Il22 - interleukin 22 Gene

Also Known as IL-22; If2b1; Iltif; IL-22a; ILTIFa

Species: Mus musculus

Gene Type: protein coding
Gene ID: 50929

Summary

Predicted to enable cytokine activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; Reactive Oxygen Species metabolic process; and regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in retina and skin. Used to study liposarcoma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22). [provided by Alliance of Genome Resources, Apr 2022]

Il22 Products (1)

mRNA Protein Name
NM_016971.2 NP_058667.1 interleukin-22 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
28811323 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12700595 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
28811323 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23075849 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16982811 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16982811 MGI
acts upstream of or within reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
12700595 MGI
acts upstream of or within regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
12700595 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular space IDA
IDA: Inferred from direct assay
28811323 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-22

  • IL-10-related T-cell-derived-inducible factor

  • IL-TIF alpha

  • ILTIF alpha

  • interferon 2b1

  • interleukin 10-related T cell-derived inducible factor

  • interleukin-22a

Recombinant Il22 Proteins

Cat. No. Product Name Accession Purity
HY-P7079 IL-22 Protein, Mouse Q9JJY9 (L34-V179) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72793 IL-22 Protein, Mouse (CHO) Q9JJY9 (L34-V179) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78150 IL-22 Protein, Mouse (His-Avi) Q9JJY9 (L34-V179) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P7079A IL-22 Protein, Mouse (His) Q9JJY9 (L34-V179) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7079AF Animal-Free IL-22 Protein, Mouse (His) Q9JJY9 (L34-V179) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99244 Fezakinumab 99.9% Phase 2
HY-P99919 Efmarodocokin alfa Activator ≥99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147128 PY109 Agonist 99.15% Unkown
HY-133552 RORγt Inverse agonist 10 Antagonist 99.13% Unkown
HY-RS06737 IL22RA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162490 TF-S14 Inhibitor / Unkown
HY-168971 Paeoniflorin-6′-O-benzene sulfonate / Unkown
HY-182795 Colchicine derivative-1 / Unkown
HY-184385 PI3K/AKT/JAK2-IN-1 Inhibitor / Unkown
HY-RS06736 IL22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06738 IL22RA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174618 Human IL22RA2 mRNA / Unkown
HY-174619 Human IL22RA1 mRNA / Unkown
HY-174620 Human IL22 mRNA / Unkown
HY-RS16854 Il22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21241 Il22ra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23295 Il22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27758 Il22ra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990016 Temtokibart Inhibitor 99.23% Unkown
HY-P99917 Eflepedocokin alfa Activator ≥99.0% Unkown
HY-P990735 Donzakimig 98.67% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il22 NCBI NCBI:50616