BRD1 - bromodomain containing 1 Gene

Also Known as BRL; BRPF1; BRPF2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23774

About BRD1

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,773,278-49,827,873 (from NCBI)

This gene has 8 transcripts (splice variants), 277 orthologues and 8 paralogues. Broad expression in testis (RPKM 11.6), bone marrow (RPKM 4.4) and 25 other tissues.

Summary

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

BRD1 Products (10)

mRNA	Protein	Name
NM_001304808.3	NP_001291737.1	bromodomain-containing protein 1 isoform 1
NM_001304809.1	NP_001291738.1	bromodomain-containing protein 1 isoform 2
NM_001349940.2	NP_001336869.1	bromodomain-containing protein 1 isoform 3
NM_001349941.2	NP_001336870.1	bromodomain-containing protein 1 isoform 4
NM_001349942.2	NP_001336871.1	bromodomain-containing protein 1 isoform 5
NM_001394548.1	NP_001381477.1	bromodomain-containing protein 1 isoform 6
NM_001394549.1	NP_001381478.1	bromodomain-containing protein 1 isoform 7
NM_001394550.1	NP_001381479.1	bromodomain-containing protein 1 isoform 8
NM_001394551.1	NP_001381480.1	bromodomain-containing protein 1 isoform 2
NM_001394552.1	NP_001381481.1	bromodomain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to histone H3K14 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables histone binding	IDA IDA: Inferred from direct assay	21880731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27142060	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
part of histone H3-K14 acetyltransferase complex	IDA IDA: Inferred from direct assay	21753189	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10602503	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	21753189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD1 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

Bromodomain

PWWP

0
200
400
600
800
1000
1058 a.a.

Protein Preferred Names	Protein Names
bromodomain-containing protein 1	BR140-like protein

BRD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BRD1	O95696	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	BRD1	O95696	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	BRD1	O95696	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	BRD1	O95696	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	BRD1	O95696	CASP8	Homo sapiens	Q6NVI2	Validated Y2H	32296183
Intra	BRD1	O95696	CASP8	Homo sapiens	Q6NVI2	Y2H Array	32296183
Intra	BRD1	O95696	CASP8	Homo sapiens	Q6NVI2	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
Intra	BRD1	O95696	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
Intra	BRD1	O95696	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	RUBCN	Homo sapiens	Q92622	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	RUBCN	Homo sapiens	Q92622	Validated Y2H	32296183
Intra	BRD1	O95696	RUBCN	Homo sapiens	Q92622	Y2H Array	32296183
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Validated Y2H	32296183
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	BRD1	O95696	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	BRD1	O95696	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	BRD1	O95696	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	BRD1	O95696	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	BRD1	O95696	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	BRD1	O95696	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	BRD1	O95696	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

BRD1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89584	BRD1 Antibody (YA8928)	WB	human

Related Diseases

Diseases	Alias
Herpes Zoster Oticus	Nervus Intermedius Neuralgia Ramsay Hunt Syndrome Type 2 Geniculate Herpes Zoster Geniculate Neuralgia Herpes Zoster Auricularis Herpetic Geniculate Ganglionitis Ramsay Hunt Syndrome Type Ii Ramsey Hunt Syndrome Facial Nerve Palsy Due To Vzv Facial Nerve Palsy Due To Herpes Zoster Infection Facial Nerve Paralysis Due To Vzv Hunt Syndrome Hunt'S Syndrome Ramsay Hunt Syndrome Myoclonus And Ataxia
Nodular Prostate
Spinocerebellar Ataxia, X-Linked 5	SCAX5 X-Linked Spinocerebellar Ataxia 5 X-Linked Non Progressive Cerebellar Ataxia
Ohdo Syndrome, Sbbys Variant	Say-Barber-Biesecker-Young-Simpson Syndrome SBBYSS Young-Simpson Syndrome Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type Yss Sbbys Variant Of Ohdo Syndrome Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type Young Simpson Syndrome Sbbyss Syndrome Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type Bmrs Sbbys Ohdo Syndrome, Say-Barber-Biesecker Variant Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome Say-Barber-Biesecker Variant Of Ohdo Syndrome
Adult Brain Stem Glioma	Adult Brainstem Neuroglial Tumor
Ohdo Syndrome	Young Simpson Syndrome Ohdo Blepharophimosis Syndrome Blepharophimosis Syndrome Ohdo Type Blepharophimosis Intellectual Disability Syndromes Bmrs Blepharophimosis-Intellectual Disability Syndrome Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth Sbbys Syndrome Say Barber Biesecker Young-Simpson Syndrome Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type Bmrs, Ohdo Type Blepharophimosis Syndrome, Ohdo Type Ohdo-Madokoro-Sonoda Syndrome Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type Blepharophimosis - Intellectual Disability Syndrome
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Nut Midline Carcinoma	Nuclear Protein In Testis Midline Carcinoma Nmc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19537	NI-57	Inhibitor	99.42%	Unkown
HY-13959	MS436	Inhibitor	99.94%	Unkown
HY-18665	GSK-5959	Inhibitor	99.73%	Unkown
HY-111875	SNIPER(BRD)-1	Inhibitor	99.68%	Unkown
HY-RS01596	BRD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100670	Olinone	Inhibitor	/	Unkown
HY-122626	BRPF1B/TRIM24-IN-1	Inhibitor	/	Unkown
HY-RS18339	Brd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24818	Brd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BRD1	VGNC	VGNC:26556
Canis familiaris	BRD1	VGNC	VGNC:38518
Macaca mulatta	BRD1	VGNC	VGNC:70280
Mus musculus	BRD1	MGD	MGI:1924161
Rattus norvegicus	BRD1	RGD	RGD:1311855
Others	BRD1	NCBI