IDH1 - isocitrate dehydrogenase (NADP(+)) 1 Gene

Also Known as IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3417

About IDH1

Cytogenetic location: 2q34 Genomic coordinates (GRCh38): 2:208,236,227-208,255,071 (from NCBI)

Ubiquitous expression in adrenal (RPKM 116.0), liver (RPKM 110.2) and 23 other tissues.

Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These Enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the Other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the Other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

IDH1 Products (3)

mRNA	Protein	Name
NM_001282386.1	NP_001269315.1	isocitrate dehydrogenase [NADP] cytoplasmic
NM_001282387.1	NP_001269316.1	isocitrate dehydrogenase [NADP] cytoplasmic
NM_005896.4	NP_005887.2	isocitrate dehydrogenase [NADP] cytoplasmic

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19935646	GOA
enables isocitrate dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	10521434	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	19935646	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31983428	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19935646	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 2-oxoglutarate metabolic process	IDA IDA: Inferred from direct assay	19935646	GOA
involved in isocitrate metabolic process	IDA IDA: Inferred from direct assay	10521434	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	10521434	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	10521434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IDH1 Protein Structure

Iso_dh

0
100
200
300
414 a.a.

Protein Preferred Names	Protein Names
isocitrate dehydrogenase [NADP] cytoplasmic	NADP(+)-specific ICDH NADP-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, peroxisomal epididymis luminal protein 216 epididymis secretory protein Li 26 epididymis secretory sperm binding protein isocitrate dehydrogenase (NADP(+)) 1, cytosolic isocitrate dehydrogenase 1 (NADP+), soluble oxalosuccinate decarboxylase

IDH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IDH1	O75874	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	IDH1	O75874	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	IDH1	O75874	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	IDH1	O75874	CALM1	Homo sapiens	P0DP23	Anti Bait CoIP	31983428
Intra	IDH1	O75874	CALM1	Homo sapiens	P0DP23	SPR	31983428
Intra	IDH1	O75874	CALM1	Homo sapiens	P0DP23	NMR	31983428
Intra	IDH1	O75874	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
Intra	IDH1	O75874	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053
Intra	IDH1	O75874	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
Intra	IDH1	O75874	IDH1	Homo sapiens	O75874	X-Ray Diffraction	26436839
Intra	IDH1	O75874	IDH1	Homo sapiens	O75874	X-Ray Diffraction	19935646
Intra	IDH1	O75874	IDH1	Homo sapiens	O75874	Y2H	21516116
Intra	IDH1	O75874	IDH1	Homo sapiens	O75874	GMS	19935646
Intra	IDH1	O75874	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	IDH1	O75874	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	IDH1	O75874	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IDH1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70214	IDH1 Protein, Human (HEK293, His, Solution)	O75874 (M1-L414)	≥ 95%, as determined by reducing SDS-PAGE.

IDH1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80995	IDH1 Antibody (YA3516)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P83868	IDH1 Antibody (YA3565)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey
HY-P83868A	IDH1 Antibody (YA3565)(PBS only)	WB, ICC/IF, FC, ELISA	Human, Mouse, Monkey

Related Diseases

Diseases	Alias
Cerebellar Astrocytoma	Astrocytoma Of Cerebellum
Clear Cell Chondrosarcoma	Chondrosarcoma, Clear Cell
Klatskin'S Tumor	Klatskin Tumor Hilar Cholangiocarcinoma Perihilar Cholangiocarcinoma Hilar Cholangiocellular Carcinoma Klatskin Tumour Klatskin'S Tumour Perihilar Extrahepatic Bile Duct Carcinoma Hilar Cca Adenocarcinoma Of Hepatic Duct Klatskin Tumour Of Biliary Tree
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Subependymal Glioma	Mixed Subependymoma-Ependymoma Subependymal Astrocytoma Who Grade I Ependymal Tumor Glioma, Subependymal
Sinonasal Undifferentiated Carcinoma	Highly Aggressive Undifferentiated Carcinoma Of The Nasal Cavity And Paranasal Sinuses Snuc
Chordoid Glioma	Chordoid Glioma Of The Third Ventricle
Adult Astrocytic Tumour	Adult Astrocytoma Adult Astrocytic Tumors
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Brain Stem Cancer	Brain Stem Neoplasms Malignant Neoplasm Of Brain Stem Malignant Neoplasm Of Brainstem Neoplasm Of Adult Brain Stem Neoplasm Of Brain Stem Primary Brain Stem Neoplasm Primary Brain Stem Tumor Brain Stem Neoplasm Brain Stem--Cancer Brain Stem Neoplasms, Primary
Diffuse Astrocytoma	Diffuse Astrocytoma, Low Grade Who Grade Ii Astrocytoma Fibrillary Astrocytoma Gemistocytic Astrocytoma Low-Grade Diffuse Astrocytoma Protoplasmic Astrocytoma
Central Nervous System Benign Neoplasm	Benign Neoplasm Of The Central Nervous System
Central Neurocytoma	Neurocytoma Neurolipocytoma Neurocytoma Central
Idh-Wildtype Glioblastoma
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Optic Nerve Astrocytoma	Astrocytic Tumor Of Optic Nerve Optic Tract Astrocytoma Visual Pathway Astrocytoma
Idh-Mutant Glioblastoma
Benign Ependymoma	Ependymoma Epithelial Ependymoma Who Grade Ii Ependymal Tumor Myxopapillary Ependymoma
Cerebellum Cancer	Cerebellar Neoplasms Cerebellar Cancer Malignant Tumor Of Cerebellum Malignant Neoplasm Of Cerebellum
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Anaplastic Oligodendroglioma
Infratentorial Cancer	Infratentorial Neoplasms Brain Neoplasm, Infratentorial Malignant Infratentorial Tumors
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Mixed Glioma	Mixed Gliomas Mixed Neuroglial Tumor Glioma
D-2-Hydroxyglutaric Aciduria 2	D2HGA2 D-2-Hydroxyglutaric Aciduria, Type 2
Giant Cell Glioblastoma	Monstrocellular Sarcoma
Intrahepatic Cholangiocarcinoma	Cholangiocarcinoma Intrahepatic Bile Duct Carcinoma Peripheral Cholangiocarcinoma Peripheral Intrahepatic Cholangiocarcinoma Adenocarcinoma Of Intra-Hepatic Bile Ducts Cholangiocarcinoma, Unspecified Site Cholangiocarcinoma Of Liver
Adult Oligodendroglioma	Adult Brain Oligodendroglioma Grade Ii Adult Oligodendroglial Tumor Oligodendroglioma, Adult
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Gangliocytoma	Ganglioneuroma Gangliocytoma Of Central Nervous System
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Bile Duct Disease	Bile Duct Diseases Bile Duct Disorder Disorder Of Bile Duct
Childhood Brain Stem Glioma	Pediatric Glioma Of The Brainstem
Glioma
Chondroma	Central Chondroma Enchondroma
Anaplastic Oligodendroglioma, Idh-Mutant And 1p/19q-Codeleted
Hemangioma	Hemangiomas
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Chondroblastic Osteosarcoma	Chondrosarcomatous Osteogenic Sarcoma
Frontal Lobe Neoplasm	Neoplasm Of Frontal Lobe Malignant Neoplasm Of Frontal Lobe Tumor Of Frontal Lobe
Enchondroma
Pilocytic Astrocytoma	Juvenile Pilocytic Astrocytoma Grade I Astrocytic Tumor Piloid Astrocytoma
Low Grade Glioma	Benign Glioma
Juxtacortical Chondroma	Periosteal Chondroma
Glioma Susceptibility 1	Astrocytoma GLM1 Glioma, Susceptibility To, Somatic Glioblastoma, Somatic Glioma Glioblastoma Multiforme Oligodendroglioma Glioma Somatic Astrocytic Tumor GLM Familial Glioma Of Brain Gbm Glioma 1 Glioma, Susceptibility, Type 1 Cerebral Astrocytoma Glioblastoma Well Differentiated Oligodendroglioma
Suppression Of Tumorigenicity 12	Prostate Adenocarcinoma Adenocarcinoma Of Prostate ST12 Prostate Adenocarcinoma 1 Pac1
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Spindle Cell Hemangioma	Sch Spindle Cell Hemangioendothelioma
Spinal Cord Oligodendroglioma	Oligodendroglioma Of Spinal Cord Well Differentiated Spinal Cord Oligodendroglioma
Anaplastic Astrocytoma	Grade Iii Astrocytoma Grade Iii Astrocytic Tumor Astrocytoma, Anaplastic
Spinal Disease	Spinal Disorder Spinal Diseases
Angioimmunoblastic T-Cell Lymphoma	Immunoblastic Lymphadenopathy Lymphogranulomatosis X T-Cell Lymphoma, Aild Type Aitl Ailt Angioimmunoblastic Lymphadenopathy Aild - [Angioimmunoblastic Lymphadenopathy With Dysproteinaemia] Angioimmunoblastic Lymphoma
Astroblastoma	Cerebral Astroblastoma
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Gemistocytic Astrocytoma	Gemistocytic Astrocytic Tumor
Spinal Cord Astrocytoma	Astrocytoma Of Spinal Cord Spinal Astrocytoma
Cholangiolocellular Carcinoma
Juvenile Pilocytic Astrocytoma
Plasma Cell Neoplasm	Plasma Cell Dyscrasia Paraproteinemias Plasma Cell Tumour Plasmacytic Tumor Multiple Myeloma Plasmacytoma Plasma Cell Tumours Plasma Cells Dyscrasia
Cerebral Ventricle Cancer	Cerebral Ventricle Neoplasms Cerebral Ventricle Neoplasm Intraventricular Tumor Of Brain
Bile Duct Cancer	Bile Duct Carcinoma Extrahepatic Bile Duct Carcinoma Carcinoma Of Extrahepatic Bile Duct Extrahepatic Bile Duct Cancer Bile Duct Neoplasms Bile Duct Tumor Ca Extrahepatic Bile Ducts Malignant Neoplasm Of The Extrahepatic Bile Duct Bile Duct Extrahepatic Carcinoma Malignant Tumor Of Extrahepatic Bile Duct
Brain Stem Glioma	Brainstem Neuroglial Tumor Brainstem Glioma Glioma Of Brainstem
Central Nervous System Cancer	Central Nervous System Tumor Central Nervous System Tumors Cns Neoplasm Malignant Neoplasm Of Central Nervous System Malignant Tumor Of Cns Neoplasm Of Central Nervous System Malignant Neoplasm Of The Central Nervous System Neoplasm Of The Central Nervous System Central Nervous System Neoplasms Central Nervous System Neoplasm
Internal Auditory Canal Lipoma	Lipoma Of The Internal Auditory Canal Inner Ear Lipoma
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Pleomorphic Xanthoastrocytoma	Pxa Pleomorphic Xantho-Astrocytoma
Oligodendroglioma	Oligodendroglial Neoplasm Oligodendroglial Tumor Oligodendroglial Tumors Well Differentiated Oligodendroglioma
Gliomatosis Cerebri	Astrocytosis Cerebri Neoplasms, Neuroepithelial
Histone Mutated Tumor	Histone Mutated Tumour
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Bile Duct Adenocarcinoma
Papillary Craniopharyngioma	Craniopharyngioma, Papillary Papillary Rathke'S Pouch Tumor Craniopharyngioma Papillary
Subependymal Giant Cell Astrocytoma	Sega Astrocytoma Subependymal Giant Cell Subependymal Giant-Cell Astrocytoma
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Supratentorial Ependymoma
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Mucinous Intrahepatic Cholangiocarcinoma	Mucin-Producing Intrahepatic Cholangiocarcinoma
Anaplastic Pleomorphic Xanthoastrocytoma
Idh-Wildtype Anaplastic Astrocytoma
Spinal Cord Glioma	Glial Tumor Of Spinal Cord Glial Neoplasm Spinal Cord Glioma Of Spinal Cord
Glioblastoma Classical Subtype
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Diffuse Midline Glioma, H3 K27m-Mutant	Diffuse Intrinsic Pontine Glioma Dipg Infiltrative Brainstem Glioma
Metaphyseal Enchondromatosis With D-2-Hydroxyglutaric Aciduria	Metaphyseal Chondromatosis With D-2-Hydroxyglutaric Aciduria Spondyloenchondromatosis With D-2-Hydroxyglutaric Aciduria Metaphyseal Enchondrodysplasia With 2-Hydroxyglutaric Aciduria
Temporal Lobe Neoplasm	Neoplasm Of Temporal Lobe Malignant Neoplasm Of Temporal Lobe Tumor Of Temporal Lobe
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Connective Tissue Cancer	Neoplasms, Connective Tissue Connective Tissue Neoplasm Mesenchymal Tissue Malignant Neoplasm Neoplasm Of Connective Tissues Tumour Of Connective Tissue
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
High Grade Ependymoma	Ependymal Neoplasm Ependymal Tumors Malignant Ependymoma Ependymal Tumor Anaplastic Ependymoma Experimental Organism Malignant Ependymoma Ependymoma Of Brain
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Paroxysmal Extreme Pain Disorder	PEPD Familial Rectal Pain Pexpd Submandibular, Ocular, And Rectal Pain With Flushing Pain, Submandibular, Ocular, And Rectal, With Flushing Rectal Pain, Familial Submandibular, Ocular And Rectal Pain With Flushing Familial Rectal Syndrome Frp Pain Disorder, Paroxysmal, Extreme
Anaplastic Ependymoma	Ependymoma, Anaplastic Undifferentiated Ependymoma
Paranasal Sinus Cancer	Paranasal Sinus Adenoid Cystic Carcinoma Paranasal Sinus Mucoepidermoid Carcinoma Paranasal Sinus Squamous Cell Carcinoma Paranasal Sinus Neoplasms Adenoid Cystic Carcinoma Of Accessory Sinus Adenoid Cystic Carcinoma Of Paranasal Sinus Epidermoid Carcinoma Of The Paranasal Sinus Mucoepidermoid Carcinoma Of Accessory Sinus Paranasal Sinus Adenocarcinoma Squamous Cell Carcinoma Of Paranasal Sinus Paranasal Sinus Neoplasm Adenocarcinoma Of Accessory Sinus
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Rela Fusion-Positive Ependymoma	Supratentorial C11orf95-Rela Fused Ependymoma C11orf95 Fusion-Positive Supratentorial Ependymoma
Brain Stem Astrocytic Neoplasm	Brainstem Astrocytoma Astrocytoma Of Brain Stem
Adult Central Nervous System Primitive Neuroectodermal Neoplasm	Adult Cns Pnet Adult Central Nervous System Primitive Neuroectodermal Tumor
Spinal Cancer	Spinal Cord Neoplasm Spinal Cord Neoplasms Spinal Neoplasms Intraspinal Tumor Malignant Tumor Of The Spinal Cord Spinal Cord Cancer Spinal Neoplasm Tumor Of The Spinal Cord Tumors Spinal Cord Intraspinal Neoplasm Spinal Cord--Cancer
Histoplasmosis Meningitis	Histoplasmosis With Meningitis Histoplasmosis, Unspecified, Meningitis
Gliosarcoma	Glioblastoma With Sarcomatous Component Sarcomatous Glioblastoma
Nasal Cavity Cancer	Nasal Cavity Carcinoma Malignant Neoplasm Of Nasal Cavities Malignant Tumor Of The Nasal Cavity Cancer Of Nasal Cavity Carcinoma Of Nasal Cavity Malignant Neoplasm Of Nasal Cavity Neoplasm Of Nasal Cavity
Pancreatic Serous Cystadenocarcinoma	Serous Cystadenocarcinoma Of Pancreas
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Brain Glioma	Lower Grade Glioma Intracranial Glioma Glioma Nos
Cell Type Benign Neoplasm
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
2-Hydroxyglutaric Aciduria	2-Hga 2-Hydroxyglutaric Acidemia 2-Hydroxyglutaricaciduria Combined D-2- And L-2-Hydroxyglutaric Aciduria
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Periosteal Chondrosarcoma	Juxtacortical Chondrosarcoma
Bone Sarcoma
Intracranial Chondrosarcoma
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Pilocytic Astrocytoma Of Cerebellum	Cerebellar Pilocytic Astrocytoma
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Malignant Astrocytoma	Astrocytic Tumor Astrocytoma Of Brain Astrocytoma Of Cerebrum Astroglioma Cerebral Astrocytoma Astrocytoma
Multiple Enchondromatosis, Maffucci Type	Maffucci Syndrome Chondrodysplasia With Hemangioma Chondroplasia Angiomatosis Enchondromatosis With Hemangiomata Hemangiomatosis Chondrodystrophica Kast Syndrome Multiple Angiomas And Endochondromas Dyschondrodysplasia With Hemangiomas Enchondromatosis Type Ii Enchondromatosis With Multiple Cavernous Hemangiomas Dyschondroplasia And Cavernous Hemangioma Hemangiomata With Dyschondroplasia
D-2-Hydroxyglutaric Aciduria 1	D-2-Hydroxyglutaric Aciduria D2HGA1 D-2-Hga D-2-Hydroxyglutaric Acidemia D2ha D2hga Aciduria, D-2-Hydroxyglutaric, Type 1 Combined D-2- And L-2-Hydroxyglutaric Aciduria
Fibrillary Astrocytoma	Fibrillary Astrocytic Tumors Diffuse Astrocytoma Gemistocytic Astrocytoma Protoplasmic Astrocytoma
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Idh-Mutant Anaplastic Astrocytoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Enchondromatosis, Multiple, Ollier Type	Ollier Disease Enchondromatosis Dyschondroplasia Osteochondromatosis Multiple Cartilaginous Enchondroses Multiple Enchondromatosis Enchondromatosis With Haemangiomata Enchondromatosis, Multiple Kast'S Syndrome Ollier'S Syndrome Enchondromatosis Multiple ENCHOM Maffucci Disease Olliers Disease Hereditary Multiple Exostoses Chondromatosis
Adult Brain Stem Glioma	Adult Brainstem Neuroglial Tumor
Mixed Oligodendroglioma-Astrocytoma	Who Grade Ii Mixed Glioma
L-2-Hydroxyglutaric Aciduria	L-2-Hydroxyglutaric Acidemia L2HGA L-2-Hga Aciduria, L-2-Hydroxyglutaric Combined D-2- And L-2-Hydroxyglutaric Aciduria
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Pilomyxoid Astrocytoma
Childhood Oligodendroglioma	Pediatric Oligodendroglioma Oligodendroglioma, Childhood
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Simple Partial Epilepsy	Epilepsy, Simple Partial
Spinal Cord Disease	Spinal Cord Diseases Myelopathy Bone Marrow Diseases
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Dysembryoplastic Neuroepithelial Tumor	Dysembryoplastic Neuroepithelial Neoplasm Dysembryoplastic Neuroepithelial Tumour Dnet
Cerebral Lymphoma	Primary Cerebral Lymphoma Brain Primary Lymphoma Primary Lymphoma Of Cerebrum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18767	Ivosidenib	Inhibitor	99.89%	Yes
HY-104042	Vorasidenib	Inhibitor	99.76%	Yes
HY-114226	Olutasidenib	Inhibitor	99.16%	Yes

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145594	Safusidenib	Inhibitor	99.05%	Phase 3
HY-104036	IDH-305	Inhibitor	99.15%	Phase 2
HY-100020	BAY-1436032	Inhibitor	99.79%	Phase 1
HY-131312	Crelosidenib	Inhibitor	/	Phase 1
HY-131312A	Crelosidenib gentisate	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18082	AGI-5198	Inhibitor	99.93%	Unkown
HY-19540	GSK864	Inhibitor	99.91%	Unkown
HY-128661	IDH1 Inhibitor 2	Inhibitor	98.70%	Unkown
HY-112056	DIM-C-pPhCO2Me	Inhibitor	99.29%	Unkown
HY-128888	(R,R)-GSK321	Inhibitor	99.36%	Unkown
HY-12475	Mutant IDH1-IN-1	Inhibitor	98.78%	Unkown
HY-128888B	(S,R)-GSK321	Control	98.62%	Unkown
HY-18717	Mutant IDH1-IN-2	Inhibitor	98.50%	Unkown
HY-150238	IDH1 Inhibitor 7	Inhibitor	99.46%	Unkown
HY-110144	TC-E 5008	Inhibitor	/	Unkown
HY-123153	GSK990	Control	/	Unkown
HY-149359	IHMT-IDH1-053	Inhibitor	/	Unkown
HY-158319	Mutant IDH1/NAMPT-IN-1	Inhibitor	/	Unkown
HY-121916	ML309	Inhibitor	/	Unkown
HY-175213	Mutant IDH1-IN-7	Inhibitor	/	Unkown
HY-175770	mIDH1-IN-2	Inhibitor	/	Unkown
HY-120765	BRD2879	Inhibitor	/	Unkown
HY-100476	Mutant IDH1-IN-3	Inhibitor	/	Unkown
HY-162631	IDH1 Inhibitor 9	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IDH1	RGD	RGD:2862
Canis familiaris	IDH1	VGNC	VGNC:110512
Felis catus	IDH1	VGNC	VGNC:80241
Mus musculus	IDH1	MGD	MGI:96413
Macaca mulatta	IDH1	VGNC	VGNC:99371
Others	IDH1	NCBI