2. Gene
  3. Nras - NRAS proto-oncogene, GTPase Gene

Nras - NRAS proto-oncogene, GTPase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24605 | Gene type: protein coding

About Nras

Primary_assembly 2: 190,582,918-190,591,626 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 152 orthologues, 41 paralogues and is associated with 72 phenotypes. Biased expression in Thymus (RPKM 212.1), Lung (RPKM 23.5) and 9 other tissues.

Summary

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland Cancer (multiple); hematologic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Nras Products(1)

mRNA Protein Name
NM_080766.2 NP_542944.1 GTPase NRas

Nras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

GTPase NRas

neuroblastoma RAS viral (v-ras) oncogene homolog

neuroblastoma RAS viral oncogene homolog

neuroblastoma ras oncogene

transforming protein N-Ras

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15136 Lonafarnib 99.87% Yes
Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156498 RMC-7977 Inhibitor 99.12% Unkown
HY-15217 CHR-6494 Inhibitor 98.07% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.16% Unkown
HY-142161 ABD957 Inhibitor 99.46% Unkown
HY-158115 NST-628 Inhibitor / Unkown
HY-122866 ZT-12-037-01 Inhibitor 98.67% Unkown
HY-156228 RGB-1 98.07% Unkown
HY-107415 PLX7922 Inhibitor 98.00% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-110350 CHR-6494 TFA Inhibitor / Unkown
HY-120911 Palmostatin B Inhibitor / Unkown
HY-12847 CCT241161 / Unkown
HY-149705 ICMT-IN-7 Inhibitor / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-156500 ICMT-IN-1 Inhibitor / Unkown
HY-163515 Anticancer agent 207 Inhibitor / Unkown
HY-RS09558 NRAS Human Pre-designed siRNA Set A / Unkown
HY-RS09559 Nras Mouse Pre-designed siRNA Set A / Unkown
HY-RS09560 Nras Rat Pre-designed siRNA Set A / Unkown
HY-101641 NRA-0160 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nras NCBI NCBI:4893