Pak3 - p21 (RAC1) activated kinase 3 Gene

Also Known as Stk4; PAK-3; Pak65beta; Pak65alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18481

About Pak3

Chromosome X: 142,301,587-142,580,792 forward strand.GRCm39:CM001013.3

This gene has 10 transcripts (splice variants), 213 orthologues, 35 paralogues and is associated with 7 phenotypes. Biased expression in CNS E18 (RPKM 8.), whole brain E14.5 (RPKM 6.4) and 8 other tissues.

Summary

Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis and dendritic spine morphogenesis. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; gonad; liver; lung; and retina. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pak3 Products (5)

mRNA Protein Name
NM_001195046.1 NP_001181975.1 serine/threonine-protein kinase PAK 3 isoform A
NM_001195049.1 NP_001181978.1 serine/threonine-protein kinase PAK 3 isoform D
NM_001195048.1 NP_001181977.1 serine/threonine-protein kinase PAK 3 isoform C
NM_001195047.1 NP_001181976.1 serine/threonine-protein kinase PAK 3 isoform B
NM_008778.3 NP_032804.2 serine/threonine-protein kinase PAK 3 isoform D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
7493928 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
23509247 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
10445846 MGI
Biological Process GO Annotation Evidence References Source
involved in axonogenesis IMP
IMP: Inferred from mutant phenotype
21115725 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
23509247 MGI
involved in dendrite development IMP
IMP: Inferred from mutant phenotype
21115725 MGI
acts upstream of or within dendritic spine development IGI
IGI: Inferred from genetic interaction
23509247 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25851601 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
25851601 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
25851601 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15182717 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
15182717 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25851601 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
15182717 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
15182717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak3 Protein Structure

PBD

PBD: pfam00786 (68 - 140)

STKc_PAK3

STKc_PAK3: cd06656 (262 - 558)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 559 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 3

  • CDC42/RAC effector kinase PAK-B

  • beta-PAK

  • p21 protein (Cdc42/Rac)-activated kinase 3

  • p21-activated kinase 3

Pak3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Pak3 Q61036 CDC42 Homo sapiens P60953
Filter Binding
7493928
Cross
Pak3 Q61036 CDC42 Homo sapiens P60953
Solid Phase Assay
23022564
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1
HY-13007B PF-3758309 dihydrochloride Inhibitor / Phase 1
HY-13007A PF-3758309 hydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-123739 LDN-0028574 Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-178812 PI3Kα-IN-27 Inhibitor / Unkown
HY-118606 LDN-0044878 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak3 NCBI NCBI:5063