Nras - NRAS proto-oncogene, GTPase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24605

About Nras

Primary_assembly 2: 190,582,918-190,591,626 forward strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 152 orthologues, 41 paralogues and is associated with 72 phenotypes. Biased expression in Thymus (RPKM 212.1), Lung (RPKM 23.5) and 9 other tissues.

Summary

Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; defense response to protozoan; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland Cancer (multiple); hematologic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human NRAS (NRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Nras Products (1)

mRNA Protein Name
NM_080766.2 NP_542944.1 GTPase NRas

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19319189 RGD
Biological Process GO Annotation Evidence References Source
involved in myoblast differentiation IEP
IEP: Inferred from expression pattern
2425941 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

GTPase NRas

  • neuroblastoma RAS viral (v-ras) oncogene homolog

  • neuroblastoma RAS viral oncogene homolog

  • neuroblastoma ras oncogene

  • transforming protein N-Ras

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15136 Lonafarnib 99.85% Yes
HY-B0984 Fendiline hydrochloride 99.78% Unkown
HY-B0984A Fendiline 99.41% Unkown
HY-B0984R Fendiline hydrochloride (Standard) 99.76% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-176785S MCB-294 98.04% Phase 4
HY-148439 Daraxonrasib Inhibitor 99.96% Phase 3
HY-158115 NST-628 Inhibitor 99.35% Phase 1
HY-173632 AMG410 Inhibitor 99.75% Phase 1

Pre-clinical Phase

Bioactive Molecules (40)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156498 RMC-7977 Inhibitor 99.48% Unkown
HY-15217 CHR-6494 Inhibitor 99.28% Unkown
HY-142161 ABD957 Inhibitor 98.14% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.57% Unkown
HY-176786 MCB-36 98.43% Unkown
HY-202699 SHOC2-RAS PPI-IN-1 Inhibitor 99.50% Unkown
HY-122866 ZT-12-037-01 Inhibitor 98.06% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-175870 Eras-4001 Inhibitor 98.27% Unkown
HY-156228 RGB-1 Inhibitor / Unkown
HY-181420A BBO-11818 99.77% Unkown
HY-107415 PLX7922 Inhibitor 98.68% Unkown
HY-156500 ICMT-IN-1 Inhibitor 98.43% Unkown
HY-168847 INCB159020 Inhibitor / Unkown
HY-12847 CCT241161 99.77% Unkown
HY-RS09559 Nras Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181555 IACS-56676 Inhibitor / Unkown
HY-15872 FTI-277 / Unkown
HY-164524 SBI-0640726 Inhibitor 99.57% Unkown
HY-108887 Anticancer agent 124 Inhibitor / Unkown
HY-110350 CHR-6494 TFA Inhibitor / Unkown
HY-116428 L-744832 / Unkown
HY-149705 ICMT-IN-7 Inhibitor / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-163515 Anticancer agent 207 Inhibitor / Unkown
HY-173632A AMG410 diTFA Inhibitor / Unkown
HY-175870A (7R)-Eras-4001 Inhibitor / Unkown
HY-176343S NRAS, U-15N / Unkown
HY-181284 BYBC-1 / Unkown
HY-181420 (S,R,S)-BBO-11818 / Unkown
HY-182411 KRAS-IN-56 Inhibitor / Unkown
HY-182504 NRA-0562 / Unkown
HY-183980 MJ-NR-27 Inhibitor / Unkown
HY-183981 RNA binder 4 / Unkown
HY-184437 NRAS-G4-ligand-1 Ligand / Unkown
HY-RS09558 NRAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09560 Nras Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1126467 RAS-IN-5 Inhibitor / Unkown
HY-101641 NRA-0160 Antagonist / Unkown
HY-110038 FTI-277 TFA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nras NCBI NCBI:4893