SELPLG - selectin P ligand Gene

Homo sapiens

Also known as CLA; CD162; PSGL1; PSGL-1

Gene ID: 6404 | Gene type: protein coding

About SELPLG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,621,895-108,633,894 (from NCBI)

This gene has 3 transcripts (splice variants) and 72 orthologues. Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues.

Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- Selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

SELPLG Products(2)

mRNA	Protein	Name
NM_001206609.2	NP_001193538.1	P-selectin glycoprotein ligand 1 isoform 1 precursor
NM_003006.4	NP_002997.2	P-selectin glycoprotein ligand 1 isoform 2 precursor

Protein Preferred Names

Protein Names

P-selectin glycoprotein ligand 1

cutaneous lymphocyte-associated associated antigen

Recombinant SELPLG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72485	CD162/PSGL-1 Protein, Human (254a.a, HEK293, Fc)	Q14242 (Q42-G295)	≥95%
HY-P77162	CD162/PSGL-1 Protein, Human (HEK293, His-Fc)	AAC50061.1(L18-V295)	≥95%
HY-P77163	CD162/PSGL-1 Protein, Human (HEK293, His)	Q14242 (M1-G295)	≥95%
HY-P77164	CD162/PSGL-1 Protein, Human (HEK293, Fc)	AAC50061.1(L18-V295)	≥95%
HY-P78819	CD162/PSGL-1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q14242 (Q42-C320)	≥95%

Related Diseases

Diseases

Alias

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

Ehrlichiosis

Human Ehrlichiosis	He
Hey

Thrombosis

Thrombosis Of Blood Vessel

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Endocervicitis

Leukocyte Adhesion Deficiency, Type I

Leukocyte Adhesion Deficiency	Leukocyte Adhesion Deficiency 1
LAD1	Lad
Lymphocyte Function-Associated Antigen 1 Immunodeficiency	Leukocyte Adhesion Deficiency Type I
Leukocyte Adhesion Deficiency Type 1	Linear Iga Bullous Dermatosis
Linear Iga Dermatosis	Leukocyte-Adhesion Deficiency Syndrome
Lfa1 Immunodeficiency	Congenital Leukocyte Adherence Deficiency
Lad-I	Linear Iga Disease
Leukocyte Adhesion Deficiency Syndrome	Lad 1
Lfa 1 Immunodeficiency	Linear Immunoglobulin A Dermatosis
Leucocyte Adhesion Deficiency Type 1	Leukocyte Adhesion Molecule Deficiency Type 1

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon	Stage 0 Colonic Carcinoma
Stage 0 Carcinoma Of Colon	Intraepithelial Neoplasia Of Colon, High Grade
Carcinoma In Situ Of Cecum	Carcinoma In Situ Of Hepatic Flexure
Carcinoma In Situ Of Ileocecal Valve	Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ

Acute Flaccid Myelitis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Aseptic Meningitis

Acute Aseptic Meningitis	Meningitis Aseptic
Meningitis, Aseptic

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12648	SELPLG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELPLG	VGNC	VGNC:107723
Macaca mulatta	SELPLG	VGNC	VGNC:77158
Rattus norvegicus	SELPLG	RGD	RGD:1307971
Mus musculus	SELPLG	MGD	MGI:106689
Canis familiaris	SELPLG	VGNC	VGNC:45986
Bos taurus	SELPLG	VGNC	VGNC:34425
Macaca fascicularis	SELPLG	NCBI
Others	SELPLG	NCBI

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