COMT - catechol-O-methyltransferase Gene

Also Known as HEL-S-98n

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1312

About COMT

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,941,772-19,969,975 (from NCBI)

This gene has 21 transcripts (splice variants), 276 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in placenta (RPKM 32.2), adrenal (RPKM 24.9) and 25 other tissues.

Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the Catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

COMT Products (5)

mRNA	Protein	Name
NM_001135161.2	NP_001128633.1	catechol O-methyltransferase isoform MB-COMT
NM_007310.3	NP_009294.1	catechol O-methyltransferase isoform S-COMT
NM_001362828.2	NP_001349757.1	catechol O-methyltransferase isoform MB-COMT
NM_000754.4	NP_000745.1	catechol O-methyltransferase isoform MB-COMT
NM_001135162.2	NP_001128634.1	catechol O-methyltransferase isoform MB-COMT

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables catechol O-methyltransferase activity	IDA IDA: Inferred from direct assay	11559542	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in catecholamine catabolic process	IDA IDA: Inferred from direct assay	11559542	GOA
involved in methylation	IDA IDA: Inferred from direct assay	11559542	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	11559542	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMT Protein Structure

Methyltransf_3

0
100
200
271 a.a.

Protein Preferred Names	Protein Names
catechol O-methyltransferase	epididymis secretory sperm binding protein Li 98n testicular tissue protein Li 42

COMT Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COMT	P21964	CCL4L1	Homo sapiens	Q8NHW4	Validated Y2H	32296183
Intra	COMT	P21964	AQP7	Homo sapiens	Q6P5T0	Y2H Array	32296183
Intra	COMT	P21964	AQP7	Homo sapiens	Q6P5T0	Y2H Prey Pooling	32296183
Intra	COMT	P21964	AQP7	Homo sapiens	Q6P5T0	Validated Y2H	32296183
Intra	COMT	P21964	S1PR3	Homo sapiens	Q99500	Y2H Prey Pooling	32296183
Intra	COMT	P21964	S1PR3	Homo sapiens	Q99500	Validated Y2H	32296183
Intra	COMT	P21964	S1PR3	Homo sapiens	Q99500	Y2H Array	32296183
Intra	COMT	P21964	HIBADH	Homo sapiens	P31937	Y2H Prey Pooling	32296183
Intra	COMT	P21964	HIBADH	Homo sapiens	P31937	Validated Y2H	32296183
Intra	COMT	P21964	HIBADH	Homo sapiens	P31937	Y2H Array	32296183
Intra	COMT	P21964	AVPR2	Homo sapiens	P30518	Validated Y2H	32296183
Intra	COMT	P21964	AVPR2	Homo sapiens	P30518	Y2H Array	32296183
Intra	COMT	P21964	AVPR2	Homo sapiens	P30518	Y2H Prey Pooling	32296183
Intra	COMT	P21964	PLPP6	Homo sapiens	Q8IY26	Y2H Prey Pooling	32296183
Intra	COMT	P21964	PLPP6	Homo sapiens	Q8IY26	Y2H Array	32296183
Intra	COMT	P21964	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	COMT	P21964	PGAP2	Homo sapiens	Q9UHJ9-5	Validated Y2H	32296183
Intra	COMT	P21964	RHBDL1	Homo sapiens	O75783	Y2H Prey Pooling	32296183
Intra	COMT	P21964	RHBDL1	Homo sapiens	O75783	Y2H Array	32296183
Intra	COMT	P21964	SLC48A1	Homo sapiens	Q6P1K1	Validated Y2H	32296183
Intra	COMT	P21964	SLC35A4	Homo sapiens	Q96G79	Validated Y2H	32296183
Intra	COMT	P21964	GJB4	Homo sapiens	Q9NTQ9	Validated Y2H	32296183
Intra	COMT	P21964	GJB4	Homo sapiens	Q9NTQ9	Y2H Array	32296183
Intra	COMT	P21964	GJB4	Homo sapiens	Q9NTQ9	Y2H Prey Pooling	32296183
Intra	COMT	P21964	OTOP3	Homo sapiens	Q7RTS5	Validated Y2H	32296183
Intra	COMT	P21964	SLC39A2	Homo sapiens	Q9NP94	Validated Y2H	32296183
Intra	COMT	P21964	SLC39A2	Homo sapiens	Q9NP94	Y2H Array	32296183
Intra	COMT	P21964	SLC39A2	Homo sapiens	Q9NP94	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TMEM50A	Homo sapiens	O95807	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TMEM50A	Homo sapiens	O95807	Y2H Array	32296183
Intra	COMT	P21964	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	COMT	P21964	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	COMT	P21964	TMEM187	Homo sapiens	Q14656	Validated Y2H	32296183
Intra	COMT	P21964	SLC7A8	Homo sapiens	Q9UHI5	Y2H Prey Pooling	32296183
Intra	COMT	P21964	SLC7A8	Homo sapiens	Q9UHI5	Validated Y2H	32296183
Intra	COMT	P21964	SLC7A8	Homo sapiens	Q9UHI5	Y2H Array	32296183
Intra	COMT	P21964	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	COMT	P21964	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	COMT	P21964	SLC35F1	Homo sapiens	Q5T1Q4	Validated Y2H	32296183
Intra	COMT	P21964	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	COMT	P21964	RHBDD2	Homo sapiens	Q6NTF9-3	Validated Y2H	32296183
Intra	COMT	P21964	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	COMT	P21964	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	COMT	P21964	FFAR3	Homo sapiens	O14843	Y2H Array	32296183
Intra	COMT	P21964	FFAR3	Homo sapiens	O14843	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TRHR	Homo sapiens	P34981	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TRHR	Homo sapiens	P34981	Validated Y2H	32296183
Intra	COMT	P21964	TRHR	Homo sapiens	P34981	Y2H Array	32296183
Intra	COMT	P21964	GPR42	Homo sapiens	O15529	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GPR42	Homo sapiens	O15529	Y2H Array	32296183
Intra	COMT	P21964	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	COMT	P21964	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	COMT	P21964	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	COMT	P21964	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	COMT	P21964	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	COMT	P21964	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	COMT	P21964	BEST2	Homo sapiens	Q8NFU1	Validated Y2H	32296183
Intra	COMT	P21964	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
Intra	COMT	P21964	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	COMT	P21964	SLC2A5	Homo sapiens	P22732	Validated Y2H	32296183
Intra	COMT	P21964	CNR2	Homo sapiens	P34972	Validated Y2H	32296183
Intra	COMT	P21964	CNR2	Homo sapiens	P34972	Y2H Array	32296183
Intra	COMT	P21964	CNR2	Homo sapiens	P34972	Y2H Prey Pooling	32296183
Intra	COMT	P21964	THSD7A	Homo sapiens	Q9UPZ6	Validated Y2H	32296183
Intra	COMT	P21964	TMEM222	Homo sapiens	Q9H0R3	Validated Y2H	32296183
Intra	COMT	P21964	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	COMT	P21964	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	COMT	P21964	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	COMT	P21964	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GJB3	Homo sapiens	O75712	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GJB3	Homo sapiens	O75712	Y2H Array	32296183
Intra	COMT	P21964	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	COMT	P21964	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	COMT	P21964	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	COMT	P21964	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	COMT	P21964	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	COMT	P21964	KCNK5	Homo sapiens	O95279	Y2H Array	32296183
Intra	COMT	P21964	KCNK5	Homo sapiens	O95279	Y2H Prey Pooling	32296183
Intra	COMT	P21964	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
Intra	COMT	P21964	SLC7A1	Homo sapiens	P30825	Validated Y2H	32296183
Intra	COMT	P21964	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
Intra	COMT	P21964	EMD	Homo sapiens	P50402	Validated Y2H	32296183
Intra	COMT	P21964	GPR161	Homo sapiens	Q8N6U8	Validated Y2H	32296183
Intra	COMT	P21964	GPR161	Homo sapiens	Q8N6U8	Y2H Prey Pooling	32296183
Intra	COMT	P21964	GPR161	Homo sapiens	Q8N6U8	Y2H Array	32296183
Intra	COMT	P21964	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	COMT	P21964	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TMEM205	Homo sapiens	Q6UW68	Anti Tag CoIP	33961781
Intra	COMT	P21964	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	COMT	P21964	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	COMT	P21964	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	COMT	P21964	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	COMT	P21964	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	COMT	P21964	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	COMT	P21964	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	COMT	P21964	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	COMT	P21964	SLC39A1	Homo sapiens	Q9NY26	Y2H Prey Pooling	32296183
Intra	COMT	P21964	SLC39A1	Homo sapiens	Q9NY26	Y2H Array	32296183
Intra	COMT	P21964	SLC39A1	Homo sapiens	Q9NY26	Validated Y2H	32296183
Intra	COMT	P21964	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	COMT	P21964	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	COMT	P21964	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	COMT	P21964	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	COMT	P21964	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	COMT	P21964	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	COMT	P21964	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	COMT	P21964	NIPAL4	Homo sapiens	Q0D2K0	Validated Y2H	32296183
Intra	COMT	P21964	SELENOK	Homo sapiens	Q9Y6D0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant COMT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72149	COMT Protein, Human (His)	P21964 (G52-P271)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74230	COMT Protein, Human (sf9, His)	P21964 (M51-P271)	≥ 90%, as determined by reducing SDS-PAGE.

COMT Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82269	COMT Antibody (YA2014)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Delusional Disorder	Persistent Delusional Disorders Delusional Perception Induced Delusional Disorder
Neonatal Abstinence Syndrome	Drug Withdrawal Syndrome In Newborn
Intermittent Explosive Disorder	Explosive Personality Disorder
Chromosomal Deletion Syndrome
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Cannabis Dependence	Marijuana Abuse Cannabinoid Addiction Cannabinoid Dependence Cannabis Addiction
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Neurotic Disorder	Neurosis Reactive Depression Adjustment Disorders Neurotic Disorders Depressive Neurosis Neurotic Depression Neurotic Depression Reactive Type Neurotic Depressive State Psychoneurosis Depressive Disorder Depression, Neurotic
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Borderline Personality Disorder
Ichthyosis, Congenital, Autosomal Recessive 9	Autosomal Recessive Congenital Ichthyosis 9 ARCI9 Ichthyosis, Congenital, Autosomal Recessive, Type 9
Substance-Induced Psychosis
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Bipolar I Disorder	Manic Depression Nos Manic-Depressive Illness Bipolar Disorder Nos
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Tardive Dyskinesia	Drug-Induced Tardive Dyskinesia Lingual-Facial-Buccal Dyskinesia Neuroleptic-Induced Tardive Dyskinesia
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Postpartum Depression	Maternity Blues Postnatal Depression Depression, Postpartum Post-Partum Depression Depression Postpartum
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Phobia, Specific	Specific Phobia Simple Phobia Phobia, Simple Isolated Phobia
Sexual Sadism	Sadism
Chromosomal Disease	Chromosomal Disorders Congenital Chromosomal Disease
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal 22q11.2 Distal Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2 ,Distal
Mycetoma	Madura Foot Mycetoma Of Foot
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Alexithymia
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Conversion Disorder	Conversion Hysteria Or Reaction Conversion Hysterical Neurosis Hysterical Neurosis, Conversion Type Fnd Functional Movement Disorder Functional Neurological Disorder Dissociative Disorder
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Panic Disorder 1	Panic Disorder Syndrome 1 PAND1 Panic Disorder Susceptibility Locus, Chromosome 13q-Related
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Schizophrenia 15	SCZD15 Schizophrenia 15 With Or Without An Affective Disorder Schizophrenia Susceptibility Locus, Chromosome 22q13-Related Schizophrenia Susceptibility Locus Chromosome 22q13-Related Schizophrenia, Type 15
Drug Dependence
Cannabis Abuse	Marijuana Abuse
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Brunner Syndrome	Monoamine Oxidase A Deficiency Antisocial Behavior BRNRS Deficiency Of Monoamine Oxidase A X-Linked Monoamine Oxidase Deficiency Susceptibility To Antisocial Behavior Antisocial Behavior, Susceptibility To Anti-Social Behavior
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Drug Psychosis	Drug-Induced Psychosis Drug-Induced Psychotic Disorder Psychoses, Substance-Induced Psychoses, Drug
Cyclothymic Disorder	Cyclothymia Cycloid Personality Cyclothymic Personality Affective Personality Disorder Cyclothymic Personality Disorder Cycloid Personality Disorder
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Schizophreniform Disorder	Schizophreniform Disorders Psychotic Disorders
Temporomandibular Joint Anomaly	Temporomandibular Joint Dysfunction Temporomandibular Joint Disorder Temporomandibular Joint Disease Temporomandibular Jaw Disorder Tmj - [Temporomandibular Joint] Disorder Temporomandibular Developmental Disorder Of Jaw Temporomandibular Dysfunction Temporomandibular Joint Syndrome Temporomandibular Joint-Pain-Dysfunction Syndrome Mandibular Dysfunction Nos Tmj - [Temporomandibular Joint Disorder] Syndrome Tmjpds - [Temporomandibular Joint Pain Dysfunction Syndrome] Tmj - [Temporomandibular Joint] Dysfunction
Specific Developmental Disorder
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Whiplash
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Cocaine Dependence
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Asperger Syndrome	Asperger Disorder
Chronic Pain
Chronic Fatigue Syndrome	Myalgic Encephalomyelitis Postviral Fatigue Syndrome Cfs Myalgic Encephalitis Encephalomyelitis, Myalgic Chronic Fatigue Fatigue Syndrome, Chronic Benign Myalgic Encephalomyelitis Akureyri Akureyri Disease Cfs - [Chronic Fatigue Syndrome] Epidemic Neuromyasthenia Myalgic Encephalomyelitis Syndrome Me - [Myalgic Encephalomyelitis] Pvfs - [Postviral Fatigue Syndrome] Neuromyasthenia Iceland Disease Icelandic Disease
Digeorge Syndrome	Chromosome 22q11.2 Deletion Syndrome DGS Hypoplasia Of Thymus And Parathyroids Third And Fourth Pharyngeal Pouch Syndrome 22q11.2 Deletion Syndrome Digeorge Sequence Digeorge'S Syndrome Pharyngeal Pouch Syndrome Di-George Syndrome Shprintzen Syndrome
Paraphilia Disorder	Paraphilia Paraphilias
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Conduct Disorder
Hallucinogen Dependence	Hallucinogen Addiction
Kleptomania	Pathological Stealing
Rem Sleep Behavior Disorder	Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behavior Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Separation Anxiety Disorder	Separation Anxiety Disorder Of Childhood
Hyperhomocysteinemia
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Constipation
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Obsessive-Compulsive Personality Disorder	Anankastic Personality Disorder Obsessive-Compulsive Personality Compulsive Personality Disorder Ocpd Obsessional Personality Disorder
Dissociative Disorder	Dissociative Disorders Dissociative Disease Dissociative Reaction
Paranoid Schizophrenia	Chronic Paranoid Schizophrenia Paranoid Type Schizophrenia Paranoid Type Schizophrenia Subchronic State Paraphrenia - Late Paraphrenic Schizophrenia Schizophrenia, Paranoid
Adenomyosis	Endometriosis Of Uterus Endometriosis Interna Endometriosis Of Myometrium Endometriosis, Myometrium Uterine Adenomyosis Adenomyosis Uteri Internal Endometriosis
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Melancholia
Premature Ejaculation
Heroin Dependence
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Schizotypal Personality Disorder	Schizotypal Personality
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Generalized Anxiety Disorder	Anxiety Generalized
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Polysubstance Abuse	Polysubstance Abuse, Susceptibility To Drug Addiction PSAB Drug Addiction, Susceptibility To Drug Dependence
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Aromatic L-Amino Acid Decarboxylase Deficiency	Aadc Deficiency Dopa Decarboxylase Deficiency Ddc Deficiency Aromatic Amino Acid Decarboxylase Deficiency Deficiency Of Aromatic-L-Amino-Acid Decarboxylase AADCD Aromatic-L-Amino-Acid Decarboxylase Deficiency Aromatic L-Amino-Acid Decarboxylase Deficiency
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Mixed Epithelial Stromal Tumour
Cholestasis, Intrahepatic, Of Pregnancy 3	ICP3 Cholestasis, Intrahepatic, Of Pregnancy, 3 Intrahepatic Cholestasis Of Pregnancy 3 Pregnancy Related Cholestasis 3 Cholestasis Of Pregnancy, Intrahepatic 3 Cholestasis, Intrahepatic, Of Pregnancy, Type 3
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Drug-Induced Mental Disorder
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 4 SRTD4 Atd4 Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 4
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Opiate Dependence	Opioid Dependence Opioid Addiction Opiate Addiction Opioid Type Dependence Opioid-Related Disorders Opium Dependence Narcotic Dependence Intravenous Narcotism Narcotism Nos Oral Narcotism Nos
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Agoraphobia	Fear Of Open Spaces Phobia Of Going Out
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Dysthymic Disorder	Dysthymia Chronic Depressive Disorder Chronic Depression Depressive Personality Depressive Personality Disorder Persistent Depressive Disorder Persistent Depression
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Carpal Tunnel Syndrome	Cts Carpal Tunnel Syndrome, Familial Carpal Tunnel Syndrome 1 CTS1 Amyotrophy, Thenar, Of Carpal Origin Carpal Tunnel Median Neuropathy Cts - Carpal Tunnel Syndrome Median Nerve Entrapment Carpal Canal Carpal Tunnel Compression Neuropathy, Carpal Tunnel Distal Median Nerve Compression Distal Median Nerve Entrapment Entrapment Neuropathy, Carpal Tunnel Median Neuropathy, Carpal Tunnel Median Neuropathy Carpal Tunnel Thenar Amyotrophy Of Crapal Origin
Flying Phobia
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Tic Disorder	Tics Behavioral Tic
Mood Disorder	Mood Disorders Episodic Mood Disorder
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Headache	Headache Disorder
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Mental Depression	Depression Depressive Disorder
Movement Disease	Movement Disorders Movement Disorder
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Substance Dependence
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1473A	Serotonin	Inhibitor	99.86%	Unkown
HY-B1473	Serotonin hydrochloride	Inhibitor	99.97%	Unkown
HY-17406	Tolcapone	Inhibitor	99.86%	Yes
HY-14280	Entacapone	Inhibitor	99.97%	Yes
HY-14896	Opicapone	Inhibitor	98.81%	Yes
HY-100562	Flopropione	Inhibitor	99.97%	Unkown
HY-B1473R	Serotonin hydrochloride (Standard)	Inhibitor	99.28%	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	99.24%	Unkown
HY-17406R	Tolcapone (Standard)	Inhibitor	/	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0529	Rosmarinic acid	Inhibitor	99.73%	Phase 3
HY-106405	Nebicapone	Inhibitor	99.89%	Phase 2
HY-106842	Nitecapone	Inhibitor	98.71%	Phase 2
HY-19061	CGP 28014	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1473AS	Serotonin-d4	Inhibitor	99.61%	Unkown
HY-N0522	(-)-Gallocatechin gallate	Inhibitor	99.97%	Unkown
HY-B1473S	Serotonin-d4 hydrochloride	Inhibitor	99.48%	Unkown
HY-133068	5-Hydroxyferulic acid		99.43%	Unkown
HY-125339	Ro 41-0960	Inhibitor	98.22%	Unkown
HY-100959	3,5-Dinitrocatechol	Inhibitor	99.72%	Unkown
HY-W012264	3-O-Methyldopa monohydrate		99.16%	Unkown
HY-151388	hMAO-B/MB-COMT-IN-1	Inhibitor	98.04%	Unkown
HY-157719	S-Adenosylhomocysteine sulfoxide	Inhibitor	≥95.0%	Unkown
HY-128410	4-Phenyl-7,8-dihydroxycoumarin	Inhibitor	99.35%	Unkown
HY-17406S1	Tolcapone-d4	Inhibitor	99.13%	Unkown
HY-121949	U-0521	Inhibitor	98.67%	Unkown
HY-14280S	Entacapone-d10	Inhibitor	98.6%	Unkown
HY-120325	DHMPA	Inhibitor	/	Unkown
HY-W704878	(Z)-Entacapone-d10-1		/	Unkown
HY-17406S	Tolcapone-d7	Inhibitor	/	Unkown
HY-139089	(Z)-Entacapone	Inhibitor	/	Unkown
HY-100642S1	3-O-Methyltolcapone-d4	Inhibitor	/	Unkown
HY-133068A	(E)-5-Hydroxyferulic acid		/	Unkown
HY-100642S	3-O-Methyltolcapone-d7	Inhibitor	99.0%	Unkown
HY-169611	Serotonin maleate	Inhibitor	/	Unkown
HY-B1473S2	Serotonin-13C,D4		/	Unkown
HY-109119	Neluxicapone	Inhibitor	/	Unkown
HY-162760	COMT-IN-1	Inhibitor	/	Unkown
HY-151390	hMAO-B/MB-COMT-IN-2	Inhibitor	/	Unkown
HY-168154	COMT-IN-2	Inhibitor	/	Unkown
HY-156069	Methylspinazarin	Inhibitor	/	Unkown
HY-100642	3-O-Methyltolcapone	Inhibitor	99.95%	Unkown
HY-119224	BIA 3-335	Inhibitor	/	Unkown
HY-126194	Tolcapone 3-β-D-glucuronide	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COMT	MGD	MGI:88470
Macaca mulatta	COMT	VGNC	VGNC:107781
Felis catus	COMT	VGNC	VGNC:61079
Canis familiaris	COMT	VGNC	VGNC:39501
Bos taurus	COMT	VGNC	VGNC:107259
Rattus norvegicus	COMT	RGD	RGD:2379
Others	COMT	NCBI