Idh1 - isocitrate dehydrogenase (NADP(+)) 1 Gene

Also Known as IDPc

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24479

About Idh1

Primary_assembly 9: 66,534,146-66,563,708 reverse strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 231 orthologues, 1 paralogue and is associated with 38 phenotypes. Biased expression in Liver (RPKM 1633.7), Kidney (RPKM 1182.8) and 9 other tissues.

Summary

Enables NADP binding activity and isocitrate dehydrogenase (NADP+) activity. Involved in female gonad development; isocitrate metabolic process; and response to steroid hormone. Located in peroxisome. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic Cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Apr 2022]

Idh1 Products (1)

mRNA Protein Name
NM_031510.1 NP_113698.1 isocitrate dehydrogenase [NADP] cytoplasmic

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
17447164 RGD
enables isocitrate dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
17447164 RGD
Biological Process GO Annotation Evidence References Source
involved in 2-oxoglutarate metabolic process IDA
IDA: Inferred from direct assay
16489927 RGD
involved in female gonad development IEP
IEP: Inferred from expression pattern
8083215 RGD
involved in isocitrate metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
8486157 RGD
involved in response to steroid hormone IDA
IDA: Inferred from direct assay
8349575 RGD
Cellular Component GO Annotation Evidence References Source
located in peroxisome IDA
IDA: Inferred from direct assay
14561759 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Idh1 Protein Structure

PTZ00435

PTZ00435: PTZ00435 (0 - 410)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

isocitrate dehydrogenase [NADP] cytoplasmic

  • IDH

  • IDP

  • Isocitrate dehydrogenase 1, soluble

  • NADP(+)-specific ICDH

  • cytosolic NADP-isocitrate dehydrogenase

  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic

  • isocitrate dehydrogenase 1 (NADP+), soluble

  • oxalosuccinate decarboxylase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-18767 Ivosidenib Inhibitor 99.89% Yes
HY-104042 Vorasidenib Inhibitor 99.76% Yes
HY-114226 Olutasidenib Inhibitor 99.16% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-145594 Safusidenib Inhibitor 99.05% Phase 3
HY-104036 IDH-305 Inhibitor 99.15% Phase 2
HY-100020 BAY-1436032 Inhibitor 99.79% Phase 1
HY-131312 Crelosidenib Inhibitor / Phase 1
HY-131312A Crelosidenib gentisate Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18082 AGI-5198 Inhibitor 99.93% Unkown
HY-19540 GSK864 Inhibitor 99.91% Unkown
HY-128661 IDH1 Inhibitor 2 Inhibitor 98.70% Unkown
HY-112056 DIM-C-pPhCO2Me Inhibitor 99.29% Unkown
HY-128888 (R,R)-GSK321 Inhibitor 99.36% Unkown
HY-12475 Mutant IDH1-IN-1 Inhibitor 98.78% Unkown
HY-128888B (S,R)-GSK321 Control 98.62% Unkown
HY-18717 Mutant IDH1-IN-2 Inhibitor 98.50% Unkown
HY-150238 IDH1 Inhibitor 7 Inhibitor 99.46% Unkown
HY-110144 TC-E 5008 Inhibitor / Unkown
HY-123153 GSK990 Control / Unkown
HY-149359 IHMT-IDH1-053 Inhibitor / Unkown
HY-158319 Mutant IDH1/NAMPT-IN-1 Inhibitor / Unkown
HY-121916 ML309 Inhibitor / Unkown
HY-175213 Mutant IDH1-IN-7 Inhibitor / Unkown
HY-175770 mIDH1-IN-2 Inhibitor / Unkown
HY-120765 BRD2879 Inhibitor / Unkown
HY-100476 Mutant IDH1-IN-3 Inhibitor / Unkown
HY-162631 IDH1 Inhibitor 9 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Idh1 NCBI NCBI:3417