CSRP2 - cysteine and glycine rich protein 2 Gene

Also Known as CRP2; LMO5; SmLIM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1466

About CSRP2

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,858,709-76,879,019 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 37.2), placenta (RPKM 35.3) and 23 other tissues.

Summary

CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CSRP2 Products (9)

mRNA Protein Name
NM_001300965.2 NP_001287894.1 cysteine and glycine-rich protein 2 isoform b
NM_001321.3 NP_001312.1 cysteine and glycine-rich protein 2 isoform b
NM_001413535.1 NP_001400464.1 cysteine and glycine-rich protein 2 isoform b
NM_001413537.1 NP_001400466.1 cysteine and glycine-rich protein 2 isoform b
NM_001413538.1 NP_001400467.1 cysteine and glycine-rich protein 2 isoform b
NM_001413539.1 NP_001400468.1 cysteine and glycine-rich protein 2 isoform a
NM_001413540.1 NP_001400469.1 cysteine and glycine-rich protein 2 isoform c
NM_001413541.1 NP_001400470.1 cysteine and glycine-rich protein 2 isoform d
NM_001413542.1 NP_001400471.1 cysteine and glycine-rich protein 2 isoform e

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSRP2 Protein Structure

LIM

LIM: LIM domain (10 - 65)

LIM

LIM: LIM domain (119 - 175)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

cysteine and glycine-rich protein 2

  • LIM domain only 5, smooth muscle

CSRP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSRP2 Q16527 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra
CSRP2 Q16527 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra
CSRP2 Q16527 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra
CSRP2 Q16527 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
CSRP2 Q16527 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
CSRP2 Q16527 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
CSRP2 Q16527 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
CSRP2 Q16527 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
CSRP2 Q16527 ARC Homo sapiens Q7LC44
Validated Y2H
32296183
Intra
CSRP2 Q16527 ARC Homo sapiens Q7LC44
Y2H Prey Pooling
32296183
Intra
CSRP2 Q16527 ARC Homo sapiens Q7LC44
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 8q21.11 Deletion Syndrome

  • 8q21.11 Microdeletion Syndrome

  • Del(8)(Q21.11)

  • Deletion 8q21.11

  • Monosomy 8q21.11
Fanconi Anemia, Complementation Group C

  • Fanconi Anemia Complementation Group C

  • FANCC

  • Facc

  • Fac

  • Fa3

  • Fanconi Pancytopenia Type 3

  • Fanconi Pancytopenia, Type 3

  • Faces Syndrome

  • Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies

  • Friedman-Goodman Syndrome

  • Abnormality Of The Face
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta CSRP2 VGNC VGNC:71528
Rattus norvegicus CSRP2 RGD RGD:61950
Bos taurus CSRP2 VGNC VGNC:27774
Felis catus CSRP2 VGNC VGNC:83862
Mus musculus CSRP2 MGD MGI:1202907
Others CSRP2 NCBI