Haspin - histone H3 associated protein kinase Gene

Also Known as Gsg2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14841

About Haspin

Chromosome 11: 73,026,311-73,029,120 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 174 orthologues, 4 paralogues and is associated with 1 phenotype.

Summary

Enables ATP binding activity; DNA binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Haspin Products (1)

mRNA Protein Name
NM_010353.2 NP_034483.1 serine/threonine-protein kinase haspin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
10358056 MGI
enables DNA binding IDA
IDA: Inferred from direct assay
10358056 MGI
enables histone kinase activity IMP
IMP: Inferred from mutant phenotype
25645018 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10358056 MGI
Biological Process GO Annotation Evidence References Source
involved in chromosome organization involved in meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
25645018 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
25645018 MGI
involved in homologous chromosome segregation IMP
IMP: Inferred from mutant phenotype
25645018 MGI
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
10358056 MGI
involved in meiotic cell cycle process IMP
IMP: Inferred from mutant phenotype
25645018 MGI
involved in meiotic metaphase I IMP
IMP: Inferred from mutant phenotype
25645018 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
10358056 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10358056 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
25645018 MGI
Cellular Component GO Annotation Evidence References Source
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
10358056 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10358056 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Haspin Protein Structure

PKc_like

PKc_like: cl21453 (390 - 746)

  • 0
  • 200
  • 400
  • 600
  • 754 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase haspin

  • germ cell associated 2, haspin

  • germ cell-specific gene 2 protein

  • haploid germ cell-specific nuclear protein kinase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-30012 5-Bromo-7-azaindole 99.96% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15424 5-Iodotubercidin Inhibitor 99.95% Unkown
HY-15217 CHR-6494 Inhibitor 99.28% Unkown
HY-146636 Haspin-IN-3 Inhibitor 98.04% Unkown
HY-13455 LDN-192960 Inhibitor 99.58% Unkown
HY-13455A LDN-192960 hydrochloride Inhibitor 99.83% Unkown
HY-100368 MELK-8a 98.32% Unkown
HY-110320 LDN-209929 dihydrochloride Inhibitor 98.33% Unkown
HY-170546 MU1920 Inhibitor 98.22% Unkown
HY-110350 CHR-6494 TFA Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-155341 HSK205 Inhibitor 98.01% Unkown
HY-163858 Haspin-IN-4 Inhibitor / Unkown
HY-179486 Anticancer agent 285 Inhibitor / Unkown
HY-RS06009 HASPIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06010 Haspin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06011 Haspin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112366 FLT3-IN-38 Inhibitor / Unkown
HY-135002 LDN-209929 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Haspin NCBI NCBI:83903