Hcn2 - hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Gene

Also Known as HAC1; trls; BCNG2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15166

Summary

Predicted to enable several functions, including PDZ domain binding activity; cation channel activity; and identical protein binding activity. Acts upstream of or within regulation of membrane potential. Predicted to be located in several cellular components, including axon; dendrite; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be part of HCN Channel complex. Is expressed in heart; heart ventricle; spinal cord; and ventral grey horn. Human ortholog(s) of this gene implicated in familial febrile seizures 2. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and Sodium Channel 2). [provided by Alliance of Genome Resources, Apr 2022]

Hcn2 Products (1)

mRNA Protein Name
NM_008226.2 NP_032252.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15564593 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
15564593 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
15564593 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
30886335 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

  • BCNG-2

  • HAC-1

  • brain cyclic nucleotide-gated channel 2

  • hyperpolarization-activated cation channel 1

Hcn2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Hcn2 O88703 SRC Gallus gallus P00523
Y2H
16079136
Cross
Hcn2 O88703 SRC Gallus gallus P00523
Pull Down
16079136
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160505 RO-275 Inhibitor 99.95% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-186056 HCN2-IN-3 Inhibitor / Unkown
HY-186057 HCN2-IN-5 Inhibitor / Unkown
HY-186058 HCN2-IN-6 Inhibitor / Unkown
HY-186059 HCN2 modulator-4 Inhibitor / Unkown
HY-186059A HCN2 modulator-5 Inhibitor / Unkown
HY-186060 HCN2 modulator-6 Inhibitor / Unkown
HY-186061 HCN2-IN-4 Inhibitor / Unkown
HY-186061A HCN2 modulator-8 Inhibitor / Unkown
HY-186062 HCN-IN-1 / Unkown
HY-186065 HCN2-IN-1 Inhibitor / Unkown
HY-186066 HCN2-IN-2 Inhibitor / Unkown
HY-RS06047 HCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18617 Hcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25103 Hcn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcn2 NCBI NCBI:610