1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Glibornuride

Glibornuride 

Cat. No.: HY-17451
Handling Instructions

Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75. Antidiabetic agent.

For research use only. We do not sell to patients.

Glibornuride Chemical Structure

Glibornuride Chemical Structure

CAS No. : 26944-48-9

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Description

Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75[1]. Antidiabetic agent[2].

IC50 & Target

pKi: 5.75 (KATP channel)[1]

In Vivo

Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) for 28 days causes an increase in body weights in the diabetic groups in Swiss albino rats[2].
Treatment with Glibornuride for 28 days decreases the serum uric acid levels in diabetic rats[2].
Administration of Glibornuride for 28 days, insignificantly increases the liver lipid peroxidation levels in diabetic rats[2].

Animal Model: 6-6.5-month-old male Swiss Albino rats, weighing 150-200 g[2]
Dosage: 5 mg/kg
Administration: Given by gavage, daily for 28 days
Result: Administration for 28 days caused an increase in body weights in the diabetic groups.
Treatment for 28 days decreased the serum uric acid levels in diabetic rats.
Molecular Weight

366.48

Formula

C₁₈H₂₆N₂O₄S

CAS No.

26944-48-9

SMILES

O=S(C1=CC=C(C)C=C1)(NC(N[[email protected]]2[[email protected]@](C3(C)C)([H])CC[[email protected]@]3(C)[[email protected]]2O)=O)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GlibornuridePotassium ChannelKcsAParsleyStreptozotocinblocker ATPsensitiveK channelAntidiabeticInhibitorinhibitorinhibit

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Glibornuride
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HY-17451
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