SELPLG - selectin P ligand Gene

Also Known as CLA; CD162; PSGL1; PSGL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6404

About SELPLG

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:108,621,895-108,633,894 (from NCBI)

This gene has 3 transcripts (splice variants) and 72 orthologues. Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues.

Summary

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- Selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

SELPLG Products (2)

mRNA	Protein	Name
NM_001206609.2	NP_001193538.1	P-selectin glycoprotein ligand 1 isoform 1 precursor
NM_003006.4	NP_002997.2	P-selectin glycoprotein ligand 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11081633	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to interleukin-6	IDA IDA: Inferred from direct assay	9486531	GOA
involved in leukocyte migration	IDA IDA: Inferred from direct assay	25425738	GOA
involved in leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	25425738	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	21696602	GOA
located in plasma membrane raft	IDA IDA: Inferred from direct assay	25425738	GOA
located in uropod	IDA IDA: Inferred from direct assay	21696602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
P-selectin glycoprotein ligand 1	cutaneous lymphocyte-associated associated antigen

SELPLG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SELPLG	Q14242	SELP	Homo sapiens	P16109	SPR	19118202
Intra	SELPLG	Q14242	SNX20	Homo sapiens	Q7Z614	Peptide Array	18196517
Intra	SELPLG	Q14242	SNX20	Homo sapiens	Q7Z614	Y2H	18196517
Intra	SELPLG	Q14242	SNX20	Homo sapiens	Q7Z614	Anti Bait CoIP	18196517

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SELPLG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72485	CD162/PSGL-1 Protein, Human (HEK293, hFc)	Q14242-1 (Q42-G295)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77162	CD162/PSGL-1 Protein, Human (HEK293, His-Fc)	AAC50061.1 (L18-V295)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77163	CD162/PSGL-1 Protein, Human (HEK293, His)	Q14242-1 (L18-G295)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77164	CD162/PSGL-1 Protein, Human (HEK293, mFc)	AAC50061.1 (L18-V295)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78819	CD162/PSGL-1 Protein, Human (Biotinylated, HEK293, His-Avi)	Q14242-1 (Q42-C320)	≥ 90%, as determined by reducing SDS-PAGE.

SELPLG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81711	CD162 Antibody (YA1456)	WB, IHC-P, ICC/IF, IP	Human
HY-P84565	CD162 Antibody (YA4262)	IHC-P, FC, ELISA	Human
HY-P84565A	CD162 Antibody (YA4262)(PBS only)	IHC-P, FC, ELISA	Human
HY-P84970	CD162 Antibody (YA4662)	ELISA	Human

Related Diseases

Diseases	Alias
Human Granulocytic Anaplasmosis	Human Granulocytic Ehrlichiosis Hge Human Ehrlichial Infection, Human Granulocytic Type Human Anaplasmosis Due To Anaplasma Phagocytophilum
Ehrlichiosis	Human Ehrlichiosis He Hey
Thrombosis	Thrombosis Of Blood Vessel
Cerebrovascular Disease	Cerebrovascular Disorder Cerebrovascular Accident Cerebrovascular Disorders Cva Stroke
Endocervicitis
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Colon Carcinoma In Situ	Carcinoma In Situ Of Colon Stage 0 Colonic Carcinoma Stage 0 Carcinoma Of Colon Intraepithelial Neoplasia Of Colon, High Grade Carcinoma In Situ Of Cecum Carcinoma In Situ Of Hepatic Flexure Carcinoma In Situ Of Ileocecal Valve Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Acute Flaccid Myelitis
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Aseptic Meningitis	Acute Aseptic Meningitis Meningitis Aseptic Meningitis, Aseptic
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12648	SELPLG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18203	Selplg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24679	Selplg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELPLG	VGNC	VGNC:107723
Macaca mulatta	SELPLG	VGNC	VGNC:77158
Rattus norvegicus	SELPLG	RGD	RGD:1307971
Mus musculus	SELPLG	MGD	MGI:106689
Canis familiaris	SELPLG	VGNC	VGNC:45986
Bos taurus	SELPLG	VGNC	VGNC:34425
Others	SELPLG	NCBI