CAPRIN1 - cell cycle associated protein 1 Gene

Also Known as M11S1; GPIAP1; RNG105; GPIP137; GRIP137; p137GPI

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 4076

About CAPRIN1

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:34,051,731-34,102,610 (from NCBI)

This gene has 17 transcripts (splice variants), 292 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 43.8), brain (RPKM 23.0) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in negative regulation of translation and positive regulation of dendritic spine morphogenesis. Located in cell leading edge and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CAPRIN1 Products (2)

mRNA Protein Name
NM_005898.5 NP_005889.3 caprin-1 isoform 1
NM_203364.3 NP_976240.1 caprin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables ATP binding IDA
IDA: Inferred from direct assay
34074792 GOA
enables mRNA binding IDA
IDA: Inferred from direct assay
17210633 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
31439799 GOA
enables molecular function activator activity IDA
IDA: Inferred from direct assay
32302570 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18005740 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
31439799 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
31439799 GOA
involved in non-membrane-bounded organelle assembly IDA
IDA: Inferred from direct assay
31439799 GOA
involved in positive regulation of stress granule assembly IDA
IDA: Inferred from direct assay
27022092 GOA
involved in regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
IDA: Inferred from direct assay
31439799 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cell leading edge IDA
IDA: Inferred from direct assay
28733330 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
28733330 GOA
is active in intracellular non-membrane-bounded organelle IDA
IDA: Inferred from direct assay
31439799 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPRIN1 Protein Structure

Caprin-1_C

Caprin-1_C: Cytoplasmic activation/proliferation-associated protein-1 C term (367 - 682)

  • 0
  • 200
  • 400
  • 600
  • 709 a.a.
Protein Preferred Names Protein Names

caprin-1

  • GPI-anchored membrane protein 1

CAPRIN1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CAPRIN1 Q14444 G3BP1 Homo sapiens Q13283
Fluorescence
18005740
Intra
CAPRIN1 Q14444 G3BP1 Homo sapiens Q13283
FPS
34799561
Cross: Cross-species interaction Intra: Intraspecies interaction

CAPRIN1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P89957 Caprin1 Antibody (YA9301) WB, ICC/IF, IF-Tissue, IP, ELISA human

関連疾患

Diseases Alias
Moyamoya Angiopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-162288 FAZ-3532 Inhibitor 99.66% Unkown
HY-162289 FAZ-3780 99.68% Unkown
HY-161110 APP degrader-1 Degrader 99.11% Unkown
HY-RS01897 CAPRIN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-165042 1,2-Dipalmitoyl-3-decanoyl-rac-glycerol / Unkown
HY-165105 1,3-Dioleoyl-2-decanoyl glycerol / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus CAPRIN1 VGNC VGNC:68117
Bos taurus CAPRIN1 VGNC VGNC:26751
Macaca mulatta CAPRIN1 VGNC VGNC:70692
Rattus norvegicus CAPRIN1 RGD RGD:1305707
Mus musculus CAPRIN1 MGD MGI:1858234
Canis familiaris CAPRIN1 VGNC VGNC:51857
Others CAPRIN1 NCBI