Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

Also Known as ERIS; MPYS; Mita; STING; Tmem173; STING-beta; 2610307O08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72512

About Sting1

Chromosome 18: 35,866,732-35,873,607 reverse strand.GRCm39:CM001011.3

This gene has 10 transcripts (splice variants), 184 orthologues and is associated with 35 phenotypes. Broad expression in spleen adult (RPKM 3.3), mammary gland adult (RPKM 29.1) and 2 other tissues.

Summary

Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein Ligase binding activity. Involved in several processes, including defense response to Other organism; macroautophagy; and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including autophagosome; perinuclear region of cytoplasm; and peroxisome. Is expressed in ductus deferens; epididymis; ileum; and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sting1 Products (3)

mRNA Protein Name
NM_028261.1 NP_082537.1 stimulator of interferon genes protein isoform 1
NM_001289592.1 NP_001276521.1 stimulator of interferon genes protein isoform 3
NM_001289591.1 NP_001276520.1 stimulator of interferon genes protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 2',3'-cyclic GMP-AMP binding IDA
IDA: Inferred from direct assay
23258412 MGI
enables cyclic-di-GMP binding IDA
IDA: Inferred from direct assay
21947006 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21892174 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
21074459 MGI
Biological Process GO Annotation Evidence References Source
involved in activation of innate immune response IDA
IDA: Inferred from direct assay
23910378 MGI
involved in activation of innate immune response IMP
IMP: Inferred from mutant phenotype
21947006 MGI
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
30568238 MGI
involved in cGAS/STING signaling pathway IDA
IDA: Inferred from direct assay
37832545 MGI
acts upstream of or within cellular response to interferon-beta IMP
IMP: Inferred from mutant phenotype
21892174 MGI
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
26669264 MGI
acts upstream of or within defense response to virus IMP
IMP: Inferred from mutant phenotype
21892174 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
19776740 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
23910378 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
19433799 MGI
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19433799 MGI
involved in positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
30568238 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21892174 MGI
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
26669264 MGI
involved in positive regulation of type I interferon-mediated signaling pathway IDA
IDA: Inferred from direct assay
23910378 MGI
acts upstream of or within regulation of cellular metabolic process IGI
IGI: Inferred from genetic interaction
28069950 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23160154 MGI
acts upstream of or within regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
28069950 MGI
involved in reticulophagy IDA
IDA: Inferred from direct assay
29056340 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
19926846 MGI
located in Golgi membrane IDA
IDA: Inferred from direct assay
27324217 MGI
part of STING complex IPI
IPI: Inferred from physical interaction
23910378 MGI
located in autophagosome IDA
IDA: Inferred from direct assay
29056340 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24560620 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19926846 MGI
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
37832545 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
19776740 MGI
is active in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: Inferred from direct assay
37832545 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19776740 MGI
located in peroxisome IDA
IDA: Inferred from direct assay
22745163 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sting1 Protein Structure

TMEM173

TMEM173: pfam15009 (43 - 335)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

stimulator of interferon genes protein

  • endoplasmic reticulum interferon stimulator

  • mediator of IRF3 activation

  • mitochondrial mediator of IRF3 activation

  • stimulator of interferon protein

  • transmembrane protein 173

Sting1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Sting1 Q3TBT3 Ddx41 Mus musculus Q91VN6
Anti Bait CoIP
23142775
Intra
Sting1 Q3TBT3 Ddx41 Mus musculus Q91VN6
Confocal
23142775
Intra
Sting1 Q3TBT3 Igf2r Mus musculus Q07113
Anti Bait CoIP
37863414
Intra
Sting1 Q3TBT3 Tbk1 Mus musculus Q9WUN2
Anti Bait CoIP
22000020
Intra
Sting1 Q3TBT3 Tbk1 Mus musculus Q9WUN2
Anti Bait CoIP
23142775
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-112906 C-176 Inhibitor 99.22% Unkown
HY-114399 STING ligand-1 99.65% Unkown
HY-138683 STING-IN-3 Inhibitor 99.75% Unkown
HY-12885C 2’3’-c-di-AM(PS)2 (Rp,Rp) enantiomer ammonium salt Inducer 98.94% Unkown
HY-RS13916 STING1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13917 Sting1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13918 Sting1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-163643 STING modulator-7 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sting1 NCBI NCBI:340061