Ddr2 - discoidin domain receptor tyrosine kinase 2 Gene

Also Known as Tyro10

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 685781

About Ddr2

Primary_assembly 13: 82,195,463-82,317,363 reverse strand.mRatBN7.2:CM026986.1

This gene has 2 transcripts (splice variants), 263 orthologues, 54 paralogues and is associated with 32 phenotypes. Biased expression in Uterus (RPKM 164.7), Heart (RPKM 14.2) and 8 other tissues.

Summary

Enables Collagen binding activity. Involved in several processes, including negative regulation of cell death; positive regulation of cell population proliferation; and positive regulation of Collagen biosynthetic process. Located in apical plasma membrane. Used to study alcoholic liver cirrhosis. Biomarker of alcoholic liver cirrhosis. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); osteoarthritis; and spondylometaepiphyseal dysplasia, short limb-hand type. Orthologous to human DDR2 (Discoidin Domain Receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ddr2 Products (1)

mRNA Protein Name
NM_031764.3 NP_113952.2 discoidin domain-containing receptor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
12220173 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
26674152 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
18664364 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
16087782 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
23409069 RGD
involved in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
IMP: Inferred from mutant phenotype
32412792 RGD
involved in negative regulation of kinase activity IMP
IMP: Inferred from mutant phenotype
19762078 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
26674152 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
32412792 RGD
involved in positive regulation of collagen biosynthetic process IDA
IDA: Inferred from direct assay
24938620 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
26674152 RGD
involved in positive regulation of hepatic stellate cell activation IMP
IMP: Inferred from mutant phenotype
23409069 RGD
involved in positive regulation of hepatic stellate cell proliferation IMP
IMP: Inferred from mutant phenotype
23409069 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
18664364 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16087782 RGD
involved in positive regulation of wound healing IMP
IMP: Inferred from mutant phenotype
26674152 RGD
involved in response to muscle stretch IEP
IEP: Inferred from expression pattern
16087782 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15218324 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ddr2 Protein Structure

FA58C

FA58C: cd00057 (31 - 183)

PKc_like

PKc_like: cl21453 (556 - 849)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 854 a.a.
Protein Preferred Names Protein Names

discoidin domain-containing receptor 2

  • CD167b antigen

  • discoidin domain receptor family, member 2

  • neurotrophic tyrosine kinase, receptor-related 3

  • receptor protein-tyrosine kinase TKT

  • tyrosine-protein kinase TYRO 10

Recombinant Ddr2 Proteins

Cat. No. Product Name Accession Purity
HY-P75297 DDR2 Protein, Rat (HEK293, His) B1WC09 (Q106-V400) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75298 DDR2 Protein, Rat (HEK293, hFc) B1WC09 (Q106-R481) ≥ 80%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16961 Sitravatinib Inhibitor 99.57% Phase 3

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114169 WRG-28 Inhibitor 99.76% Unkown
HY-135401 VU6015929 Inhibitor 99.50% Unkown
HY-114173 DDR1-IN-4 Inhibitor 98.19% Unkown
HY-NP175 Collagen (bovine skin) Ligand / Unkown
HY-114311 FGFR1/DDR2 inhibitor 1 Inhibitor 98.26% Unkown
HY-156552 DDR1/2 inhibitor-2 Inhibitor 99.73% Unkown
HY-13979A DDR1-IN-1 dihydrochloride Inhibitor 98.92% Unkown
HY-167208 SR-302 Inhibitor 98.51% Unkown
HY-175202 CIDD-8633 Inhibitor / Unkown
HY-16961A Sitravatinib malate Inhibitor / Unkown
HY-176849 DDR2-IN-2 Inhibitor / Unkown
HY-14979A ML786 dihydrochloride Inhibitor / Unkown
HY-181839 DDR1/2 IN-4 Inhibitor / Unkown
HY-162102 DDR1-IN-8 Inhibitor / Unkown
HY-122848 DDR1/2 inhibitor-3 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992066 Anti-Mouse DDR2 Antibody (DAB0065) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ddr2 NCBI NCBI:4921