CD300LF - CD300 molecule like family member f Gene

Also Known as CLM1; NKIR; CLM-1; IREM1; LMIR3; CD300f; IREM-1; IgSF13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 146722

About CD300LF

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,694,317-74,712,923 (from NCBI)

This gene has 10 transcripts (splice variants), 288 orthologues and 13 paralogues. Biased expression in spleen (RPKM 9.3), bone marrow (RPKM 8.2) and 10 other tissues.

Summary

This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

CD300LF Products (7)

mRNA Protein Name
NM_001289082.2 NP_001276011.1 CMRF35-like molecule 1 isoform 2
NM_001289083.2 NP_001276012.1 CMRF35-like molecule 1 isoform 3 precursor
NM_001289084.2 NP_001276013.1 CMRF35-like molecule 1 isoform 4
NM_001289085.2 NP_001276014.1 CMRF35-like molecule 1 isoform 5
NM_001289086.2 NP_001276015.1 CMRF35-like molecule 1 isoform 6
NM_001289087.2 NP_001276016.1 CMRF35-like molecule 1 isoform 7 precursor
NM_139018.5 NP_620587.2 CMRF35-like molecule 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ceramide binding IDA
IDA: Inferred from direct assay
24035150 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20959446 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20959446 GOA
Biological Process GO Annotation Evidence References Source
involved in TRIF-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22043923 GOA
involved in negative regulation of MyD88-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22043923 GOA
involved in negative regulation of mast cell activation IDA
IDA: Inferred from direct assay
24035150 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD300LF Protein Structure

V-set

V-set: Immunoglobulin V-set domain (21 - 116)

SIT

SIT: SHP2-interacting transmembrane adaptor protein, SIT (157 - 260)

  • 0
  • 100
  • 200
  • 290 a.a.
Protein Preferred Names Protein Names

CMRF35-like molecule 1

  • CD300 antigen-like family member F

CD300LF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD300LF Q8TDQ1 CD300LB Homo sapiens A8K4G0
Anti Tag CoIP
20959446
Intra
CD300LF Q8TDQ1 CD300LF Homo sapiens Q8TDQ1
Anti Tag CoIP
22291008
Intra
CD300LF Q8TDQ1 CD300LF Homo sapiens Q8TDQ1
Anti Tag CoIP
29051512
Intra
CD300LF Q8TDQ1 PTPN6 Homo sapiens P29350
CoIP
15549731
Intra
CD300LF Q8TDQ1 CD300LF Homo sapiens Q8TDQ1
Anti Tag CoIP
20959446
Intra
CD300LF Q8TDQ1 CD300LD Homo sapiens Q6UXZ3
Anti Tag CoIP
22291008
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD300LF Proteins

Cat. No. Product Name Accession Purity
HY-P71595 CD300LF Protein, Human (His) Q8TDQ1-1 (T20-S156) ≥ 90%, as determined by reducing SDS-PAGE.

CD300LF Antibodies

Cat. No. Product Name Application Reactivity
HY-P84684 CD300F Antibody (YA4381) IHC-P, FC, ELISA Human
HY-P84684A CD300F Antibody (YA4381)(PBS only) IHC-P, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02231 CD300LF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19087 Cd300lf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25577 Cd300lf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CD300LF VGNC VGNC:70910
Mus musculus CD300LF MGD MGI:2442359
Rattus norvegicus CD300LF RGD RGD:1309733
Felis catus CD300LF VGNC VGNC:60611
Others CD300LF NCBI