BNIP3L - BCL2 interacting protein 3 like Gene

Homo sapiens

Also known as NIX; BNIP3a

Gene ID: 665 | Gene type: protein coding

About BNIP3L

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:26,383,054-26,413,127 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 69.4), ovary (RPKM 49.9) and 24 other tissues.

Summary

This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 Family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

BNIP3L Products(2)

mRNA	Protein	Name
NM_001330491.2	NP_001317420.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 2
NM_004331.3	NP_004322.1	BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform 1

BNIP3L Protein Structure

BNIP3

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A

Recombinant BNIP3L Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75471	BNIP3L Protein, Human	NP_004322.1 (S2-K187)	≥95%

Related Diseases

Diseases

Alias

Pediculus Humanus Capitis Infestation

Pediculosis Capitis	Pediculus Capitis Infestation
Head Louse Infestation	Pediculus Capitis
Head-Louse Infestation	Head Lice
Infestation By Pediculus Capitis

Lice Infestation

Pediculosis	Louse Infestation
Mixed Pediculosis	Lice Infestations
Infestation By Pediculus	Mixed Pediculosis Infestation
Pediculosis + Lice	Pediculosis And Phthirus Infection
Pediculosis And Phthirus Infections	Pediculosis And Phthirus Infestation
Infestation By Anoplura	Pediculus Infestation
Lice Nos

Asbestos-Related Lung Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01565	BNIP3L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BNIP3L	MGD	MGI:1332659
Rattus norvegicus	BNIP3L	RGD	RGD:621354
Bos taurus	BNIP3L	VGNC	VGNC:26534
Macaca mulatta	BNIP3L	VGNC	VGNC:70274
Felis catus	BNIP3L	VGNC	VGNC:78457
Others	BNIP3L	NCBI

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