GPT - glutamic--pyruvic transaminase Gene
Also Known as ALT; AAT1; ALT1; GPT1; SGPT
Species: Homo sapiens
About GPT
This gene has 7 transcripts (splice variants), 260 orthologues and 7 paralogues. Biased expression in liver (RPKM 18.5), kidney (RPKM 12.6) and 12 other tissues.
Summary
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and Amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, Infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
GPT Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001382664.1 | NP_001369593.1 | alanine aminotransferase 1 |
| NM_001382665.1 | NP_001369594.1 | alanine aminotransferase 1 |
| NM_005309.3 | NP_005300.1 | alanine aminotransferase 1 |
GPT Protein Structure
Aminotran_1_2: Aminotransferase class I and II (86 - 483)
- 0
- 100
- 200
- 300
- 400
- 496 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
alanine aminotransferase 1 |
|
GPT Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P811265 | GPT Antibody | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hepatitis |
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| Liver Disease |
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| Viral Hepatitis |
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| Hepatitis C |
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| Biliary Atresia |
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| Hepatitis D |
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| Scrub Typhus |
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| Choledocholithiasis |
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| Autoimmune Hepatitis |
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| Hepatitis E |
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| Viral Infectious Disease |
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| Liver Cirrhosis |
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| Hepatitis B |
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| Cholecystitis |
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| Hepatic Encephalopathy |
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| Alcoholic Hepatitis |
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| Cholangitis |
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| Hemosiderosis |
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| Alcohol Use Disorder |
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| Kawasaki Disease |
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| Kwashiorkor |
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| Hepatic Tuberculosis |
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| Cholelithiasis |
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| Drug-Induced Hepatitis |
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| Portal Hypertension |
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| Fascioliasis |
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| Hellp Syndrome |
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| Acute Cholangitis |
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| Hepatitis A |
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| Hyperuricemia |
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| Ascending Cholangitis |
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| Bile Duct Cysts |
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| Obstructive Jaundice |
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| Cholestasis |
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| Granulomatous Hepatitis |
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| Non-Alcoholic Fatty Liver Disease |
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| Opisthorchiasis |
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| Alcoholic Liver Cirrhosis |
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| Canavan Disease |
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| Glucose Intolerance |
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| Common Bile Duct Disease |
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| Cholangitis, Primary Sclerosing |
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| Nasopharyngitis |
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| Acute Pancreatitis |
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| Polyarteritis Nodosa |
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| Alpha-1-Antitrypsin Deficiency |
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| Dipetalonemiasis |
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| Hepatic Vascular Disease |
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| Typhoid Fever |
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| Exanthem |
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| Protein-Energy Malnutrition |
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| Bilirubin Metabolic Disorder |
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| Neuroleptic Malignant Syndrome |
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| Esophageal Varix |
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| Phenobarbital Allergy |
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| Acalculous Cholecystitis |
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| Type 2 Diabetes Mellitus |
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| Wilson Disease |
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| Myoglobinuria |
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| Afferent Loop Syndrome |
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| Non-Alcoholic Steatohepatitis |
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| Acute Kidney Failure |
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| Intrahepatic Cholestasis |
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| Siderosis |
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| Fatty Liver Disease |
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| Pyelonephritis |
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| Disseminated Intravascular Coagulation |
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| Peliosis Hepatis |
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| Cryoglobulinemia |
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| Hepatic Infarction |
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| Lipid Storage Disease |
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| Vein Disease |
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| Hepatitis C Virus |
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| Pyuria |
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| Suppurative Cholangitis |
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| Hepatic Coma |
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| Schistosomiasis |
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| Trypanosomiasis |
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| Bile Duct Cancer |
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| Viral Laryngitis |
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| Metabolic Acidosis |
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| Neutropenia |
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| Sclerosing Cholangitis |
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| Nutmeg Liver |
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| Crimean-Congo Hemorrhagic Fever |
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| Diarrhea |
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| Sleep Apnea |
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| Cholecystolithiasis |
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| Epidemic Typhus |
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| Prediabetes Syndrome |
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| Emphysematous Cholecystitis |
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| Hyperthyroidism |
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| Coronary Aneurysm |
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| Heart Aneurysm |
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| Bile Duct Disease |
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| Splenic Abscess |
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| Calcinosis |
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| Pericardium Disease |
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| Primary Biliary Cholangitis |
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| Severe Acute Respiratory Syndrome |
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| Bile Duct Carcinoma In Situ |
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| Malignant Hyperthermia |
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| Arthritis |
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| Pellagra |
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| Biliary Tract Disease |
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| Non-Severe Covid-19 |
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| Rubella |
|
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| Pyridoxine Deficiency |
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| Cecal Disease |
|
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| Klatskin'S Tumor |
|
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| Leishmaniasis |
|
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| Portal Vein Thrombosis |
|
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| Thalassemia |
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| Pneumonia |
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| Pancreas Lymphoma |
|
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| Paralytic Ileus |
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| Immune Deficiency Disease |
|
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| Diabetes Mellitus |
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| Blood Coagulation Disease |
|
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| Hepatocellular Carcinoma |
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| Arteriosclerosis |
|
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| Body Mass Index Quantitative Trait Locus 11 |
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| Drug Allergy |
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| Analbuminemia |
|
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| Splenic Infarction |
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| Heterophyiasis |
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| Beta-Thalassemia |
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| Extrahepatic Cholestasis |
|
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| Otitis Media |
|
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| Intrahepatic Cholestasis Of Pregnancy |
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| Abdominal Tuberculosis |
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| Hepatorenal Syndrome |
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| Interleukin-7 Receptor Alpha Deficiency |
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| Thyroid Crisis |
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| Pancreatic Colloid Cystadenoma |
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| Substance Abuse |
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| Malaria |
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| Metal Metabolism Disorder |
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| Hypothyroidism |
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| Miliary Tuberculosis |
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| Reye Syndrome |
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| Tricuspid Valve Disease |
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| Pancreatic Cancer |
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| Autoimmune Disease Of Gastrointestinal Tract |
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| Plasma Protein Metabolism Disease |
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| Second-Degree Atrioventricular Block |
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| Duodenal Obstruction |
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| Aspiration Pneumonia |
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| Postcholecystectomy Syndrome |
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| Gilbert Syndrome |
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| Compartment Syndrome |
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| Gummatous Syphilis |
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| Endemic Typhus |
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| Hydrops Of Gallbladder |
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| Volvulus Of Midgut |
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| Gastrointestinal Tuberculosis |
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| Blood Platelet Disease |
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| Heart Disease |
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| Cecum Lymphoma |
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| Tricuspid Valve Insufficiency |
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| Dicrocoeliasis |
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| Hypersplenism |
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| Hemorrhoid |
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| Lipoprotein Quantitative Trait Locus |
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| Peripheral Neuropathy With Variable Spasticity, Exercise Intolerance, And Developmental Delay |
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| Urinary Tract Infection |
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| Myopathy |
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| Paronychia |
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| Pericardial Effusion |
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| Chronic Cholangitis |
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| Choline Deficiency Disease |
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| Viral Pneumonia |
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| Extrapulmonary Tuberculosis |
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| Lung Abscess |
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| Active Peptic Ulcer Disease |
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| Pericholangitis |
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| Mesenteric Lymphadenitis |
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| Biliary Dyskinesia |
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| Cataract 10, Multiple Types |
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| Splenic Disease |
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| Alcohol Dependence |
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| Rocky Mountain Spotted Fever |
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| Pulmonary Artery Disease |
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| Hair Disease |
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| Amelogenesis Imperfecta, Type If |
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| Intestinal Perforation |
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| Thrombocytopenia |
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| Peptic Ulcer Disease |
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| Klebsiella Pneumonia |
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| Amelogenesis Imperfecta, Type Ie |
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| Caroli Disease |
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| Babesiosis |
|
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| Lysosomal Storage Disease |
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| Acute Necrotizing Pancreatitis |
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| Leukocyte Disease |
|
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| Cellulitis |
|
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| Diabetes Mellitus, Ketosis-Prone |
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| Primary Bacterial Infectious Disease |
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| Secondary Syphilis |
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| Gallbladder Disease |
|
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| Pleural Empyema |
|
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| Lymph Node Disease |
|
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| Occlusion Of Gallbladder |
|
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| Coronavirus Infectious Disease |
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| Critical Covid-19 |
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| Tuberculous Encephalopathy |
|
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| Bacterial Pneumonia |
|
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| Protein-Losing Enteropathy |
|
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| Spontaneous Tension Pneumothorax |
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| Pneumocystosis |
|
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| Early Congenital Syphilis |
|
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| Dengue Hemorrhagic Fever |
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| Cardiac Tamponade |
|
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| Apnea, Obstructive Sleep |
|
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| Spotted Fever |
|
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| Ascaris Lumbricoides Infection |
|
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| Budd-Chiari Syndrome |
|
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| Hypertension, Essential |
|
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| Severe Cutaneous Adverse Reaction |
|
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| Syphilis |
|
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| Hemopneumothorax |
|
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| Conjunctival Disease |
|
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| Severe Covid-19 |
|
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| Pre-Eclampsia |
|
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| Bronchopneumonia |
|
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| Acute Kidney Tubular Necrosis |
|
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| Pharyngitis |
|
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| Dengue Shock Syndrome |
|
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| Hypercholesterolemia, Familial, 1 |
|
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| Dengue Disease |
|
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| Mineral Metabolism Disease |
|
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| Plasmodium Vivax Malaria |
|
|
| Intestinal Obstruction |
|
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| Severe Pre-Eclampsia |
|
|
| Mitral Valve Insufficiency |
|
|
| Ehrlichiosis |
|
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| Endocardium Disease |
|
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| Bacterial Conjunctivitis |
|
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| Hemorrhagic Disease |
|
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| Factor Xi Deficiency |
|
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| External Ear Disease |
|
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| Thyroid Gland Disease |
|
|
| Liver Leiomyosarcoma |
|
|
| Liver Benign Neoplasm |
|
|
| Ankylosing Spondylitis 1 |
|
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| Otitis Externa |
|
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| Mitral Valve Disease |
|
|
| Disease By Infectious Agent |
|
|
| Acquired Metabolic Disease |
|
|
| Septic Arthritis |
|
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| Inherited Metabolic Disorder |
|
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| Disseminated Chorioretinitis |
|
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| Substance Dependence |
|
|
| Hypokalemia |
|
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| Hemoglobin D Disease |
|
|
| Coccidiosis |
|
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| Integumentary System Disease |
|
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| Intrahepatic Bile Duct Adenoma |
|
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| Gallbladder Cancer |
|
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| Duodenum Adenoma |
|
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| Extrinsic Cardiomyopathy |
|
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| Chickenpox |
|
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| Carbohydrate Metabolic Disorder |
|
|
| Human Granulocytic Anaplasmosis |
|
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| Glucose Metabolism Disease |
|
|
| Myocardial Infarction |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Cataract |
|
|
| Glucosephosphate Dehydrogenase Deficiency |
|
|
| Hemophagocytic Lymphohistiocytosis |
|
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| Beta-Thalassemia Major |
|
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| Lipid Metabolism Disorder |
|
|
| Late Congenital Syphilis |
|
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| Overnutrition |
|
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| Rectal Disease |
|
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| Muscular Dystrophy |
|
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| Respiratory Failure |
|
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| Heart Conduction Disease |
|
|
| Hemochromatosis, Type 1 |
|
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| Constipation |
|
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| Necrotizing Gastritis |
|
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| Lipoma Of Colon |
|
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| Large Intestine Lipoma |
|
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| Pancytopenia |
|
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| Hemoglobinopathy |
|
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| Deficiency Anemia |
|
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| Patent Foramen Ovale |
|
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| Inguinal Hernia |
|
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| Retinitis Pigmentosa |
|
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| Skin Disease |
|
|
| Celiac Disease 1 |
|
|
| Peripheral Nervous System Disease |
|
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| Nervous System Disease |
|
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| Connective Tissue Disease |
|
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| Eye Disease |
|
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | GPT | RGD | RGD:621720 |
| Felis catus | GPT | VGNC | VGNC:67451 |
| Mus musculus | GPT | MGD | MGI:95802 |
| Canis familiaris | GPT | VGNC | VGNC:41460 |
| Macaca mulatta | GPT | VGNC | VGNC:73150 |
| Bos taurus | GPT | VGNC | VGNC:29616 |
| Others | GPT | NCBI |