S1pr1 - sphingosine-1-phosphate receptor 1 Gene

Also Known as Edg1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29733

About S1pr1

Primary_assembly 2: 203,621,587-203,629,681 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 199 orthologues, 18 paralogues and is associated with 11 phenotypes. Biased expression in Lung (RPKM 299.1), Spleen (RPKM 279.3) and 8 other tissues.

Summary

Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of GTPase activity. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be intrinsic component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

S1pr1 Products (1)

mRNA Protein Name
NM_017301.2 NP_058997.1 sphingosine 1-phosphate receptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
11557736 RGD
enables sphingolipid binding IDA
IDA: Inferred from direct assay
9765227 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11557736 RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9765227 RGD
involved in endothelial cell differentiation IEP
IEP: Inferred from expression pattern
7959012 RGD
involved in negative regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
11094076 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
7959012 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9765227 RGD
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
14711826 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
11557736 RGD
involved in positive regulation of positive chemotaxis IDA
IDA: Inferred from direct assay
11094076 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
11557736 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
14711826 RGD
involved in transmission of nerve impulse IEP
IEP: Inferred from expression pattern
7959012 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S1pr1 Protein Structure

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (46 - 322)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (47 - 73)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (80 - 105)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (117 - 147)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (158 - 178)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (198 - 227)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (249 - 279)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
Protein Preferred Names Protein Names

sphingosine 1-phosphate receptor 1

  • EDG1 (Edg1)

  • S1P receptor 1

  • S1P receptor Edg-1

  • S1P1

  • endothelial differentiation G-protein coupled receptor 1

  • endothelial differentiation sphingolipid G-protein-coupled receptor 1

  • sphingosine 1-phosphate receptor Edg-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12355 Siponimod Agonist 99.95% Yes
HY-12288 Ozanimod Agonist 99.98% Yes
HY-10569 Ponesimod Agonist 99.78% Yes
HY-12288A Ozanimod hydrochloride Modulator 98.10% Yes
HY-12355A Siponimod hemifumarate Agonist 99.85% Yes

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
HY-132847 Vibozilimod Agonist 99.52% Phase 2
HY-119245 Udifitimod Modulator / Phase 2
HY-115831 SAR247799 Agonist 99.38% Phase 1
HY-14976 CS-0777 Modulator / Phase 1

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008947 SEW​2871 Agonist 99.88% Unkown
HY-111253 CYM-5478 Agonist 99.90% Unkown
HY-136578 RP101988 Agonist 98.80% Unkown
HY-176533 S1PR5-IN-1 Inhibitor 99.58% Unkown
HY-158417 KSI-6666 Antagonist 96.15% Unkown
HY-136576 RP101075 Agonist 99.19% Unkown
HY-109038 Mocravimod Modulator 98.39% Yes
HY-147660 IMMH001 Agonist 98.10% Unkown
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist 98.0% Unkown
HY-14433 PF-462991 Agonist / Unkown
HY-120615 BMS-520 Agonist / Unkown
HY-136577 RP101442 Agonist / Unkown
HY-183578 TYY-31 Agonist / Unkown
HY-181875 S1PR1/S1PR5 agonist-1 Inhibitor / Unkown
HY-178491 S1PR1 agonist 3 Agonist / Unkown
HY-108492 TC-SP 14 Agonist / Unkown
HY-182626 CS1P1 Antagonist / Unkown
HY-14402 AMG 369 Agonist / Unkown
HY-182375 (R)-SLB1122168 free base Inhibitor / Unkown
HY-182960 KRP-203 monophosphate / Unkown
HY-18334 GSK-2262167 sodium Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens S1pr1 NCBI NCBI:1901