Prmt6 - protein arginine N-methyltransferase 6 Gene

Also Known as Hrmt1l6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 99890

About Prmt6

Chromosome 3: 110,153,425-110,158,314 reverse strand.GRCm39:CM000996.3

This gene has 3 transcripts (splice variants), 166 orthologues, 7 paralogues and is associated with 11 phenotypes. Ubiquitous expression in ovary adult (RPKM 8.9), adrenal adult (RPKM 6.9) and 28 other tissues.

Summary

Enables chromatin binding activity and histone-arginine N-methyltransferase activity. Involved in peptidyl-arginine N-methylation. Acts upstream of or within several processes, including cellular senescence; histone H3-R2 methylation; and negative regulation of nitrogen compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Is expressed in central nervous system and sensory organ. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]

Prmt6 Products (1)

mRNA Protein Name
NM_178891.5 NP_849222.3 protein arginine N-methyltransferase 6

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
22904064 MGI
enables histone H3R2 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
22904064 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26070566 MGI
enables protein-arginine N-methyltransferase activity IDA
IDA: Inferred from direct assay
18495660 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular senescence IMP
IMP: Inferred from mutant phenotype
22904064 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22904064 MGI
involved in negative regulation of ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
26070566 MGI
acts upstream of or within regulation of signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
22904064 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt6 Protein Structure

AdoMet_MTases

AdoMet_MTases: cd02440 (87 - 187)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

protein arginine N-methyltransferase 6

  • HMT1 hnRNP methyltransferase-like 6

  • histone-arginine N-methyltransferase PRMT6

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-128717A GSK3368715 dihydrochloride Inhibitor 99.96% Phase 1
HY-128717B GSK3368715 trihydrochloride Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19615 MS023 Inhibitor 99.93% Unkown
HY-114965 TP-064 Inhibitor 99.29% Unkown
HY-12970 EPZ020411 Inhibitor 98.07% Unkown
HY-12970A EPZ020411 hydrochloride Inhibitor 98.15% Unkown
HY-128717 GSK3368715 Inhibitor 99.41% Unkown
HY-19615B MS023 dihydrochloride Inhibitor 99.68% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-133740 MS117 Inhibitor 98.0% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-178114 SKLB-0124 Degrader / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-175821 PRMT1-IN-3 Inhibitor / Unkown
HY-186045 SKLB06489 Inhibitor / Unkown
HY-178274 SKLB06329 Inhibitor / Unkown
HY-12970B EPZ020411 dihydrochloride Inhibitor / Unkown
HY-161334 CARM1-IN-4 Inhibitor / Unkown
HY-146810 PRMT4-IN-1 Inhibitor / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prmt6 NCBI NCBI:55170