GePhos1
Based on 1 publication(s) in Google Scholar
GePhos1, a EGFR-targeting PhosTAC (phosphorylation targeting chimera), induces EGFR dephosphorylation. GePhos1 induces apoptosis.
For research use only. We do not sell to patients.
- Purity: 98.88%
- Formula: C63H75ClFN7O13
- Molecular Weight:1192.76
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) GePhos1
MoreAll EGFR Isoforms
More
Biological Activity
GePhos1 displays profound EGFR dephosphorylation at both EGFR pY1068, which is one of the major EGFR autophosphorylation sites, and at pY845, a key site within the kinase loop[1].
GePhos1 (1 μM) induces apoptosis and cell death in HeLa cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Appearance Solid
-
Molecular Weight 1192.76
-
Formula C63H75ClFN7O13
-
Color White to off-white
-
SMILES
COC1=C(OC)C=CC(CC[C@H](C2=CC(OCC(NCCC(N3CCN(CCCOC4=CC5=C(NC6=CC=C(F)C(Cl)=C6)N=CN=C5C=C4OC)CC3)=O)=O)=CC=C2)OC([C@@H]7CCCCN7C([C@@H](CC)C8=CC(OC)=C(OC)C(OC)=C8)=O)=O)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)