ZNF185 - zinc finger protein 185 with LIM domain Gene

Also Known as SCELL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7739

About ZNF185

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,898,067-152,973,481 (from NCBI)

This gene has 11 transcripts (splice variants), 149 orthologues and 1 paralogue. Biased expression in esophagus (RPKM 112.2), skin (RPKM 20.8) and 4 other tissues.

Summary

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and Apoptosis. This gene encodes a LIM-domain Zinc Finger Protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

ZNF185 Products (10)

mRNA	Protein	Name
NM_001178106.1	NP_001171577.1	zinc finger protein 185 isoform 1
NM_001178107.1	NP_001171578.1	zinc finger protein 185 isoform 2
NM_001178108.2	NP_001171579.1	zinc finger protein 185 isoform 3
NM_001178109.1	NP_001171580.1	zinc finger protein 185 isoform 5
NM_001178110.1	NP_001171581.1	zinc finger protein 185 isoform 6
NM_001178113.2	NP_001171584.1	zinc finger protein 185 isoform 7
NM_001178115.2	NP_001171586.1	zinc finger protein 185 isoform 9
NM_001388432.2	NP_001375361.1	zinc finger protein 185 isoform 3
NM_001395254.1	NP_001382183.1	zinc finger protein 185 isoform 10
NM_007150.3	NP_009081.2	zinc finger protein 185 isoform 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
zinc finger protein 185	P1-A

ZNF185 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNF185	O15231	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	ZNF185	O15231	LMO2	Homo sapiens	P25791-3	Validated Y2H	32296183
Intra	ZNF185	O15231	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	ZNF185	O15231	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	ZNF185	O15231	PRR23B	Homo sapiens	Q6ZRT6	Validated Y2H	32296183
Intra	ZNF185	O15231	HSF2BP	Homo sapiens	O75031	Validated Y2H	32296183
Intra	ZNF185	O15231	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	ZNF185	O15231	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	ZNF185	O15231	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	ZNF185	O15231	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	ZNF185	O15231	AARSD1	Homo sapiens	Q9BTE6-2	Y2H Prey Pooling	32296183
Intra	ZNF185	O15231	AARSD1	Homo sapiens	Q9BTE6-2	Validated Y2H	32296183
Intra	ZNF185	O15231	AARSD1	Homo sapiens	Q9BTE6-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Mast Cell Neoplasm	Mastocytoma Mast Cell Proliferative Disease Mast Cell Tumor Benign Mastocytoma
Intussusception	Intussusception Of Intestine Invagination Of Intestine Or Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16107	ZNF185 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ZNF185	VGNC	VGNC:48670
Rattus norvegicus	ZNF185	RGD	RGD:1586351
Mus musculus	ZNF185	MGD	MGI:108095
Bos taurus	ZNF185	VGNC	VGNC:37219
Felis catus	ZNF185	VGNC	VGNC:67273
Others	ZNF185	NCBI