Brdt - bromodomain testis associated Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 305123

About Brdt

Restricted expression toward (RPKM 382.8).

Summary

Predicted to enable lysine-acetylated histone binding activity and nucleosomal histone binding activity. Involved in chromatin remodeling and spermatogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in azoospermia; oligospermia; and spermatogenic failure 21. Orthologous to human BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Apr 2022]

Brdt Products (2)

mRNA Protein Name
NM_001012031.3 NP_001012031.1 bromodomain testis-specific protein isoform 2
NM_001402393.1 NP_001389322.1 bromodomain testis-specific protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22215678 RGD
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
22215678 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
22215678 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brdt Protein Structure

Bromo_Brdt_I_like

Bromo_Brdt_I_like: cd05497 (25 - 131)

Bromodomain

Bromodomain: cl02556 (270 - 321)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

bromodomain testis-specific protein

  • bromodomain, testis-specific

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-13030 (+)-JQ-1 Inhibitor 99.91% Phase 1
HY-112090 ABBV-744 Inhibitor 99.97% Phase 1
HY-117286 (S)-JQ-35 Inhibitor 99.46% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136570 GSK778 Inhibitor 99.14% Unkown
HY-136571 GSK046 Inhibitor 99.70% Unkown
HY-138563 GSK973 Inhibitor 99.97% Unkown
HY-130622 LT052 Inhibitor 98.02% Unkown
HY-114504 RVX-297 Inhibitor 95.00% Unkown
HY-112610 CF53 Inhibitor 99.81% Unkown
HY-131061 BET bromodomain inhibitor 1 Inhibitor 99.67% Unkown
HY-160558 PLK1/BRD4-IN-3 Inhibitor 98.55% Unkown
HY-126325 BY27 Inhibitor / Unkown
HY-182371 BRD4 ligand 15 Ligand / Unkown
HY-150683 NC-III-49-1 Inhibitor / Unkown
HY-153573 SRG-II-19F Degrader / Unkown
HY-153574 BI01826025 Degrader / Unkown
HY-155680 BET BD2-IN-1 Inhibitor / Unkown
HY-183247 BRDT-IN-1 Inhibitor / Unkown
HY-152213 BET-IN-13 Inhibitor / Unkown
HY-150684 GXH-II-052 Inhibitor / Unkown
HY-183248 BRDT-IN-2 Inhibitor / Unkown
HY-143471 WNY0824 Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown
HY-136794 SB-284851-BT Inhibitor / Unkown
HY-136570A GSK778 hydrochloride Inhibitor / Unkown
HY-177140 CDD-1147 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brdt NCBI NCBI:676