Aurka - aurora kinase A Gene

Also Known as IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20878

About Aurka

Chromosome 2: 172,198,110-172,212,455 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 34 phenotypes. Broad expression in liver E14.5 (RPKM 39.2), liver E14 (RPKM 37.7) and 15 other tissues.

Summary

Enables histone serine kinase activity and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including microtubule Cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine Cancer. Orthologous to human AURKA (Aurora Kinase A). [provided by Alliance of Genome Resources, Apr 2022]

Aurka Products (2)

mRNA Protein Name
NM_011497.4 NP_035627.1 aurora kinase A isoform a
NM_001291185.1 NP_001278114.1 aurora kinase A isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H3S10 kinase activity IMP
IMP: Inferred from mutant phenotype
21274965 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15793587 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
9245792 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
15793587 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axis specification IMP
IMP: Inferred from mutant phenotype
22939930 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
22939930 MGI
acts upstream of or within centrosome cycle IGI
IGI: Inferred from genetic interaction
17060449 MGI
acts upstream of or within centrosome localization IMP
IMP: Inferred from mutant phenotype
22832491 MGI
acts upstream of or within meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
21274965 MGI
acts upstream of or within meiotic spindle organization IMP
IMP: Inferred from mutant phenotype
14695913 MGI
acts upstream of or within microtubule cytoskeleton organization IGI
IGI: Inferred from genetic interaction
19668197 MGI
acts upstream of or within mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
15793587 MGI
acts upstream of or within mitotic centrosome separation IGI
IGI: Inferred from genetic interaction
17060449 MGI
acts upstream of or within mitotic centrosome separation IMP
IMP: Inferred from mutant phenotype
19075002 MGI
acts upstream of or within mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
18345035 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22939930 MGI
acts upstream of or within negative regulation of spindle checkpoint IMP
IMP: Inferred from mutant phenotype
19075002 MGI
acts upstream of or within neuron projection extension IGI
IGI: Inferred from genetic interaction
19668197 MGI
acts upstream of or within positive regulation of oocyte maturation IMP
IMP: Inferred from mutant phenotype
14695913 MGI
acts upstream of or within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17060449 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
17060449 MGI
acts upstream of or within protein localization to centrosome IMP
IMP: Inferred from mutant phenotype
17060449 MGI
acts upstream of or within protein phosphorylation IGI
IGI: Inferred from genetic interaction
17060449 MGI
acts upstream of or within spindle assembly involved in female meiosis I IMP
IMP: Inferred from mutant phenotype
21274965 MGI
Cellular Component GO Annotation Evidence References Source
located in axon hillock IDA
IDA: Inferred from direct assay
19668197 MGI
located in centrosome IDA
IDA: Inferred from direct assay
9245792 MGI
located in germinal vesicle IDA
IDA: Inferred from direct assay
14695913 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11980711 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
11980711 MGI
located in meiotic spindle IDA
IDA: Inferred from direct assay
14695913 MGI
located in microtubule organizing center IDA
IDA: Inferred from direct assay
27753540 MGI
located in microtubule organizing center IGI
IGI: Inferred from genetic interaction
19668197 MGI
located in mitotic spindle IDA
IDA: Inferred from direct assay
9245792 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
11980711 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
11980711 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
14695913 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
27753540 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aurka Protein Structure

PKc_like

PKc_like: cl21453 (117 - 373)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

aurora kinase A

  • aurora 2

  • aurora A

  • aurora family kinase 1

  • aurora-related kinase 1

  • aurora/IPL1-related kinase 1

  • ipl1- and aurora-related kinase 1

  • serine/threonine kinase 6

  • serine/threonine-protein kinase 15

  • serine/threonine-protein kinase 6

  • serine/threonine-protein kinase Ayk1

  • serine/threonine-protein kinase aurora-A

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-11103 Sitaxsentan sodium 98.83% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-157396 JAB-2485 99.87% Phase 2
HY-172737 RP-1664 Inhibitor 98.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (45)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112273 CD532 Inhibitor 98.86% Unkown
HY-103645 GW779439X 99.85% Unkown
HY-125956 Aurkin A 98.0% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-171767 SK2188 99.87% Unkown
HY-125911 Gossypin 98.29% Unkown
HY-171768 SK2187 Degrader 95.81% Unkown
HY-168543 PROTAC AURKA degrader 3 Degrader 99.78% Unkown
HY-112273A CD532 hydrochloride Inhibitor 99.62% Unkown
HY-100865 BPR1K871 Inhibitor 99.12% Unkown
HY-137344A dAURK-4 hydrochloride Degrader 98.14% Unkown
HY-175525 MS44 Degrader 99.89% Unkown
HY-181311 CCT400028 98.03% Unkown
HY-168540 PROTAC MPS1 degrader 1 99.90% Unkown
HY-180132 PROTAC AURKA degrader 2 Degrader 98.36% Unkown
HY-162469 6K465 Inhibitor 98.61% Unkown
HY-168545 SF-1 Ligand 99.50% Unkown
HY-114461B (3S,17S)-FD-895 / Unkown
HY-116190 CFI-401870 Inhibitor / Unkown
HY-125090 PHA-680626 / Unkown
HY-137344 dAURK-4 Degrader 99.93% Unkown
HY-147703 Aurora kinase inhibitor-9 Inhibitor / Unkown
HY-155464 VEGFR-2/AURKA-IN-1 Chemical / Unkown
HY-158038 AurkA allosteric-IN-1 / Unkown
HY-161407 AURKA-IN-1 Inhibitor / Unkown
HY-162837 AURKA against 1 Inhibitor / Unkown
HY-173499 HLDA-212 / Unkown
HY-175827 MK-5108-NH-PEG2-alkyne Inhibitor / Unkown
HY-175830 PROTAC AURKA degrader 1 Degrader / Unkown
HY-175982 AURKA-IN-3 Inhibitor / Unkown
HY-179375 LCI133 Inhibitor / Unkown
HY-179574 AURKA-IN-4 Inhibitor 99.88% Unkown
HY-179640 SK4454 Degrader / Unkown
HY-179641 SK5527 Degrader / Unkown
HY-181231 PROTAC CDK9 degrader-12 / Unkown
HY-181626 NN-01-195 / Unkown
HY-183098 UNC8209 / Unkown
HY-183100 UNC8461 Control / Unkown
HY-184329 PROTAC AURKB Degrader-1 / Unkown
HY-187195 Abd141 Degrader / Unkown
HY-187196 ATR/AURKA-ligand 1 Ligand / Unkown
HY-RS01266 AURKA Human Pre-designed siRNA Set A / Unkown
HY-RS01267 Aurka Mouse Pre-designed siRNA Set A / Unkown
HY-RS01268 Aurka Rat Pre-designed siRNA Set A / Unkown
HY-181568 PROTAC Aurora A Degrader-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurka NCBI NCBI:6790