Comt - catechol-O-methyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24267

About Comt

Primary_assembly 11: 82,568,025-82,587,642 forward strand.mRatBN7.2:CM026984.1

This gene has 3 transcripts (splice variants), 276 orthologues, 2 paralogues and is associated with 68 phenotypes. Biased expression in Liver (RPKM 255.1), Kidney (RPKM 1227.4) and 5 other tissues.

Summary

Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of smooth muscle cell proliferation; and regulation of cellular amine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autoimmune disease of skin and connective tissue (multiple); bulimia nervosa; cognitive disorder (multiple); and reproductive organ Cancer (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Comt Products (1)

mRNA Protein Name
NM_012531.2 NP_036663.1 catechol O-methyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables catechol O-methyltransferase activity IDA
IDA: Inferred from direct assay
12584150 RGD
Biological Process GO Annotation Evidence References Source
involved in estrogen metabolic process IMP
IMP: Inferred from mutant phenotype
11071850 RGD
involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
18042640 RGD
involved in learning IMP
IMP: Inferred from mutant phenotype
15190105 RGD
involved in negative regulation of dopamine metabolic process IMP
IMP: Inferred from mutant phenotype
15190105 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
11071850 RGD
involved in positive regulation of homocysteine metabolic process IMP
IMP: Inferred from mutant phenotype
15779086 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
22100850 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
17573159 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15964593 RGD
involved in response to pain IMP
IMP: Inferred from mutant phenotype
17084978 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17868501 RGD
involved in short-term memory IMP
IMP: Inferred from mutant phenotype
22815336 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21846718 RGD
located in cell body IDA
IDA: Inferred from direct assay
21846718 RGD
located in dendrite IDA
IDA: Inferred from direct assay
21846718 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
7617303 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
7617303 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
7617303 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
7617303 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Comt Protein Structure

YrrM

YrrM: cl28097 (44 - 238)

  • 0
  • 100
  • 200
  • 265 a.a.
Protein Preferred Names Protein Names

catechol O-methyltransferase

  • catecholamine-O-methyltransferase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1473A Serotonin Inhibitor 99.86% Unkown
HY-B1473 Serotonin hydrochloride Inhibitor 99.97% Unkown
HY-17406 Tolcapone Inhibitor 99.86% Yes
HY-14280 Entacapone Inhibitor 99.97% Yes
HY-14896 Opicapone Inhibitor 98.81% Yes
HY-100562 Flopropione Inhibitor 99.97% Unkown
HY-B1473R Serotonin hydrochloride (Standard) Inhibitor 99.28% Unkown
HY-14280R Entacapone (Standard) Inhibitor 99.24% Unkown
HY-17406R Tolcapone (Standard) Inhibitor / Unkown
HY-14280A Entacapone sodium salt Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N0529 Rosmarinic acid Inhibitor 99.73% Phase 4
HY-106405 Nebicapone Inhibitor 99.89% Phase 2
HY-106842 Nitecapone Inhibitor 98.71% Phase 2
HY-19061 CGP 28014 Inhibitor / Phase 2
HY-109119 Neluxicapone Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B1473AS Serotonin-d4 Inhibitor 99.61% Unkown
HY-N0522 (-)-Gallocatechin gallate Inhibitor 99.97% Unkown
HY-B1473S Serotonin-d4 hydrochloride Inhibitor 99.48% Unkown
HY-133068 5-Hydroxyferulic acid 99.43% Unkown
HY-125339 Ro 41-0960 Inhibitor 98.22% Unkown
HY-100959 3,5-Dinitrocatechol Inhibitor 99.72% Unkown
HY-W012264 3-O-Methyldopa monohydrate 99.16% Unkown
HY-151388 hMAO-B/MB-COMT-IN-1 Inhibitor 98.04% Unkown
HY-157719 S-Adenosylhomocysteine sulfoxide Inhibitor ≥95.0% Unkown
HY-128410 4-Phenyl-7,8-dihydroxycoumarin Inhibitor 99.35% Unkown
HY-17406S1 Tolcapone-d4 Inhibitor 99.13% Unkown
HY-121949 U-0521 Inhibitor 98.67% Unkown
HY-14280S Entacapone-d10 Inhibitor 98.6% Unkown
HY-120325 DHMPA Inhibitor / Unkown
HY-W704878 (Z)-Entacapone-d10-1 / Unkown
HY-17406S Tolcapone-d7 Inhibitor / Unkown
HY-100642S1 3-O-Methyltolcapone-d4 Inhibitor / Unkown
HY-139089 (Z)-Entacapone Inhibitor / Unkown
HY-133068A (E)-5-Hydroxyferulic acid / Unkown
HY-100642S 3-O-Methyltolcapone-d7 Inhibitor 99.0% Unkown
HY-169611 Serotonin maleate Inhibitor / Unkown
HY-B1473S2 Serotonin-13C,D4 / Unkown
HY-162760 COMT-IN-1 Inhibitor / Unkown
HY-151390 hMAO-B/MB-COMT-IN-2 Inhibitor / Unkown
HY-168154 COMT-IN-2 Inhibitor / Unkown
HY-156069 Methylspinazarin Inhibitor / Unkown
HY-100642 3-O-Methyltolcapone Inhibitor 99.95% Unkown
HY-119224 BIA 3-335 Inhibitor / Unkown
HY-126194 Tolcapone 3-β-D-glucuronide Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Comt NCBI NCBI:1312