Rdx - radixin Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19684

Summary

Enables protein domain specific binding activity. Involved in cellular response to thyroid hormone stimulus; establishment of protein localization; and positive regulation of G1/S transition of mitotic cell cycle. Acts upstream of or within apical protein localization and microvillus assembly. Located in several cellular components, including lamellipodium; microvillus; and ruffle. Colocalizes with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and sensory organ. Used to study Dubin-Johnson syndrome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]

Rdx Products (3)

mRNA Protein Name
NM_001104616.1 NP_001098086.1 radixin isoform a
NM_001104617.1 NP_001098087.1 radixin isoform b
NM_009041.3 NP_033067.2 radixin isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9472040 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
21047789 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apical protein localization IMP
IMP: Inferred from mutant phenotype
12068294 MGI
involved in cellular response to thyroid hormone stimulus IMP
IMP: Inferred from mutant phenotype
21047789 MGI
involved in establishment of protein localization IMP
IMP: Inferred from mutant phenotype
21047789 MGI
acts upstream of or within microvillus assembly IMP
IMP: Inferred from mutant phenotype
12068294 MGI
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21047789 MGI
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping IDA
IDA: Inferred from direct assay
25891999 MGI
involved in regulation of postsynaptic neurotransmitter receptor diffusion trapping IMP
IMP: Inferred from mutant phenotype
25891999 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
9890997 MGI
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
21047789 MGI
located in filopodium IDA
IDA: Inferred from direct assay
9563848 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
9563848 MGI
located in microvillus IDA
IDA: Inferred from direct assay
9472040 MGI
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
21047789 MGI
located in ruffle IDA
IDA: Inferred from direct assay
9563848 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
17021174 MGI
located in stereocilium base IDA
IDA: Inferred from direct assay
24285636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

radixin

  • ESP10

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15991 Tenapanor Inhibitor 99.65% Unkown
HY-15991A Tenapanor hydrochloride Inhibitor 99.55% Unkown

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13631J (1R,9R)-Exatecan mesylate 99.49% Unkown
HY-13631I (1S,9R)-Exatecan mesylate 99.11% Unkown
HY-P2800 Diaphorase, Recombinant microorganisms / Unkown
HY-RS11806 RDX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13631V (1R,9R)-Exatecan / Unkown
HY-RS18121 Rdx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24595 Rdx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rdx NCBI NCBI:5962