1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Glibornuride


Cat. No.: HY-17451
Handling Instructions

Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75. Antidiabetic agent.

For research use only. We do not sell to patients.

Glibornuride Chemical Structure

Glibornuride Chemical Structure

CAS No. : 26944-48-9

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Glibornuride is a blocker of ATP-sensitive K+ channels (KATP channel) with a pKi of 5.75[1]. Antidiabetic agent[2].

IC50 & Target

pKi: 5.75 (KATP channel)[1]

In Vivo

Administration of Glibornuride (5 mg/kg; gavage, daily for 28 days) for 28 days causes an increase in body weights in the diabetic groups in Swiss albino rats[2].
Treatment with Glibornuride for 28 days decreases the serum uric acid levels in diabetic rats[2].
Administration of Glibornuride for 28 days, insignificantly increases the liver lipid peroxidation levels in diabetic rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-6.5-month-old male Swiss Albino rats, weighing 150-200 g[2]
Dosage: 5 mg/kg
Administration: Given by gavage, daily for 28 days
Result: Administration for 28 days caused an increase in body weights in the diabetic groups.
Treatment for 28 days decreased the serum uric acid levels in diabetic rats.
Molecular Weight







O=S(C1=CC=C(C)C=C1)(NC(N[[email protected]]2[[email protected]@](C3(C)C)([H])CC[[email protected]@]3(C)[[email protected]]2O)=O)=O


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GlibornuridePotassium ChannelKcsAParsleyStreptozotocinblocker ATPsensitiveK channelAntidiabeticInhibitorinhibitorinhibit

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