GQN-B37-Me
GQN-B37-Me is a MCL-1 inhibitor. GQN-B37-Me induces caspase-dependent apoptosis. GQN-B37-Me exhibits noteworthy cytotoxicity in H929 (IC50 = 3.71 μM) and MV-4-11 (IC50 = 5.57 μM) cells. GQN-B37-Me can be used for the research of leukemia.
For research use only. We do not sell to patients.
- Formula: C30H25ClN4O4
- Molecular Weight:541.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MCL-1[1]
GQN-B37-Me (1-20 μM, 24 h) induces late apoptosis in MV-4-11 cells in a clear dose-dependent manner[1].
GQN-B37-Me (10-40 μM, 10 h) is able to block the MCL-1/BIM interaction in H929 cells and consequently induces caspase-dependent apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 541.00
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Formula C30H25ClN4O4
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SMILES
O=C(O)[C@H](CC1=CNC2=CC=CC=C12)N(C)C(/C=C/C3=CN(C4=CC=CC(Cl)=C4)N=C3C5=CC=C(O)C=C5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GQN-B37-Me Related Classifications
HY-161733 Related Classifications
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