Eef2k - eukaryotic elongation factor-2 kinase Gene

Also Known as SMEF2K

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25435

Summary

Enables elongation factor-2 kinase activity. Involved in several processes, including cellular response to anoxia; positive regulation of cellular component organization; and response to peptide hormone. Located in dendritic spine and postsynaptic density. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Apr 2022]

Eef2k Products (1)

mRNA Protein Name
NM_012947.3 NP_037079.1 eukaryotic elongation factor 2 kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables elongation factor-2 kinase activity IMP
IMP: Inferred from mutant phenotype
8663182 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to anoxia IEP
IEP: Inferred from expression pattern
12194824 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
19625250 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9841860 RGD
involved in cellular response to calcium ion IEP
IEP: Inferred from expression pattern
19188248 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
9841860 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16227605 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
20427644 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
18045921 RGD
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
20427644 RGD
involved in regulation of translation at postsynapse IDA
IDA: Inferred from direct assay
20427644 RGD
involved in regulation of translation at postsynapse IEP
IEP: Inferred from expression pattern
20427644 RGD
involved in regulation of translation at postsynapse IMP
IMP: Inferred from mutant phenotype
20427644 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
12920134 RGD
involved in response to prolactin IEP
IEP: Inferred from expression pattern
8126003 RGD
Cellular Component GO Annotation Evidence References Source
located in dendritic spine IDA
IDA: Inferred from direct assay
12711090 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12711090 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
20427644 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
12711090 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic elongation factor 2 kinase

  • calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase

  • eEF-2 kinase

  • eEF-2K

  • elongation factor 2 kinase

  • eukaroytic elongation factor 2 kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110096 A-484954 Inhibitor 99.57% Unkown
HY-100576 NH125 Inhibitor 99.63% Unkown
HY-146324 PROTAC eEF2K degrader-1 Activator 98.64% Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-123024 Cefatrizine / Unkown
HY-176149 Fluoxetine-Conjugated Platinum(IV) prodrug-1 / Unkown
HY-177720 eEF2K degrader-2 / Unkown
HY-181506 TYMJ-01 / Unkown
HY-184950 eEF2K ligand-1 Ligand / Unkown
HY-RS04181 EEF2K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20013 Eef2k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26516 Eef2k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eef2k NCBI NCBI:29904