H2ax - H2A.X variant histone Gene

Also Known as H2A.X; H2afx; Hist5-2ax; gammaH2ax

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15270

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. [provided by RefSeq, Nov 2015]

H2ax Products (1)

mRNA Protein Name
NM_010436.2 NP_034566.1 histone H2AX

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables damaged DNA binding IDA
IDA: Inferred from direct assay
11934988 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17304220 MGI
Biological Process GO Annotation Evidence References Source
NOT acts upstream of or within DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
11934988 MGI
acts upstream of or within DNA repair IDA
IDA: Inferred from direct assay
15364958 MGI
acts upstream of or within DNA repair IMP
IMP: Inferred from mutant phenotype
11934988 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
11934988 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
11934988 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
18070917 MGI
located in chromatin IDA
IDA: Inferred from direct assay
11934988 MGI
located in chromosome IDA
IDA: Inferred from direct assay
23039116 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
20551173 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
14611631 MGI
located in nucleus IDA
IDA: Inferred from direct assay
20360685 MGI
located in replication fork IDA
IDA: Inferred from direct assay
15364958 MGI
located in site of double-strand break IDA
IDA: Inferred from direct assay
22699483 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H2AX

  • H2A histone family, member X

  • H2a/x

  • histone 5 protein 2ax

  • histone H2A.x

H2ax Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H2ax P27661 Fancd2 Mus musculus Q80V62
Anti Bait CoIP
17304220
Intra
H2ax P27661 Aifm1 Mus musculus Q9Z0X1
Anti Tag CoIP
20360685
Intra
H2ax P27661 Aifm1 Mus musculus Q9Z0X1
Confocal
20360685
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113041 Prostaglandin A2 99.9% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12037 Rigosertib sodium 99.57% Phase 3
HY-18174H Prexasertib lactate / Phase 2

Pre-clinical Phase

Bioactive Molecules (39)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18174 Prexasertib 99.64% Unkown
HY-117693 (E/Z)-Mirin Inhibitor 99.22% Unkown
HY-123834 FEN1-IN-1 99.85% Unkown
HY-12037A Rigosertib 99.01% Unkown
HY-101089 RHPS4 99.88% Unkown
HY-122181 OTS186935 Inhibitor 99.69% Unkown
HY-18174A Prexasertib dihydrochloride 99.73% Unkown
HY-158975 VRK1/CK1-IN-1 Inhibitor 98.69% Unkown
HY-122181B OTS186935 hydrochloride Inhibitor 99.58% Unkown
HY-W1126504 ETN029 Ligand 99.91% Unkown
HY-18174E Prexasertib dimesylate 98.90% Unkown
HY-N0316 Mollugin 99.79% Unkown
HY-103241 Ro 90-7501 98.50% Unkown
HY-163944 LL-K12-18 98.42% Unkown
HY-122182 OTS193320 99.11% Unkown
HY-N2445 Flavokawain C 99.79% Unkown
HY-181557 SY-589 98.50% Unkown
HY-18174B Prexasertib Mesylate Hydrate / Unkown
HY-RS05957 H2AX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-18174C Prexasertib mesylate / Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-117688 WJ35435 / Unkown
HY-121777 SFOM-0046 Inhibitor / Unkown
HY-122860 SKLB-C05 / Unkown
HY-132972 TrxR-IN-2 / Unkown
HY-145288 Antitumor agent-36 / Unkown
HY-145289 Antitumor agent-37 / Unkown
HY-162985 JHD205 Inhibitor / Unkown
HY-167237 Calactin / Unkown
HY-168877 FMP Activator / Unkown
HY-174989 ATM-IN-2 / Unkown
HY-175700 YCJ-02 / Unkown
HY-181018 Topo I/DDX5-IN-1 / Unkown
HY-181678 DNA-PK/HDAC6-IN-1 / Unkown
HY-183330 Topo I/II-IN-3 / Unkown
HY-184416 GDD-261 / Unkown
HY-W414334 ICR-191 dihydrochloride Activator ≥95.0% Unkown
HY-RS16644 H2ax Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23078 H2ax Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens H2ax NCBI NCBI:3014