10204	OSI-930		98.33%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991430	RO5323441	Inhibitor	95.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15813	FIIN-1	Inhibitor	99.04%	Unkown
HY-P10831	GNQWFI	Antagonist	99.45%	Unkown
HY-108551	MG-262		95.0%	Unkown
HY-13049	Cediranib maleate		99.68%	Yes
HY-145293	TNIK-IN-3	Inhibitor	99.79%	Unkown
HY-P5438	Srctide	Substrate	99.71%	Unkown
HY-101219	VEGFR-IN-1	Inhibitor	99.07%	Unkown
HY-50751G	Linifanib (GMP)	Inhibitor	/	Unkown
HY-110272	Vatalanib succinate	Inhibitor	/	Unkown
HY-123586	L-783277	Inhibitor	/	Unkown
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	Unkown
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	Unkown
HY-181754	TPKI-39	Inhibitor	/	Unkown
HY-182354	VEGFR2-IN-84	Inhibitor	/	Unkown
HY-18692	Multi-kinase-IN-12	Inhibitor	/	Unkown
HY-NP223	PLGF-2 Protein, human		/	Unkown
HY-RS04987	FLT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04988	Flt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04989	Flt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174684	Human FLT1 mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99364	Icrucumab		99.9%	Unkown
HY-P990541	Anti-VEGFR1/FLT1 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Flt1	NCBI	NCBI:2321