Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

Also Known as HGK; Nik; 9430080K19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26921

About Map4k4

Chromosome 1: 39,940,073-40,065,470 forward strand.GRCm39:CM000994.3

This gene has 18 transcripts (splice variants), 281 orthologues, 35 paralogues and is associated with 6 phenotypes. Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map4k4 Products (4)

mRNA Protein Name
NM_001252201.1 NP_001239130.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3
NM_008696.2 NP_032722.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2
NM_001252200.1 NP_001239129.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
NM_001252202.1 NP_001239131.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9135144 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16938849 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9135144 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of ARF protein signal transduction IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
9135144 MGI
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of focal adhesion disassembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9135144 MGI
Cellular Component GO Annotation Evidence References Source
located in focal adhesion IDA
IDA: Inferred from direct assay
25490267 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map4k4 Protein Structure

PKc_like

PKc_like: cl21453 (7 - 288)

CNH

CNH: smart00036 (969 - 1267)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1288 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 4

  • HPK/GCK-like kinase HGK

  • MAPK/ERK kinase kinase kinase 4

  • MEK kinase kinase 4

  • MEKKK 4

  • NCK interacting kinase

  • nck-interacting kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160623 Rentosertib 99.96% Unkown
HY-100343 GNE-495 Inhibitor 99.49% Unkown
HY-19562 PF-06260933 Inhibitor 99.39% Unkown
HY-111754 DMX-5804 Inhibitor 99.83% Unkown
HY-168972 Famlasertib Inhibitor 99.94% Unkown
HY-125012 MAP4K4-IN-3 Inhibitor 99.77% Unkown
HY-156715 MASTL-IN-1 Inhibitor 99.54% Unkown
HY-132290 TGFβRI-IN-3 Inhibitor 98.21% Unkown
HY-W003471 Pyrrolo[2,1-f][1,2,4]triazin-4-amine Inhibitor / Unkown
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% Unkown
HY-137340 WH-10417-099 Degrader 98.14% Unkown
HY-156523 TNIK&MAP4K4-IN-1 99.73% Unkown
HY-19562A PF-06260933 hydrochloride Inhibitor 99.42% Unkown
HY-U00428 GNE 220 Inhibitor / Unkown
HY-123965 PF-06745013 Inhibitor / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-RS08080 MAP4K4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08081 Map4k4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08082 Map4k4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W207224 F1386-0303 Inhibitor / Unkown
HY-W402208 MAP4K4-IN-7 Inhibitor / Unkown
HY-178775 PI4K-IN-3 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k4 NCBI NCBI:9448