EEF2K - eukaryotic elongation factor 2 kinase Gene

Homo sapiens

Also known as eEF-2K; CaMKIII; HSU93850

Gene ID: 29904 | Gene type: protein coding

About EEF2K

Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:22,206,278-22,288,738 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 207 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 21.4), fat (RPKM 10.0) and 24 other tissues.

Summary

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008]

EEF2K Products(1)

mRNA	Protein	Name
NM_013302.5	NP_037434.2	eukaryotic elongation factor 2 kinase

EEF2K Protein Structure

Alpha_kinase

Sel1

0
200
400
600
725 a.a.

Protein Preferred Names

Protein Names

eukaryotic elongation factor 2 kinase

alternative protein EEF2K

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100576	NH125	Inhibitor	99.81%	Unkown
HY-110096	A-484954	Inhibitor	98.18%	Unkown
HY-121828	TX-1123	Inhibitor	/	Unkown
HY-123024	Cefatrizine		/	Unkown
HY-146324	PROTAC eEF2K degrader-1		/	Unkown
HY-RS04181	EEF2K Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EEF2K	VGNC	VGNC:72098
Felis catus	EEF2K	VGNC	VGNC:61734
Rattus norvegicus	EEF2K	RGD	RGD:2538
Mus musculus	EEF2K	MGD	MGI:1195261
Bos taurus	EEF2K	VGNC	VGNC:28336
Canis familiaris	EEF2K	VGNC	VGNC:40210
Others	EEF2K	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.