Tolcapone-d₇ (Synonyms: Ro 40-7592 d₇)

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Tolcapone-d₇ is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

For research use only. We do not sell to patients.

Tolcapone-d<sub>7</sub> Chemical Structure

Tolcapone-d₇ Chemical Structure

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Description	Tolcapone-d₇ is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].
IC₅₀ & Target	COMT^[1] α-syn and Aβ42 oligomerization, fibrillogenesis^[2]
Molecular Weight	280.28
Formula	C₁₄H₄D₇NO₅
SMILES	O=C(C1=CC(O)=C(O)C([N+]([O-])=O)=C1)C2=C([2H])C([2H])=C(C([2H])([2H])[2H])C([2H])=C2[2H]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
References	[1]. Paterson NE, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res. 2011 Jan;69(1):41-50. [Content Brief] [2]. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolcapone-d₇Ro 40-7592 d₇Isotope-Labeled CompoundsCOMTAmyloid-βCatechol-O-methyltransferaseβ-amyloid peptideAβAbetaDeuteriumlabeledα-synAβ42oligomerizationfibrillogenesisInhibitorinhibitorinhibit

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Tolcapone-d7 (Synonyms: Ro 40-7592 d7)

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