Pak1 - p21 (RAC1) activated kinase 1 Gene

Also Known as Paka; PAK-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18479

About Pak1

Chromosome 7: 97,437,748-97,561,588 forward strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 217 orthologues, 35 paralogues and is associated with 14 phenotypes. Biased expression in cortex adult (RPKM 87.8), cerebellum adult (RPKM 86.8) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including glutamatergic synapse; growth cone; and postsynaptic density. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pak1 Products (6)

mRNA Protein Name
NM_001403479.1 NP_001390408.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_011035.3 NP_035165.2 serine/threonine-protein kinase PAK 1 isoform 1
NM_001357365.2 NP_001344294.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001357362.2 NP_001344291.1 serine/threonine-protein kinase PAK 1 isoform 2
NM_001357364.2 NP_001344293.1 serine/threonine-protein kinase PAK 1 isoform 1
NM_001357363.2 NP_001344292.1 serine/threonine-protein kinase PAK 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10967094 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14580336 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
28408623 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within amygdala development IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23509247 MGI
acts upstream of or within dendrite development IDA
IDA: Inferred from direct assay
12213441 MGI
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
23509247 MGI
acts upstream of or within gamma-aminobutyric acid secretion, neurotransmission IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within glutamate secretion, neurotransmission IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: Inferred from genetic interaction
12165471 MGI
acts upstream of or within observational learning IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within receptor clustering IGI
IGI: Inferred from genetic interaction
12165471 MGI
acts upstream of or within regulation of MAPK cascade IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
25242307 MGI
acts upstream of or within regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
25242307 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
EXP: Inferred from Experiment
27296803 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
IDA: Inferred from direct assay
27296803 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
27296803 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
27296803 MGI
acts upstream of or within transmission of nerve impulse IGI
IGI: Inferred from genetic interaction
27583434 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
27296803 MGI
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
27296803 MGI
is active in GABA-ergic synapse IEP
IEP: Inferred from expression pattern
27296803 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
27296803 MGI
located in axon IDA
IDA: Inferred from direct assay
12950086 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12213441 MGI
located in dendrite IDA
IDA: Inferred from direct assay
22022532 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15182717 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
15182717 MGI
located in growth cone IDA
IDA: Inferred from direct assay
11604394 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12950086 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15182717 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
15182717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak1 Protein Structure

PBD

PBD: pfam00786 (73 - 131)

STKc_PAK1

STKc_PAK1: cd06654 (247 - 542)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 1

  • CDC42/RAC effector kinase PAK-A

  • P21 CDKN1A-activated kinase 1

  • activated protein kinase alpha

  • alpha-PAK

  • p21 protein (Cdc42/Rac)-activated kinase 1

  • p21-activated kinase 1

  • p65-PAK

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12005 Fingolimod hydrochloride Activator 99.94% Yes
HY-15027 5-Aminosalicylic Acid Inhibitor 99.97% Unkown
HY-11063 Fingolimod Activator 99.97% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-110085 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Inhibitor 98.49% Phase 4
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15663 IPA-3 Inhibitor 99.39% Unkown
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-19635 G-5555 Inhibitor 99.88% Unkown
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-120940 AZ13705339 Inhibitor 98.57% Unkown
HY-19635A G-5555 hydrochloride Inhibitor 98.26% Unkown
HY-131043 NVS-PAK1-C Inhibitor 99.2% Unkown
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% Unkown
HY-182357 PAK1-IN-3 Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-116917 G-9791 Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-159897 PAK4-IN-5 Inhibitor / Unkown
HY-146783 ZINC194100678 Inhibitor / Unkown
HY-184145 AKT1-IN-13 Inhibitor / Unkown
HY-119216 AZ13711265 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-131265 Mesalamine impurity P Inhibitor / Unkown
HY-176539 PAK1-IN-2 Inhibitor / Unkown
HY-164374 AK963/40708899 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak1 NCBI NCBI:5058