TIPIN - TIMELESS interacting protein Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54962

About TIPIN

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,336,191-66,386,717 (from NCBI)

This gene has 6 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 3.8), lymph node (RPKM 1.8) and 24 other tissues.

Summary

The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

TIPIN Products (9)

mRNA Protein Name
NM_001289986.2 NP_001276915.1 TIMELESS-interacting protein isoform 2
NM_001398281.1 NP_001385210.1 TIMELESS-interacting protein isoform 1
NM_001398282.1 NP_001385211.1 TIMELESS-interacting protein isoform 1
NM_001398283.1 NP_001385212.1 TIMELESS-interacting protein isoform 1
NM_001398284.1 NP_001385213.1 TIMELESS-interacting protein isoform 1
NM_001398285.1 NP_001385214.1 TIMELESS-interacting protein isoform 2
NM_001398286.1 NP_001385215.1 TIMELESS-interacting protein isoform 2
NM_001398287.1 NP_001385216.1 TIMELESS-interacting protein isoform 2
NM_017858.3 NP_060328.3 TIMELESS-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17102137 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA replication checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17102137 GOA
involved in cell cycle phase transition IMP
IMP: Inferred from mutant phenotype
17102137 GOA
involved in mitotic intra-S DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17102137 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17102137 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
17102137 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17102137 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TIPIN Protein Structure

Swi3

Swi3: Replication Fork Protection Component Swi3 (66 - 147)

  • 0
  • 100
  • 200
  • 301 a.a.
Protein Preferred Names Protein Names

TIMELESS-interacting protein

  • CSM3 homolog

TIPIN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TIPIN Q9BVW5 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
Intra
TIPIN Q9BVW5 GSC2 Homo sapiens O15499
Y2H Array
32296183
Intra
TIPIN Q9BVW5 TIMELESS Homo sapiens Q9UNS1
Chromatography
32705708
Intra
TIPIN Q9BVW5 TIMELESS Homo sapiens Q9UNS1
Anti Bait CoIP
17116885
Intra
TIPIN Q9BVW5 TIMELESS Homo sapiens Q9UNS1
Anti Tag CoIP
33961781
Intra
TIPIN Q9BVW5 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
TIPIN Q9BVW5 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
TIPIN Q9BVW5 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
TIPIN Q9BVW5 RPA2 Homo sapiens P15927
ITC
24910198
Intra
TIPIN Q9BVW5 RPA2 Homo sapiens P15927
NMR
24910198
Intra
TIPIN Q9BVW5 TEX11 Homo sapiens Q8IYF3
Validated Y2H
25416956
Intra
TIPIN Q9BVW5 TEX11 Homo sapiens Q8IYF3
Y2H Prey Pooling
25416956
Intra
TIPIN Q9BVW5 TEX11 Homo sapiens Q8IYF3
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14549 TIPIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TIPIN VGNC VGNC:47382
Mus musculus TIPIN MGD MGI:1921571
Macaca mulatta TIPIN VGNC VGNC:79873
Bos taurus TIPIN VGNC VGNC:35877
Rattus norvegicus TIPIN RGD RGD:1564084
Felis catus TIPIN VGNC VGNC:80821
Others TIPIN NCBI