Plk1 - polo like kinase 1 Gene

Also Known as Plk; STPK13

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18817

About Plk1

Chromosome 7: 121,758,662-121,769,096 forward strand.GRCm39:CM001000.3

This gene has 3 transcripts (splice variants), 186 orthologues, 4 paralogues and is associated with 16 phenotypes. Broad expression in liver E14.5 (RPKM 39.9), liver E14 (RPKM 38.7) and 17 other tissues.

Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during Mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in Cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for Cancer therapy. [provided by RefSeq, Sep 2015]

Plk1 Products (1)

mRNA Protein Name
NM_011121.4 NP_035251.3 serine/threonine-protein kinase PLK1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22405274 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
21637952 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
22405274 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
27979967 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within female meiosis chromosome segregation IMP
IMP: Inferred from mutant phenotype
25533956 MGI
acts upstream of or within homologous chromosome segregation IMP
IMP: Inferred from mutant phenotype
25533956 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
27979967 MGI
acts upstream of or within peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
27979967 MGI
acts upstream of or within protein localization to organelle IDA
IDA: Inferred from direct assay
27979967 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22854038 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21637952 MGI
acts upstream of or within regulation of protein binding IMP
IMP: Inferred from mutant phenotype
27979967 MGI
acts upstream of or within synaptonemal complex disassembly IMP
IMP: Inferred from mutant phenotype
22854038 MGI
Cellular Component GO Annotation Evidence References Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
27979967 MGI
located in centriole IDA
IDA: Inferred from direct assay
27979967 MGI
located in chromatin IDA
IDA: Inferred from direct assay
22854038 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
located in condensed chromosome, centromeric region IDA
IDA: Inferred from direct assay
22854038 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
25533956 MGI
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
26919979 MGI
located in synaptonemal complex IDA
IDA: Inferred from direct assay
22854038 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk1 Protein Structure

STKc_PLK1

STKc_PLK1: cd14187 (44 - 308)

POLO_box_1

POLO_box_1: cd13118 (406 - 493)

POLO_box_2

POLO_box_2: cd13117 (508 - 589)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK1

  • PLK-1

  • serine/threonine-protein kinase 13

Recombinant Plk1 Proteins

Cat. No. Product Name Accession Purity
HY-P73706 PLK1 Protein, Mouse (Active, sf9, His) Q07832 (M1-S603) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12137A Volasertib trihydrochloride Inhibitor 99.12% Yes

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-12137 Volasertib Inhibitor 99.97% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-15828 Onvansertib Inhibitor 99.86% Phase 2
HY-147298 Plogosertib Inhibitor 98.59% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-12045 HMN-214 Inhibitor 99.94% Phase 1

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50698 BI 2536 Inhibitor 99.95% Unkown
HY-12037A Rigosertib Inhibitor 99.01% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-11003 GW843682X Inhibitor 99.89% Unkown
HY-15161 Ro3280 Inhibitor 99.46% Unkown
HY-15155 MLN0905 Inhibitor 99.94% Unkown
HY-W286743 Nε-(Carboxymethyl)-L-lysine Activator 99.70% Unkown
HY-108597 TC-S 7005 Inhibitor 99.68% Unkown
HY-12134 Poloxin Inhibitor 98.05% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-150259 MDEG-541 Degrader 98.68% Unkown
HY-15158 SBE13 Hydrochloride Inhibitor 98.56% Unkown
HY-123467 Lasiokaurin Inhibitor 99.68% Unkown
HY-158031 PLK1/BRD4-IN-5 Inhibitor 98.80% Unkown
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% Unkown
HY-179560 PMV6-PEG4-BI2536 Inhibitor 98.47% Unkown
HY-110002 LFM-A13 Inhibitor 99.65% Unkown
HY-15159 Cyclapolin 9 Inhibitor 98.09% Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor 98.55% Unkown
HY-N8692 Dihydrobaicalein Inhibitor 99.94% Unkown
HY-173212 PLK1-IN-13 Inhibitor 98.02% Unkown
HY-149100 PLK1-IN-6 Inhibitor 99.60% Unkown
HY-15160B TAK-960 dihydrochloride Inhibitor 99.15% Unkown
HY-77195 Poloxime Inhibitor 95.0% Unkown
HY-180989 PROTAC PLK1 Degrader-2 Degrader 99.48% Unkown
HY-169579 PLK1-IN-11 Inhibitor 99.52% Unkown
HY-15158A SBE13 Inhibitor / Unkown
HY-W162436 MCC1019 Inhibitor / Unkown
HY-N13795 3,4,3'-Tri-O-methylflavellagic acid Inhibitor / Unkown
HY-181001 POI ligand-4 Degrader / Unkown
HY-148974 PLK1-IN-5 Inhibitor / Unkown
HY-208742 ZNL-02-096 Inhibitor / Unkown
HY-112395 BTO-1 Inhibitor / Unkown
HY-172880 PLK1-IN-15 Inhibitor / Unkown
HY-161521 PLK1-IN-10 Inhibitor / Unkown
HY-173233 PLK1-IN-14 Inhibitor / Unkown
HY-181769 Anticancer agent 306 Inhibitor / Unkown
HY-18651 (E/Z)-Rigosertib sodium / Unkown
HY-180990 POI ligand-3 Inhibitor / Unkown
HY-172364 PLK1-IN-12 Inhibitor / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-181000 PROTAC PLK1 Degrader-3 Degrader / Unkown
HY-50698A (S)-BI 2536 Inhibitor / Unkown
HY-111090 GSK461364 analogue 1 Inhibitor / Unkown
HY-181030 BDE30671203 Inhibitor / Unkown
HY-172677 IIP0943 Inhibitor / Unkown
HY-184863 PLK1-IN-17 Inhibitor / Unkown
HY-183427 KBJK557 Inhibitor / Unkown
HY-181051 PLK1-IN-16 Inhibitor / Unkown
HY-15160A TAK-960 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk1 NCBI NCBI:5347