Parg - poly (ADP-ribose) glycohydrolase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26430

About Parg

Chromosome 14: 31,923,906-32,019,507 forward strand.GRCm39:CM001007.3

This gene has 10 transcripts (splice variants), 245 orthologues and is associated with 21 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 6.1), CNS E14 (RPKM 3.9) and 28 other tissues.

Summary

Enables poly(ADP-ribose) glycohydrolase activity. Acts upstream of or within cellular response to DNA damage stimulus and detection of bacterium. Located in cytosol and nucleus. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Orthologous to several human genes including BPHL (biphenyl hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]

Parg Products (3)

mRNA Protein Name
NM_001374221.1 NP_001361150.1 poly(ADP-ribose) glycohydrolase isoform 3
NM_011960.3 NP_036090.2 poly(ADP-ribose) glycohydrolase isoform 1
NM_001359915.1 NP_001346844.1 poly(ADP-ribose) glycohydrolase isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables poly(ADP-ribose) glycohydrolase activity IMP
IMP: Inferred from mutant phenotype
15282315 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
15282315 MGI
acts upstream of or within detection of bacterium IMP
IMP: Inferred from mutant phenotype
15282315 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IMP
IMP: Inferred from mutant phenotype
15282315 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15282315 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Parg Protein Structure

PARG_cat

PARG_cat: pfam05028 (573 - 898)

  • 0
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  • 961 a.a.
Protein Preferred Names Protein Names

poly(ADP-ribose) glycohydrolase

  • cytosolic poly(ADP-ribose) glycohydrolase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0889 Ethacridine lactate monohydrate Inhibitor 99.85% Unkown
HY-B2174 Ethacridine lactate Inhibitor 99.83% Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99965 Crovalimab Inhibitor 99.59% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-156881 PARG-IN-4 98.50% Phase 4
HY-164717 FORX-428 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108360 PDD 00017273 99.64% Unkown
HY-128760 COH34 99.97% Unkown
HY-146248B TFMU-ADPr diammonium 98.78% Unkown
HY-133531 PDD00017272 99.01% Unkown
HY-137924 JA2131 Inhibitor 99.7% Unkown
HY-133530 PDD00017238 98.71% Unkown
HY-178208 MDOLL-0286 Inhibitor 99.66% Unkown
HY-134354A pNP-ADPr disodium 98.08% Unkown
HY-122041 Ethacridine 98.60% Unkown
HY-135846 PDD00031705 99.47% Unkown
HY-115666 COH34 analog 1 98.75% Unkown
HY-146248A TFMU-ADPr triethylamine 97.26% Unkown
HY-134354 pNP-ADPr / Unkown
HY-146248 TFMU-ADPr / Unkown
HY-153574 BI01826025 Degrader / Unkown
HY-171789 PARG-IN-7 Inhibitor / Unkown
HY-177420 PDD00031704 Inhibitor / Unkown
HY-RS10040 PARG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10041 Parg Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10042 Parg Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parg NCBI NCBI:8505