HASPIN - histone H3 associated protein kinase Gene

Also Known as GSG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83903

About HASPIN

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,723,903-3,726,699 (from NCBI)

This gene has 1 transcript (splice variant), 174 orthologues and 4 paralogues.

Summary

Enables ATP binding activity and histone kinase activity (H3-T3 specific). Involved in histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore; intracellular signal transduction; and mitotic sister chromatid cohesion. Located in centrosome; nucleoplasm; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

HASPIN Products (1)

mRNA Protein Name
NM_031965.2 NP_114171.2 serine/threonine-protein kinase haspin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11228240 GOA
enables histone H3T3 kinase activity IMP
IMP: Inferred from mutant phenotype
15681610 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19918049 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
11228240 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
11228240 GOA
involved in mitotic sister chromatid cohesion IMP
IMP: Inferred from mutant phenotype
20705812 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
23071153 GOA
involved in protein localization to chromosome, centromeric region IMP
IMP: Inferred from mutant phenotype
20705812 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
11228240 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
11228240 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11228240 GOA
located in spindle IDA
IDA: Inferred from direct assay
15681610 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HASPIN Protein Structure

Pkinase

Pkinase: Protein kinase domain (486 - 687)

Haspin_kinase

Haspin_kinase: Haspin like kinase domain (708 - 797)

  • 0
  • 200
  • 400
  • 600
  • 798 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase haspin

  • H-haspin

  • germ cell associated 2, haspin

  • germ cell-specific gene 2 protein

  • haploid germ cell-specific nuclear protein kinase

HASPIN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HASPIN Q8TF76 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra
HASPIN Q8TF76 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
HASPIN Q8TF76 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
HASPIN Q8TF76 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
HASPIN Q8TF76 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
HASPIN Q8TF76 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15424 5-Iodotubercidin Inhibitor 99.95% Unkown
HY-15217 CHR-6494 Inhibitor 99.28% Unkown
HY-146636 Haspin-IN-3 Inhibitor 98.04% Unkown
HY-13455 LDN-192960 Inhibitor 99.58% Unkown
HY-13455A LDN-192960 hydrochloride Inhibitor 99.83% Unkown
HY-100368 MELK-8a 98.32% Unkown
HY-110320 LDN-209929 dihydrochloride Inhibitor 98.33% Unkown
HY-170546 MU1920 Inhibitor 98.22% Unkown
HY-110350 CHR-6494 TFA Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-155341 HSK205 Inhibitor 98.01% Unkown
HY-163858 Haspin-IN-4 Inhibitor / Unkown
HY-179486 Anticancer agent 285 Inhibitor / Unkown
HY-RS06009 HASPIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06010 Haspin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06011 Haspin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112366 FLT3-IN-38 Inhibitor / Unkown
HY-135002 LDN-209929 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus HASPIN MGD MGI:1194498
Bos taurus HASPIN VGNC VGNC:55834
Macaca mulatta HASPIN VGNC VGNC:104614
Canis familiaris HASPIN VGNC VGNC:49092
Felis catus HASPIN VGNC VGNC:62754
Rattus norvegicus HASPIN RGD RGD:1596276
Others HASPIN NCBI