1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Glibornuride

Glibornuride 

Cat. No.: HY-17451 Purity: 99.25%
COA Handling Instructions

Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75. Antidiabetic agent.

For research use only. We do not sell to patients.

Glibornuride Chemical Structure

Glibornuride Chemical Structure

CAS No. : 26944-48-9

Size Price Stock Quantity
5 mg USD 230 In-stock
Estimated Time of Arrival: December 31
10 mg USD 370 In-stock
Estimated Time of Arrival: December 31
25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75[1]. Antidiabetic agent[2].

IC50 & Target

pKi: 5.75 (KATP channel)[1]

In Vivo

Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) for 28 days causes an increase in body weights in the diabetic groups in Swiss albino rats[2].
Treatment with Glibornuride for 28 days decreases the serum uric acid levels in diabetic rats[2].
Administration of Glibornuride for 28 days, insignificantly increases the liver lipid peroxidation levels in diabetic rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-6.5-month-old male Swiss Albino rats, weighing 150-200 g[2]
Dosage: 5 mg/kg
Administration: Given by gavage, daily for 28 days
Result: Administration for 28 days caused an increase in body weights in the diabetic groups.
Treatment for 28 days decreased the serum uric acid levels in diabetic rats.
Molecular Weight

366.48

Formula

C18H26N2O4S

CAS No.
SMILES

O=S(C1=CC=C(C)C=C1)(NC(N[[email protected]]2[[email protected]@](C3(C)C)([H])CC[[email protected]@]3(C)[[email protected]]2O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (682.17 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7287 mL 13.6433 mL 27.2866 mL
5 mM 0.5457 mL 2.7287 mL 5.4573 mL
10 mM 0.2729 mL 1.3643 mL 2.7287 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.68 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Glibornuride
Cat. No.:
HY-17451
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