2. Gene
  3. Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Tyro10

Gene ID: 685781 | Gene type: protein coding

About Ddr2

Primary_assembly 13: 82,195,463-82,317,363 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 263 orthologues, 54 paralogues and is associated with 32 phenotypes. Biased expression in Uterus (RPKM 164.7), Heart (RPKM 14.2) and 8 other tissues.

Summary

Enables collagen binding activity. Involved in several processes, including negative regulation of cell death; positive regulation of cell population proliferation; and positive regulation of collagen biosynthetic process. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddr2 Products(1)

mRNA Protein Name
NM_031764.3 NP_113952.2 discoidin domain-containing receptor 2 precursor

Ddr2 Protein Structure

FA58C

FA58C: cd00057 (31 - 183)

PKc_like

PKc_like: cl21453 (556 - 849)

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  • 854 a.a.
Protein Preferred Names Protein Names

discoidin domain-containing receptor 2

CD167b antigen

discoidin domain receptor family, member 2

neurotrophic tyrosine kinase, receptor-related 3

receptor protein-tyrosine kinase TKT

tyrosine-protein kinase TYRO 10

Recombinant Ddr2 Proteins

Cat. No. Product Name Accession Purity
HY-P75297 DDR2 Protein, Rat (HEK293, His) B1WC09 (Q24-R399) ≥95%
HY-P75298 DDR2 Protein, Rat (HEK293, hFc) B1WC09 (M1-R399) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16961 Sitravatinib Inhibitor 99.59% Phase 3
HY-16961A Sitravatinib malate Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114169 WRG-28 Inhibitor 99.34% Unkown
HY-135401 VU6015929 Inhibitor 99.26% Unkown
HY-114311 FGFR1/DDR2 inhibitor 1 Inhibitor 98.26% Unkown
HY-114173 DDR1-IN-4 Inhibitor 98.01% Unkown
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-156552 DDR1/2 inhibitor-2 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddr2 NCBI NCBI:4921
Mus musculus Ddr2 NCBI NCBI:18214
Macaca mulatta Ddr2 NCBI NCBI:720124