HLA-A - major histocompatibility complex, class I, A Gene
Also Known as HLAA
Species: Homo sapiens
About HLA-A
This gene has 9 transcripts (splice variants), 1 gene allele, 564 orthologues, 22 paralogues and is associated with 85 phenotypes. Ubiquitous expression in colon (RPKM 288.9), lung (RPKM 280.7) and 25 other tissues.
Summary
HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria Parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]
HLA-A Products (6)
| mRNA | Protein | Name |
|---|---|---|
| NM_001242758.1 | NP_001229687.1 | HLA class I histocompatibility antigen, A alpha chain isoform A*01:01:01:01 precursor |
| NM_002116.8 | NP_002107.3 | HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor |
| NM_001242758.1 | NP_001229687.1 | HLA class I histocompatibility antigen, A alpha chain isoform A*01:01:01:01 precursor |
| NM_002116.8 | NP_002107.3 | HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor |
| NM_001242758.1 | NP_001229687.1 | HLA class I histocompatibility antigen, A alpha chain isoform A*01:01:01:01 precursor |
| NM_002116.8 | NP_002107.3 | HLA class I histocompatibility antigen, A alpha chain isoform A*03:01:01:01 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables CD8 receptor binding |
IDA
IDA: Inferred from direct assay
|
2784196 | GOA |
| enables T cell receptor binding |
IDA
IDA: Inferred from direct assay
|
8906788 | GOA |
| enables TAP binding |
IDA
IDA: Inferred from direct assay
|
8617941 | GOA |
| enables TAP complex binding |
IDA
IDA: Inferred from direct assay
|
8630735 | GOA |
| enables beta-2-microglobulin binding |
IDA
IDA: Inferred from direct assay
|
3309677 | GOA |
| enables beta-2-microglobulin binding |
IMP
IMP: Inferred from mutant phenotype
|
23566939 | GOA |
| enables peptide antigen binding |
IDA
IDA: Inferred from direct assay
|
1402688 | GOA |
| enables peptide antigen binding |
IMP
IMP: Inferred from mutant phenotype
|
23566939 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9177355 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
19124746 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in Golgi apparatus |
IDA
IDA: Inferred from direct assay
|
20946353 | GOA |
| located in Golgi medial cisterna |
IDA
IDA: Inferred from direct assay
|
8805302 | GOA |
| part of MHC class I peptide loading complex |
IDA
IDA: Inferred from direct assay
|
21263072 | GOA |
| part of MHC class I protein complex |
IDA
IDA: Inferred from direct assay
|
7694806 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
8805302 | GOA |
| located in endoplasmic reticulum |
IDA
IDA: Inferred from direct assay
|
8805302 | GOA |
| located in endoplasmic reticulum exit site |
IDA
IDA: Inferred from direct assay
|
20946353 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
2784196 | GOA |
HLA-A Protein Structure
MHC_I: pfam00129 (24 - 202)
IgC1_MHC_Ia_HLA-B: cd21026 (203 - 298)
IgC1_MHC_Ia_HLA-B: cd21026 (207 - 215)
IgC1_MHC_Ia_HLA-B: cd21026 (223 - 232)
IgC1_MHC_Ia_HLA-B: cd21026 (236 - 242)
IgC1_MHC_Ia_HLA-B: cd21026 (244 - 247)
IgC1_MHC_Ia_HLA-B: cd21026 (251 - 259)
IgC1_MHC_Ia_HLA-B: cd21026 (262 - 272)
IgC1_MHC_Ia_HLA-B: cd21026 (279 - 286)
IgC1_MHC_Ia_HLA-B: cd21026 (292 - 297)
MHC_I_C: pfam06623 (336 - 363)
- 0
- 100
- 200
- 300
- 365 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
HLA class I histocompatibility antigen, A alpha chain |
|
Recombinant HLA-A Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70391 | HLA-A*02:01&B2M&AFP(FMNKFIYEI) Monomer Protein, Human (HEK293, His) | P01892 (G25-I308)&P61769 (I21-M119)&FMNKFIYEI | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70392 | HLA-A*02:01&B2M&GP100(IMDQVPFSV) Monomer Protein, Human (HEK293, His) | P04439 (G25-I308, A269V)&P61769 (I21-M119)&IMDQVPFSV | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70393 | HLA-A*02:01&B2M&HPV16 E7(YMLDLQPET) Monomer Protein, Human (HEK293, His) | P01892 (G25-I308)&P61769 (I21-M119)&YMLDLQPET | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70394 | HLA-A*02:01&B2M&NY-ESO-1(SLLMWITQC) Monomer Protein, Human (HEK293, His) | P01892 (G25-I308, A269V)&P61769 (I21-M119)&SLLMWITQC | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P70395 | HLA-A*02:01&B2M&WT-1(RMFPNAPYL) Monomer Protein, Human (HEK293, His) | P01892 (G25-I308, A269V)&P61769 (I21-M119)&RMFPNAPYL | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72288 | HLA-A Protein, Human (His) | Q5SUL5 (G25-I308) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P72377 | HLA-A*02:01&B2M&GP100(IMDQVPFSV) Monomer Protein, Human (Biotinylated, HEK293, Avi-His) | P01892 (G25-I308, A269V)&P61769 (I21-M119)&IMDQVPFSV | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77781 | HLA-A*0301 KRAS G12V Complex Protein, Human (HEK293, His-Avi) | NP_002107.3 (G25-T305)&P61769 (I21-M119)&VVGAVGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77782 | HLA-A*03:01&B2M&KRAS G12V(VVGAVGVGK) Tetramer Protein, Human (HEK293, His-Avi) | NP_002107.3 (G25-T305)&P61769 (I21-M119)&VVGAVGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77783 | HLA-A*11:01&B2M&KRAS G12D(VVVGADGVGK) Protein, Human (HEK293, His-Avi) | AAV53343.1 (G25-T305)&P61769 (I21-M119)&VVVGADGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77784 | HLA-A*11:01&B2M&KRAS G12D(VVVGADGVGK) Monomer Protein, Human (Biotinylated, HEK293, His-Avi) | AAV53343.1 (G25-T305)&P61769 (I21-M119)&VVVGADGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77785 | HLA-A*11:01&B2M&KRAS G12D(VVVGADGVGK) Tetramer Protein, Human (HEK293, His-Avi) | AAV53343.1 (G25-T305)&P61769 (I21-M119)&VVVGADGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77786 | HLA-A*11:01&B2M&KRAS G12V(VVGAVGVGK) Monomer Protein, Human (HEK293, His-Avi) | AAV53343.1 (G25-T305)&P61769 (I21-M119)&VVGAVGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77787 | HLA-A*11:01&B2M&KRAS G12V(VVGAVGVGK) Monomer Protein, Human (Biotinylated, HEK293, His-Avi) | AAV53343.1 (G25-T305)&P61769 (I21-M119)&VVGAVGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77788 | HLA-A*11:01&B2M&KRAS G12V(VVGAVGVGK) Tetramer Protein, Human (HEK293, His-Avi) | AAV53343.1 (G25-T305)&P61769 (I21-M119)&VVGAVGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77790 | HLA-A*03:01&B2M&KRAS WT(VVVGAGGVGK) Protein, Human (Biotinylated, HEK293, His-Avi) | NP_002107.3 (G25-T305)&P61769 (I21-M119)&VVVGAGGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P77789 | HLA-A*03:01&B2M&KRAS WT(VVVGAGGVGK) Protein, Human (HEK293, His-Avi) | NP_002107.3 (G25-T305)&P61769 (I21-M119)&VVVGAGGVGK | ≥ 95%, as determined by Bis-Tris PAGE. |
HLA-A Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83195 | HLA Class 1 A Antibody (YA2940) | WB, IHC-P, ICC/IF, IP, FC | Human |
| HY-P83577 | MHC Class I Antibody (YA3322) | WB, IHC-P | Human |
| HY-P83577A | MHC Class I Antibody (YA3322)(PBS only) | WB, IHC-P | Human |
| HY-P84941 | HLA Class 1 ABC Antibody (YA4638) | ICC/IF, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Severe Cutaneous Adverse Reaction |
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| Birdshot Chorioretinopathy |
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| Severe Acute Respiratory Syndrome |
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| Uveitis |
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| Autoimmune Disease |
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| Pars Planitis |
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| Autoimmune Uveitis |
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| Malaria |
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| Pure Red-Cell Aplasia |
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| Cytomegalovirus Retinitis |
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| Herpes Zoster |
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| Chromoblastomycosis |
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| Covid-19 |
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| Multiple Sclerosis |
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| Human Herpesvirus 8 |
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| Familial Mediterranean Fever |
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| Histoplasmosis |
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| Pityriasis Rosea |
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| Takayasu Arteritis |
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| Rubella |
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| Graves' Disease |
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| Hemoglobinuria |
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| Porphyria Cutanea Tarda |
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| Cholangitis, Primary Sclerosing |
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| Optic Neuritis |
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| Hemorrhagic Cystitis |
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| Nasopharyngeal Carcinoma |
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| Tetanus |
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| Leptospirosis |
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| Echinococcosis |
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| Alopecia Areata |
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| Bare Lymphocyte Syndrome, Type Ii |
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| Diabetes Mellitus |
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| Juvenile Dermatitis Herpetiformis |
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| Chagas Disease |
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| Porphyria |
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| Autoimmune Hepatitis |
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| Behcet Syndrome |
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| Common Variable Immunodeficiency |
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| Celiac Disease 1 |
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| Cervical Cancer |
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| Immune Deficiency Disease |
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| Colorectal Cancer |
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| Type 1 Diabetes Mellitus |
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| Polyomavirus-Associated Nephropathy |
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| Caplan'S Syndrome |
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| Posterior Uveitis |
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| Viral Infectious Disease |
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| Psoriasis |
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| Melanoma |
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| Human Immunodeficiency Virus Infectious Disease |
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| Melanoma, Uveal |
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| Iritis |
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| Systemic Lupus Erythematosus |
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| Colorectal Cancer, Hereditary Nonpolyposis, Type 8 |
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| Ceftazidime Allergy |
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| Sarcoidosis 1 |
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| Lung Cancer |
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| Spondyloarthropathy |
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| Autosomal Dominant Intellectual Developmental Disorder 19 |
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| Mycobacterium Tuberculosis 1 |
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| Pfeiffer Syndrome |
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| Autoimmune Disease Of Endocrine System |
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| Abacavir Allergy |
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| Bare Lymphocyte Syndrome, Type I |
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| Leprosy 3 |
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| Autosomal Dominant Intellectual Developmental Disorder 40 |
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| Uveal Disease |
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| Heart Disease |
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| Gastric Cancer |
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| Hematologic Cancer |
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| Phenytoin Allergy |
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| Wilms Tumor 1 |
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| Renal Cell Carcinoma, Nonpapillary |
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| Hemochromatosis, Type 1 |
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| Lymphoma, Non-Hodgkin, Familial |
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| Aplastic Anemia |
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| Dystonia |
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| Myelodysplastic Syndrome |
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| Skin Disease |
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| Leukemia, Acute Myeloid |
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| Nervous System Disease |
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