Cd14 - CD14 molecule Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60350

Summary

Predicted to enable Lipopeptide binding activity; lipopolysaccharide binding activity; and lipoteichoic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; response to magnesium ion; and response to tumor necrosis factor. Located in cell surface; extracellular space; and plasma membrane. Used to study perinatal necrotizing enterocolitis. Biomarker of Hirschsprung's disease; cholestasis; obstructive jaundice; and periodontitis. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); celiac disease; cystic fibrosis; and pulmonary tuberculosis. Orthologous to human CD14 (CD14 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd14 Products (1)

mRNA Protein Name
NM_021744.1 NP_068512.1 monocyte differentiation antigen CD14 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18787027 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
22511970 RGD
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
12046090 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
19464360 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
10414605 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
16631199 RGD
involved in response to magnesium ion IEP
IEP: Inferred from expression pattern
16180088 RGD
involved in response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
10777809 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12046090 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12835948 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

monocyte differentiation antigen CD14

  • CD14 antigen

  • myeloid cell-specific leucine-rich glycoprotein

Recombinant Cd14 Proteins

Cat. No. Product Name Accession Purity
HY-P74331 CD14 Protein, Rat (HEK293, His) Q63691 (S18-Y341) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74332 CD14 Protein, Rat (HEK293, Fc) Q63691 (M1-Y341) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-N9965 2'-Fucosyllactose Inhibitor 99.97% Phase 2
HY-101132 VB-201 / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99008 Atibuclimab Inhibitor ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W251428 Phosphatidylglycerols (egg) sodium salt 99.53% Unkown
HY-135750 VAF347 Agonist 99.75% Unkown
HY-W040255 1-Palmitoyl-2-glutaryl-sn-glycero-3-phosphocholine 99.9% Unkown
HY-182019 HDAC11-IN-5 98.25% Unkown
HY-161901 BC-1293 Inhibitor 98.40% Unkown
HY-178049A UM-259 hydrochloride Inhibitor / Unkown
HY-101132A (Rac)-VB-201 Inhibitor / Unkown
HY-129684 IAXO-101 iodide Inhibitor / Unkown
HY-151399 Antimicrobial agent-5 Inhibitor / Unkown
HY-169067 10-Methoxy-canthin-6-one 98.71% Unkown
HY-D3334 PE-CF594 / Unkown
HY-RS02189 CD14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09127 NDUFA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16726 Cd14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23162 Cd14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991004 Itanistomig 95.84% Unkown
HY-P992435 OX118 Inhibitor / Unkown
HY-P991845 Anti-CD14 Antibody (UCHM-1) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd14 NCBI NCBI:929