1. Gene
  2. COMT - catechol-O-methyltransferase Gene

COMT - catechol-O-methyltransferase Gene

Homo sapiens

Also known as HEL-S-98n

Gene ID: 1312 | Gene type: protein coding

About COMT

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:19,941,772-19,969,975 (from NCBI)

This gene has 21 transcripts (splice variants), 276 orthologues, 2 paralogues and is associated with 4 phenotypes. Ubiquitous expression in placenta (RPKM 32.2), adrenal (RPKM 24.9) and 25 other tissues.

Summary

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the Catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

COMT Products(5)

mRNA Protein Name
NM_001135161.2 NP_001128633.1 catechol O-methyltransferase isoform MB-COMT
NM_007310.3 NP_009294.1 catechol O-methyltransferase isoform S-COMT
NM_001362828.2 NP_001349757.1 catechol O-methyltransferase isoform MB-COMT
NM_000754.4 NP_000745.1 catechol O-methyltransferase isoform MB-COMT
NM_001135162.2 NP_001128634.1 catechol O-methyltransferase isoform MB-COMT

COMT Protein Structure

Methyltransf_3

Methyltransf_3: O-methyltransferase (81 - 225)

  • 0
  • 100
  • 200
  • 271 a.a.
Protein Preferred Names Protein Names

catechol O-methyltransferase

epididymis secretory sperm binding protein Li 98n

testicular tissue protein Li 42

Recombinant COMT Proteins

Cat. No. Product Name Accession Purity
HY-P72149 COMT Protein, Human (His) P21964 (G52-P271) ≥95%
HY-P74230 COMT Protein, Human (sf9, His) P21964 (M51-P271) ≥95%
HY-P74231 COMT Protein, Human P21964 (M51-P271) ≥95%

Related Diseases

Diseases Alias
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Delusional Disorder

Persistent Delusional Disorders

Delusional Perception

Induced Delusional Disorder

Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn

Intermittent Explosive Disorder

Explosive Personality Disorder

Chromosomal Deletion Syndrome
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Cannabis Dependence

Marijuana Abuse

Cannabinoid Addiction

Cannabinoid Dependence

Cannabis Addiction

Glossitis

Inflammation Of Tongue

Tongue Inflammation

Glazed Tongue

Neurotic Disorder

Neurosis

Reactive Depression

Adjustment Disorders

Neurotic Disorders

Depressive Neurosis

Neurotic Depression

Neurotic Depression Reactive Type

Neurotic Depressive State

Psychoneurosis

Depressive Disorder

Depression, Neurotic

Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Endogenous Depression

Clinical Depression

Unipolar Depression

Depressive Disorder

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor

Psychosomatic Disorder

Psychophysiologic Disorders

Borderline Personality Disorder
Ichthyosis, Congenital, Autosomal Recessive 9

Autosomal Recessive Congenital Ichthyosis 9

ARCI9

Ichthyosis, Congenital, Autosomal Recessive, Type 9

Substance-Induced Psychosis
Dementia

Dementias

Presenile Dementia

Alzheimer Type Dementia

Alzheimer Sclerosis

Alzheimer Disease Dementia

Alzheimer Dementia

Primary Degenerative Alzheimer Type Dementia

End Stage Alzheimer'S Dementia

Alzheimer'S Type Atypical Dementia

Alzheimer Type Presenile Dementia

Early Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 2

Dementia In Alzheimer Disease With Early Onset

Early Onset Alzheimer Type Dementia, Uncomplicated

Primary Degenerative Alzheimer Type Dementia, Early Onset

Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated

Alzheimer Disease Dementia With Early Onset

Presenile Sclerosis

Presenile Brain Sclerosis

Presenile Alzheimer Brain Sclerosis

Late Onset Alzheimer Dementia

Dementia In Alzheimer Disease Type 1

Dementia In Alzheimer Disease With Late Onset

Primary Degenerative Alzheimer Type Dementia, Late Onset

Sdat - [Senile Dementia, Alzheimer Type]

Alzheimer Disease Dementia With Late Onset

Late Onset Alzheimer Brain Sclerosis

Senile Alzheimer Brain Disease

Senile Alzheimer Brain Sclerosis

Senile Primary Degenerative Alzheimer Type Dementia

Senile Dementia Of The Alzheimer Type

Arteriosclerotic Dementia

Strategic-Infarct Dementia

Post Stroke Dementia

Vascular Cognitive Impairment

Vascular Dementia

Dementia Of The Lewy Body Type

Dementia With Lewy Bodies

Sdlt - [Senile Dementia Of The Lewy Body Type]

Senile Dementia Of The Lewy Body Type

Alcohol-Related Dementia

Alcoholic Dementia Nos

Alcohol-Induced Dementia

Alcoholic Brain Syndrome

Chronic Alcoholic Brain Syndrome

Alcohol Dementia

Late Onset Alcoholic Psychosis

Residual And Late-Onset Alcohol-Induced Psychotic Disorder

Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder

Late-Onset Psychoactive Substance-Induced Psychotic Disorder

Inhalant Dementia

Volatile Solvents Dementia

Dementia In Paralysis Agitans

Pdd - [Parkinson Disease Dementia]

Dementia Syndrome Of Parkinson Disease

Dementia In Parkinson Disease

Parkinson Related Dementia

Dementia In Huntington Chorea

Hiv - [Human Immunodeficiency Virus] Dementia

Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex

Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex

Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex

Aids Related Dementia

Dementia Due To Niacin Deficiency

Bipolar I Disorder

Manic Depression Nos

Manic-Depressive Illness

Bipolar Disorder Nos

Antisocial Personality Disorder

Dissocial Personality Disorder

Asocial Personality

Psychopath.Personality

Psychopathic Personality

Psychopathic Personality Disorder

Sociopathic Personality

Tardive Dyskinesia

Drug-Induced Tardive Dyskinesia

Lingual-Facial-Buccal Dyskinesia

Neuroleptic-Induced Tardive Dyskinesia

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Postpartum Depression

Maternity Blues

Postnatal Depression

Depression, Postpartum

Post-Partum Depression

Depression Postpartum

Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis

Post-Traumatic Stress Disorder

PTSD

Traumatic Neurosis

Post Traumatic Stress Disorder

Stress Disorders, Post-Traumatic

Posttraumatic Stress Disorder

Ptsd - [Post Traumatic Stress Disorder]

Trauma-Related Disorders

Phobia, Specific

Specific Phobia

Simple Phobia

Phobia, Simple

Isolated Phobia

Sexual Sadism

Sadism

Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome

Autosomal Dominant Opitz G/Bbb Syndrome

Catch22

Cayler Cardiofacial Syndrome

Conotruncal Anomaly Face Syndrome

Digeorge Syndrome

Sedlackova Syndrome

Shprintzen Syndrome

Velocardiofacial Syndrome

Distal 22q11.2 Microdeletion Syndrome

22q11.2ds

Vcfs

Velo-Cardio-Facial Syndrome

Distal Chromosome 22q11.2 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome Distal

22q11.2 Distal Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome

Deletion 22q11.2 Syndrome

22q11ds

Catch 22

Digeorge Sequence

Microdeletion 22q11.2

Monosomy 22q11

Takao Syndrome

Distal Del(22)(Q11.2)

Distal Monosomy 22q11.2

Catch 22 Syndrome

Chromosome Deletion Syndrome 22q11.2 ,Distal

Mycetoma

Madura Foot

Mycetoma Of Foot

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Impulse Control Disorder

Disruptive, Impulse Control, And Conduct Disorders

Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette

Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Alexithymia
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Conversion Disorder

Conversion Hysteria Or Reaction

Conversion Hysterical Neurosis

Hysterical Neurosis, Conversion Type

Fnd

Functional Movement Disorder

Functional Neurological Disorder

Dissociative Disorder

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Panic Disorder 1

Panic Disorder Syndrome 1

PAND1

Panic Disorder Susceptibility Locus, Chromosome 13q-Related

Velocardiofacial Syndrome

Shprintzen Syndrome

VCFS

Chromosome 22q11.2 Deletion Syndrome

Vcf Syndrome

Shprintzen Vcf Syndrome

Vcf-Velocardiofacial Syndrome

Velo-Cardio-Facial Syndrome

Digeorge Syndrome

22q11 Deletion Syndrome

Conotruncal Anomaly Face Syndrome

Dementia, Lewy Body

Lewy Body Dementia

Lewy Body Disease

Diffuse Lewy Body Disease

Dementia With Lewy Bodies

DLB

Autosomal Dominant Diffuse Lewy Body Disease

Cortical Lewy Body Disease

Dementia, Lewy Body, Susceptibility To

Lewy Body Dementia, Susceptibility To

Senile Dementia Of The Lewy Body Type

Dementia Of The Lewy Body Type

Lbd

Diffuse Lewy Body Disease With Gaze Palsy

Dysphasic Dementia Hereditary

Lewy Body Type Senile Dementia

Lewy Body Variant Of Alzheimer Disease

Lewy Bodies

Lewy Body

Dlbd - [Diffuse Lewy Body Disease]

Clbd - [Cortical Lewy Body Disease]

Schizophrenia 15

SCZD15

Schizophrenia 15 With Or Without An Affective Disorder

Schizophrenia Susceptibility Locus, Chromosome 22q13-Related

Schizophrenia Susceptibility Locus Chromosome 22q13-Related

Schizophrenia, Type 15

Drug Dependence
Cannabis Abuse

Marijuana Abuse

Bruxism

Sleep Bruxism

Sleep-Related Bruxism

Bruxism - Teeth Grinding

Grinding Teeth

Sleep Related Bruxism

Teeth Grinding

Sleep Related Teeth Grinding

Brunner Syndrome

Monoamine Oxidase A Deficiency

Antisocial Behavior

BRNRS

Deficiency Of Monoamine Oxidase A

X-Linked Monoamine Oxidase Deficiency

Susceptibility To Antisocial Behavior

Antisocial Behavior, Susceptibility To

Anti-Social Behavior

Panic Disorder

Panic Anxiety Syndrome

Panic

Panic Disorder 1

Episodic Paroxysmal Anxiety Disorder

Drug Psychosis

Drug-Induced Psychosis

Drug-Induced Psychotic Disorder

Psychoses, Substance-Induced

Psychoses, Drug

Cyclothymic Disorder

Cyclothymia

Cycloid Personality

Cyclothymic Personality

Affective Personality Disorder

Cyclothymic Personality Disorder

Cycloid Personality Disorder

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Temporomandibular Joint Anomaly

Temporomandibular Joint Dysfunction

Temporomandibular Joint Disorder

Temporomandibular Joint Disease

Temporomandibular Jaw Disorder

Tmj - [Temporomandibular Joint] Disorder

Temporomandibular Developmental Disorder Of Jaw

Temporomandibular Dysfunction

Temporomandibular Joint Syndrome

Temporomandibular Joint-Pain-Dysfunction Syndrome

Mandibular Dysfunction Nos

Tmj - [Temporomandibular Joint Disorder] Syndrome

Tmjpds - [Temporomandibular Joint Pain Dysfunction Syndrome]

Tmj - [Temporomandibular Joint] Dysfunction

Specific Developmental Disorder
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders

Whiplash
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Cocaine Dependence
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Asperger Syndrome

Asperger Disorder

Chronic Pain
Chronic Fatigue Syndrome

Myalgic Encephalomyelitis

Postviral Fatigue Syndrome

Cfs

Myalgic Encephalitis

Encephalomyelitis, Myalgic

Chronic Fatigue

Fatigue Syndrome, Chronic

Benign Myalgic Encephalomyelitis

Akureyri

Akureyri Disease

Cfs - [Chronic Fatigue Syndrome]

Epidemic Neuromyasthenia

Myalgic Encephalomyelitis Syndrome

Me - [Myalgic Encephalomyelitis]

Pvfs - [Postviral Fatigue Syndrome]

Neuromyasthenia

Iceland Disease

Icelandic Disease

Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome

Paraphilia Disorder

Paraphilia

Paraphilias

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Conduct Disorder
Hallucinogen Dependence

Hallucinogen Addiction

Kleptomania

Pathological Stealing

Rem Sleep Behavior Disorder

Rem Sleep Behaviour Disorder

Rapid Eye Movement Sleep Behavior Disorder

Rapid Eye Movement Sleep Behaviour Disorder

Rem - [Rapid Eye Movement] Behaviour Disorder

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Separation Anxiety Disorder

Separation Anxiety Disorder Of Childhood

Hyperhomocysteinemia
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior

Constipation
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder

Obsessive-Compulsive Personality

Compulsive Personality Disorder

Ocpd

Obsessional Personality Disorder

Dissociative Disorder

Dissociative Disorders

Dissociative Disease

Dissociative Reaction

Paranoid Schizophrenia

Chronic Paranoid Schizophrenia

Paranoid Type Schizophrenia

Paranoid Type Schizophrenia Subchronic State

Paraphrenia - Late

Paraphrenic Schizophrenia

Schizophrenia, Paranoid

Adenomyosis

Endometriosis Of Uterus

Endometriosis Interna

Endometriosis Of Myometrium

Endometriosis, Myometrium

Uterine Adenomyosis

Adenomyosis Uteri

Internal Endometriosis

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Melancholia
Premature Ejaculation
Heroin Dependence
Oppositional Defiant Disorder

Disorder

Oppositional Defiance

Behavioural Disorder

Oppositional Defiance

Disruptive Mood Dysregulation Disorder

Schizotypal Personality Disorder

Schizotypal Personality

Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia

Generalized Anxiety Disorder

Anxiety Generalized

Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic

Polysubstance Abuse

Polysubstance Abuse, Susceptibility To

Drug Addiction

PSAB

Drug Addiction, Susceptibility To

Drug Dependence

Major Depressive Disorder

Seasonal Affective Disorder

Unipolar Depression

Depression

MDD

Depressive Disorder

Unipolar Depression, Susceptibility To

Major Depressive Disorder 1

Major Depressive Disorder, Response To Citalopram Therapy In

Major Depressive Disorder 2

Winter Depression

Single Major Depressive Episode

Sad

Clinical Depression

Major Depression

Depressive Syndrome

Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment

Seasonal Affective Disorder, Susceptibility To

Recurrent Major Depression

Affective Disorder, Seasonal

Depression In A Seasonal Pattern

Depression

Seasonal

Major Depressive Disorder With A Seasonal Pattern

Seasonal Depression

Seasonal Mood Disorder

Mental Depression

Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Aromatic L-Amino Acid Decarboxylase Deficiency

Aadc Deficiency

Dopa Decarboxylase Deficiency

Ddc Deficiency

Aromatic Amino Acid Decarboxylase Deficiency

Deficiency Of Aromatic-L-Amino-Acid Decarboxylase

AADCD

Aromatic-L-Amino-Acid Decarboxylase Deficiency

Aromatic L-Amino-Acid Decarboxylase Deficiency

Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome

Mixed Epithelial Stromal Tumour
Cholestasis, Intrahepatic, Of Pregnancy 3

ICP3

Cholestasis, Intrahepatic, Of Pregnancy, 3

Intrahepatic Cholestasis Of Pregnancy 3

Pregnancy Related Cholestasis 3

Cholestasis Of Pregnancy, Intrahepatic 3

Cholestasis, Intrahepatic, Of Pregnancy, Type 3

Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Drug-Induced Mental Disorder
Leiomyoma

Leiomyomatous Neoplasm

Leiomyomatous Tumor

Leiomyomas

Fibroid Tumor

Uterine Fibroids

Short-Rib Thoracic Dysplasia 4 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 4

SRTD4

Atd4

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 4

Pathological Gambling

Compulsive Gambling

Gambling

Gambling, Pathological

Addiction

Betting

Addiction

Gambling

Betting

Pathological

Gambling

Dependence

Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To

Opiate Dependence

Opioid Dependence

Opioid Addiction

Opiate Addiction

Opioid Type Dependence

Opioid-Related Disorders

Opium Dependence

Narcotic Dependence

Intravenous Narcotism

Narcotism Nos

Oral Narcotism Nos

Social Phobia

Phobia, Social

Phobia Social

Phobic Anxiety Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos

Fibromyalgia

Diffuse Myofascial Pain Syndrome

Fibromyalgia Syndrome

Fibromyalgia-Fibromyositis Syndrome

Fibromyositis

Fibrositis

Fms

Myofascial Pain Syndrome

Myofascial Pain Syndromes

Agoraphobia

Fear Of Open Spaces

Phobia Of Going Out

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To

ANON

Anorexia Nervosa, Susceptibility To, 1

An

Anorexia Nervosa 1

An - [Anorexia Nervosa]

Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder

Bulimia Nervosa

Bulimia

Bulimia Nervosa, Susceptibility To

Binge Eating Disorder

BULN

Bn

Hyperorexia Nervosa

Bulimia Nervosa 2

BULN2

Susceptibility To Bulimia Nervosa

Bulimia Nervosa, Susceptibility To, Type 2

Bn - [Bulimia Nervosa]

Bulimia Nos

Bulimic

Bingeing

Binge Overeating

Bouts Of Overeating

Episodes Of Overeating

Dysthymic Disorder

Dysthymia

Chronic Depressive Disorder

Chronic Depression

Depressive Personality

Depressive Personality Disorder

Persistent Depressive Disorder

Persistent Depression

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Carpal Tunnel Syndrome

Cts

Carpal Tunnel Syndrome, Familial

Carpal Tunnel Syndrome 1

CTS1

Amyotrophy, Thenar, Of Carpal Origin

Carpal Tunnel Median Neuropathy

Cts - Carpal Tunnel Syndrome

Median Nerve Entrapment

Carpal Canal

Carpal Tunnel

Compression Neuropathy, Carpal Tunnel

Distal Median Nerve Compression

Distal Median Nerve Entrapment

Entrapment Neuropathy, Carpal Tunnel

Median Neuropathy, Carpal Tunnel

Median Neuropathy Carpal Tunnel

Thenar Amyotrophy Of Crapal Origin

Flying Phobia
Irritable Bowel Syndrome

Irritable Colon

Psychogenic Ibs

Ibs - [Irritable Bowel Syndrome]

Spastic Bowel Syndrome

Tic Disorder

Tics

Behavioral Tic

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Learning Disability

Learning Disabilities

Learning Disorders

Academic Skill Disorder

Learning Disorder

Headache

Headache Disorder

Trigeminal Neuralgia

Tic Douloureux

Trifacial Neuralgia

Trifocal Neuralgia

Neuralgia Of The Fifth Cranial Nerve

Neuralgia Of 5th Cranial Nerve

Infraorbital Neuralgia

Mental Depression

Depression

Depressive Disorder

Movement Disease

Movement Disorders

Movement Disorder

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

Substance Dependence
Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome

Personality Disorder

Personality Disorders

Character Disorder

Personality

Specific Personality Disorders

Enduring Personality Change After Psychiatric Illness

Schizoaffective Disorder

Schizo-Affective Psychosis

Schizo-Affective Type Schizophrenia

Schizoaffective Psychosis

Schizoaffective Schizophrenia

Schizophrenia, Schizo-Affective Type

Schizophreniform Psychosis, Affective Type

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus COMT MGD MGI:88470
Macaca mulatta COMT VGNC VGNC:107781
Felis catus COMT VGNC VGNC:61079
Canis familiaris COMT VGNC VGNC:39501
Bos taurus COMT VGNC VGNC:107259
Rattus norvegicus COMT RGD RGD:2379
Others COMT NCBI