Mat2a - methionine adenosyltransferase 2A Gene

Also Known as Sams2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171347

Summary

Enables ATP binding activity; amino acid binding activity; and methionine adenosyltransferase activity. Involved in several processes, including S-adenosylmethionine biosynthetic process; circadian rhythm; and response to cAMP. Located in cytosol. Orthologous to human MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Mat2a Products (1)

mRNA Protein Name
NM_134351.1 NP_599178.1 S-adenosylmethionine synthase isoform type-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
12029623 RGD
enables amino acid binding IDA
IDA: Inferred from direct assay
12029623 RGD
enables methionine adenosyltransferase activity IDA
IDA: Inferred from direct assay
10898761 RGD
Biological Process GO Annotation Evidence References Source
involved in S-adenosylmethionine biosynthetic process IDA
IDA: Inferred from direct assay
10898761 RGD
involved in circadian rhythm IDA
IDA: Inferred from direct assay
15504733 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
15504733 RGD
involved in response to hormone IDA
IDA: Inferred from direct assay
15504733 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
15504733 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
15504733 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-adenosylmethionine synthase isoform type-2

  • MAT 2

  • MAT-II

  • adoMet synthase 2

  • adoMet synthetase 2

  • methionine adenosyltransferase 2

  • methionine adenosyltransferase II, alpha

  • non-hepatic-type S-adenosylmethionine synthetase

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-138630 AG-270 99.97% Phase 1
HY-112569 MAT2A inhibitor 2 Inhibitor 99.10% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107778 PF-9366 99.94% Unkown
HY-136144 FIDAS-5 98.46% Unkown
HY-112130 AGI-24512 Inhibitor 99.46% Unkown
HY-145778 AGI-41998 Inhibitor 98.72% Unkown
HY-169257 SCR-7952 Inhibitor 99.34% Unkown
HY-162353 AZ'9567 99.19% Unkown
HY-145777 AGI-43192 Inhibitor 99.47% Unkown
HY-112131 MAT2A inhibitor 1 99.57% Unkown
HY-139139 MAT2A inhibitor 3 99.27% Unkown
HY-136145 FIDAS-3 Inhibitor 99.40% Unkown
HY-139536 MAT2A inhibitor 4 99.60% Unkown
HY-RS16583 Mat2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08167 MAT2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23017 Mat2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-142928 MAT2A-IN-1 Inhibitor / Unkown
HY-142929 MAT2A-IN-2 Inhibitor / Unkown
HY-142930 MAT2A-IN-3 Inhibitor / Unkown
HY-144179 MAT2A-IN-4 Inhibitor / Unkown
HY-144181 MAT2A-IN-5 Inhibitor / Unkown
HY-144184 MAT2A-IN-6 Inhibitor / Unkown
HY-144185 MAT2A-IN-7 Inhibitor / Unkown
HY-149915 MAT2A-IN-10 Inhibitor / Unkown
HY-155148 MAT2A-IN-11 Inhibitor / Unkown
HY-155149 MAT2A-IN-12 Inhibitor / Unkown
HY-159156 MAT2A inhibitor 6 / Unkown
HY-161298 MAT2A-IN-15 Inhibitor / Unkown
HY-162010 MAT2A-IN-13 Inhibitor / Unkown
HY-162135 MAT2A-IN-14 / Unkown
HY-163656 MAT2A inhibitor 5 Inhibitor 98.80% Unkown
HY-168445 MAT2A-IN-21 Inhibitor / Unkown
HY-170421 MAT2A-IN-16 Inhibitor / Unkown
HY-170500 MAT2A-IN-17 Inhibitor / Unkown
HY-170501 MAT2A-IN-18 Inhibitor / Unkown
HY-170502 MAT2A-IN-19 Inhibitor / Unkown
HY-170503 MAT2A-IN-20 Inhibitor / Unkown
HY-170905S MAT2A-IN-22 Inhibitor / Unkown
HY-170906S MAT2A-IN-23 Inhibitor / Unkown
HY-173281 MAT2A-IN-24 Inhibitor / Unkown
HY-179622 ZS34 / Unkown
HY-181772 MCULE-3064932370 Inhibitor / Unkown
HY-182400 AGI-25696 Inhibitor / Unkown
HY-183568 MAT2A-IN-26 Inhibitor / Unkown
HY-181285 MAT2A ligand 1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mat2a NCBI NCBI:4144