PDC - phosducin Gene

Also Known as PHD; MEKA; PhLP; PhLOP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5132

About PDC

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,443,566-186,461,114 (from NCBI)

This gene has 2 transcripts (splice variants), 269 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a phosphoprotein, which is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PDC Products (2)

mRNA Protein Name
NM_002597.5 NP_002588.3 phosducin isoform a
NM_022576.4 NP_072098.1 phosducin isoform b

PDC Protein Structure

Phosducin

Phosducin: Phosducin (1 - 244)

  • 0
  • 100
  • 200
  • 246 a.a.
Protein Preferred Names Protein Names

phosducin

  • 33 kDa phototransducing protein

Related Diseases

Diseases Alias
Pollen Allergy

  • Hay Fever
Tomato Allergy

  • Solanum Lycopersicum Fruit Allergy
Timothy Grass Allergy
Melon Allergy

  • Cucumis Melo Fruit Allergy
Orange Allergy

  • Citrus Sinensis Fruit Allergy
Apple Allergy

  • Malus Domestica Fruit Allergy
Thunderstorm Triggered Asthma

  • Thunderstorm Asthma

  • Thunderstorm Related Asthma
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Peach Allergy

  • Prunus Persica Fruit Allergy
Fish Allergy

  • Allergy To Fish
Splenic Flexure Cancer

  • Ca Splenic Flexure - Colon

  • Malignant Neoplasm Of Splenic Flexure

  • Malignant Tumor Of Splenic Flexure

  • Malignant Neoplasm Of Splenic Flexure Of Colon
Usher Syndrome

  • Deafness-Retinitis Pigmentosa Syndrome

  • Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

  • Graefe-Usher Syndrome

  • Hallgren Syndrome

  • Usher'S Syndrome

  • Retinitis Pigmentosa-Deafness Syndrome

  • Retinitis Pigmentosa-Hearing Loss Syndrome

  • Ush

  • Usher Syndromes
Fruit Allergy

  • Allergy To Fruit
Legume Allergy

  • Fabaceae Allergy
Respiratory Allergy

  • Airway Allergy
Nasal Cavity Disease

  • Disorder Of Nasal Cavity
Nose Disease

  • Nose Diseases

  • Disorder Of The Nose

  • Nasal Disorder

  • Abnormality Of The Nose
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99168 Anifrolumab 99.79% Unkown

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-Y0445A Sodium dichloroacetate 99.78% Phase 3
HY-148511A Vidutolimod sodium Inhibitor 90.30% Phase 3
HY-139567 Afimetoran 99.37% Phase 2
HY-P2796 Pyruvate decarboxylase / Phase 2
HY-106195 L 377202 Ligand / Phase 2
HY-P4160 PDC31 Inhibitor 98.67% Phase 1
HY-P10762 Ricorfotide vedotin Ligand 98.45% Phase 1
HY-P10740 CBP-1018 Ligand 99.21% Phase 1
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99300 Ligelizumab Inhibitor 99.85% Phase 3
HY-P99226 Daxdilimab Inhibitor 97.82% Phase 2

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12836A IFN alpha-IFNAR-IN-1 hydrochloride Inhibitor 99.76% Unkown
HY-132296 GSK215 Inhibitor 99.26% Unkown
HY-P11072 IRF5-CPP5 Inhibitor 99.23% Unkown
HY-150217 CpG ODN 10101 Agonist 99.44% Unkown
HY-160719 2-octynoic acid-BSA / Unkown
HY-160231 ssRNA42 sodium Activator 98.62% Unkown
HY-P10741 DOTA-EB-TATE Activator 95.42% Unkown
HY-138794B XL177B 99.36% Unkown
HY-12836 IFN alpha-IFNAR-IN-1 Inhibitor 98.43% Unkown
HY-128606 Thiamine diphosphate analog 1 Activator / Unkown
HY-178489 BGC1614 / Unkown
HY-179166 PROTAC sEH degrader-4 Degrader / Unkown
HY-183717 M4K3233 / Unkown
HY-183718 M4K3250 Degrader / Unkown
HY-184389 PROTAC HDAC6 degrader 10 Degrader / Unkown
HY-188016 MC-GGFG-TriPtolide / Unkown
HY-P1094 AZ-10417808 Inhibitor / Unkown
HY-P11018 (123B9)2-L2-PTX Agonist / Unkown
HY-RS10184 PDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10777 PNKD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-170838 PDHK1-IN-1 Inhibitor / Unkown
HY-182173 pdC-CE phosphoramidite / Unkown
HY-RS17399 Pdc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23854 Pdc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W800833 Benzyl N-[2-(prop-2-enamido)ethyl]carbamate / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990276 Anti-Mouse CD317/BST2 Antibody (927) Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDC VGNC VGNC:106467
Canis familiaris PDC VGNC VGNC:44333
Mus musculus PDC MGD MGI:98090
Bos taurus PDC VGNC VGNC:32656
Rattus norvegicus PDC RGD RGD:3277
Others PDC NCBI