Smarca4 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Gene

Also Known as Brg1; BAF190A; SW1/SNF; HP1-BP72; SNF2beta; b2b692Clo; b2b508.1Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20586

Summary

Enables several functions, including ATP hydrolysis activity; DNA Polymerase binding activity; and nucleic acid binding activity. Involved in nervous system development; positive regulation of Wnt signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including animal organ development; blastocyst development; and circulatory system development. Located in euchromatin; heterochromatin; and perichromatin fibrils. Part of SWI/SNF complex; nBAF complex; and npBAF complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Breast Cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; hepatocellular carcinoma; lung non-small cell carcinoma; and rhabdoid Cancer. Orthologous to human SMARCA4 (SWI/SNF related, matrix associated, Actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Apr 2022]

Smarca4 Products (4)

mRNA Protein Name
NM_001174078.1 NP_001167549.1 transcription activator BRG1 isoform 1
NM_001174079.1 NP_001167550.1 transcription activator BRG1 isoform 3
NM_001357764.1 NP_001344693.1 transcription activator BRG1 isoform 4
NM_011417.3 NP_035547.2 transcription activator BRG1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables ATP hydrolysis activity IMP
IMP: Inferred from mutant phenotype
22513373 MGI
enables ATP-dependent chromatin remodeler activity IDA
IDA: Inferred from direct assay
34910916 MGI
enables DNA polymerase binding IPI
IPI: Inferred from physical interaction
19571879 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23319608 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20176728 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
10318760 MGI
enables lncRNA binding IPI
IPI: Inferred from physical interaction
25119045 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7923370 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
15767674 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within aortic smooth muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
19342595 MGI
acts upstream of or within blastocyst growth IMP
IMP: Inferred from mutant phenotype
11163203 MGI
acts upstream of or within blastocyst hatching IMP
IMP: Inferred from mutant phenotype
11163203 MGI
acts upstream of or within blood vessel development IMP
IMP: Inferred from mutant phenotype
23319608 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within definitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
16192310 MGI
acts upstream of or within embryonic organ morphogenesis IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within epidermis morphogenesis IMP
IMP: Inferred from mutant phenotype
16192310 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
18267097 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
16330018 MGI
acts upstream of or within negative effect gene expression IDA
IDA: Inferred from direct assay
25119045 MGI
acts upstream of or within glial cell fate determination IMP
IMP: Inferred from mutant phenotype
16330018 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
18267097 MGI
acts upstream of or within heart trabecula formation IGI
IGI: Inferred from genetic interaction
18267097 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
16330018 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
16192310 MGI
acts upstream of or within lens fiber cell development IMP
IMP: Inferred from mutant phenotype
21118511 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23319608 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
18267097 MGI
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
17640523 MGI
acts upstream of or within neurogenesis IDA
IDA: Inferred from direct assay
22513373 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
23319608 MGI
acts upstream of or within pharyngeal arch artery morphogenesis IMP
IMP: Inferred from mutant phenotype
23319608 MGI
acts upstream of or within positive regulation of DNA binding IGI
IGI: Inferred from genetic interaction
19342595 MGI
involved in positive regulation of Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19571879 MGI
acts upstream of or within positive regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
23319608 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23319608 MGI
involved in positive regulation of cold-induced thermogenesis IDA
IDA: Inferred from direct assay
34910916 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22162999 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19342595 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within primitive erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
16287714 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
23319608 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20176728 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19342595 MGI
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: Inferred from direct assay
34910916 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
18267097 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
16287714 MGI
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
12368262 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
10318760 MGI
located in male germ cell nucleus IDA
IDA: Inferred from direct assay
16787967 MGI
part of nBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
part of npBAF complex IDA
IDA: Inferred from direct assay
17640523 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
10318760 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
34910916 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9603422 MGI
located in perichromatin fibrils IDA
IDA: Inferred from direct assay
10318760 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription activator BRG1

  • ATP-dependent helicase SMARCA4

  • BRG1-associated factor 190A

  • SNF2-beta

  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

  • protein brahma homolog 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-163410 AU-24118 Degrader 99.10% Phase 2
HY-159607 PRT3789 Degrader 98.08% Phase 2
HY-13030 (+)-JQ-1 Ligand 99.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-145388 AU-15330 Degrader 99.89% Unkown
HY-128359 ACBI1 Degrader 99.34% Unkown
HY-168221 YD54 Degrader 98.74% Unkown
HY-173351 G-6599 Degrader 98.30% Unkown
HY-173333 PROTAC SMARCA2/4 degrader-38 Degrader 99.46% Unkown
HY-44012 SMARCA-BD ligand 1 for PROTAC Ligand 99.07% Unkown
HY-44012B SMARCA-BD ligand 1 for PROTAC hydrochloride Ligand 99.24% Unkown
HY-44012A SMARCA-BD ligand 1 for PROTAC dihydrochloride Ligand 98.08% Unkown
HY-46618 SMARCA2/4-ligand-8 Ligand 99.66% Unkown
HY-148381 A947 Degrader / Unkown
HY-185075 FHD-909 Inhibitor / Unkown
HY-159457 PROTAC SMARCA2/4 degrader-6 Degrader / Unkown
HY-162834 PROTAC SMARCA2/4 degrader-27 Degrader / Unkown
HY-163867 PROTAC SMARCA2/4 degrader-44 Degrader / Unkown
HY-169280 PXR Ligand 2 / Unkown
HY-170354 SMARCA2/4-ligand-4 Ligand / Unkown
HY-168252 BRM/BRG1 ligand 3 Ligand / Unkown
HY-170817 SMI-1074 Inhibitor / Unkown
HY-168248 BRM/BRG1 ligand 2 Ligand / Unkown
HY-159459 PROTAC SMARCA2/4 degrader-32 Degrader / Unkown
HY-159454 PROTAC SMARCA2/4 degrader-3 Degrader / Unkown
HY-163949 SMARCA2/4-IN-3 Inhibitor / Unkown
HY-153425 PROTAC SMARCA2/4 degrader-41 Degrader / Unkown
HY-162813 PROTAC SMARCA2/4 degrader-25 Degrader / Unkown
HY-162748 PROTAC SMARCA2/4 degrader-30 Degrader / Unkown
HY-162814 SMARCA2/4-ligand-3 Ligand / Unkown
HY-170347 PROTAC SMARCA2/4 degrader-36 Degrader / Unkown
HY-162815 PROTAC SMARCA2/4 degrader-26 Degrader / Unkown
HY-162745 PROTAC SMARCA2/4 degrader-42 Degrader / Unkown
HY-171774 PBRM1/SMARCA2,4-ligand-1 / Unkown
HY-175186 LO-3-62 Degrader / Unkown
HY-163864 PROTAC SMARCA2/4 degrader-11 Degrader / Unkown
HY-163865 PROTAC SMARCA2 degrader-13 Degrader / Unkown
HY-171765 SMARCA2/4-ligand-6 Ligand / Unkown
HY-159453 PROTAC SMARCA2/4 degrader-2 Degrader / Unkown
HY-162835 PROTAC SMARCA2/4 degrader-28 Degrader / Unkown
HY-161885 SMARCA2/4-IN-4 Inhibitor / Unkown
HY-159458 PROTAC SMARCA2/4 degrader-7 Degrader / Unkown
HY-159460 PROTAC SMARCA2/4 degrader-8 Degrader / Unkown
HY-170343 PROTAC SMARCA2 degrader-32 Degrader / Unkown
HY-178225 PROTAC SMARCA2/4 degrader-39 Degrader / Unkown
HY-159461 PROTAC SMARCA2/4 degrader-9 Degrader / Unkown
HY-163866 PROTAC SMARCA2/4 degrader-43 Degrader / Unkown
HY-W539427 BRM/BRG1 ligand 1 Ligand / Unkown
HY-159472 SMARCA2/4-ligand-1 Inhibitor / Unkown
HY-172446 SMARCA2/4-ligand-5 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smarca4 NCBI NCBI:6597