LIN28A - lin-28 homolog A Gene

Also Known as CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79727

About LIN28A

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,410,817-26,429,728 (from NCBI)

This gene has 2 transcripts (splice variants), 303 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 1.6).

Summary

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of MicroRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with Cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

LIN28A Products (1)

mRNA	Protein	Name
NM_024674.6	NP_078950.1	protein lin-28 homolog A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19703396	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21247876	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	21247876	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19703396	GOA
enables protein-RNA adaptor activity	IDA IDA: Inferred from direct assay	18951094	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in miRNA catabolic process	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in negative regulation of pre-miRNA processing	IDA IDA: Inferred from direct assay	21247876	GOA
involved in positive regulation of cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	21247876	GOA
involved in pre-miRNA processing	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19703396	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	17617744	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18604195	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	17617744	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17617744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN28A Protein Structure

CSD

zf-CCHC

0
100
209 a.a.

Protein Preferred Names	Protein Names
protein lin-28 homolog A	RNA-binding protein LIN-28

LIN28A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LIN28A	Q9H9Z2	ZNF275	Homo sapiens	Q9NSD4	Validated Y2H	32296183
Intra	LIN28A	Q9H9Z2	ZNF275	Homo sapiens	Q9NSD4	Y2H Array	32296183
Intra	LIN28A	Q9H9Z2	ZNF275	Homo sapiens	Q9NSD4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

LIN28A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80210	LIN28A Antibody (YA710)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P80744	LIN28A Antibody (YA711)	WB	Human, Mouse
HY-P80744A	LIN28A Antibody (YA711)(PBS only)	WB	Human, Mouse
HY-P81728	LIN28A Antibody (YA1473)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P85258	LIN28A Antibody (YA4950)	WB; IHC-P; IHC-F; ICC/IF; IF-Tissue; IP; FC	Human
HY-P85574	LIN28A Antibody (YA5266)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Medulloepithelioma	Diktyoma, Malignant Medulloepithelioma, Central Nervous System Medulloepithelioma Of The Central Nervous System
Central Nervous System Primitive Neuroectodermal Neoplasm	Cpnet
Embryonal Tumor With Multilayered Rosettes, C19mc-Altered	Ependymoblastoma
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Perlman Syndrome	Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor PRLMNS Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome Renal Hamartomas Nephroblastomatosis And Fetal Gigantism Nephroblastoma Fetal Macrosomia
Acrocephalopolysyndactyly Type Iii	Sakati Syndrome Sakati-Nyhan Syndrome Acps With Leg Hypoplasia Acps Iii Acrocephalopolysyndactyly Type 3 Sakati-Nyhan-Tisdale Syndrome
Inflammatory Bowel Disease 7	IBD7
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Atypical Teratoid Rhabdoid Tumor	Rhabdoid Tumor Predisposition Syndrome Rtps Atypical Teratoid/Rhabdoid Tumor Rhabdoid Predisposition Syndrome Familial Posterior Fossa Brain Tumor Of Infancy Familial Rhabdoid Tumor At/Rt Atypical Teratoid Rhabdoid Tumour Atypical Teratoid/Rhabdoid Tumour Rhabdoid Tumor Of The Cns Rhabdoid Tumour Of The Cns Familial Posterior Fossa Brain Tumor Syndrome Hereditary Swi/Snf Deficiency Syndrome Atrt
Mature Teratoma	Dermoid Cyst Benign Teratoma
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Retinitis Pigmentosa 50	RP50 Retinitis Pigmentosa, Concentric Retinitis Pigmentosa-50 Retinitis Pigmentosa Concentric
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168437	LIN28-IN-2		99.51%	Unkown
HY-112659	Lin28-let-7 antagonist 1	Antagonist	99.43%	Unkown
HY-100692	Lin28-let-7a antagonist 1	Antagonist	99.57%	Unkown
HY-168346	TS-002455		/	Unkown
HY-177782	SB1349	Degrader	/	Unkown
HY-RS07671	LIN28A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174590	Human LIN28A mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LIN28A	VGNC	VGNC:42683
Felis catus	LIN28A	VGNC	VGNC:63231
Mus musculus	LIN28A	MGD	MGI:1890546
Rattus norvegicus	LIN28A	RGD	RGD:1566408
Others	LIN28A	NCBI