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GRP-60367 hydrochloride 

Cat. No.: HY-133735A
Handling Instructions

GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein.

For research use only. We do not sell to patients.

GRP-60367 hydrochloride Chemical Structure

GRP-60367 hydrochloride Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of GRP-60367 hydrochloride:

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Description

GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1].

IC50 & Target

RABV[1]

In Vitro

GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: BEAS-2B, 293T, or Hep-2 cell lines
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1000 μM
Incubation Time: 48 hours
Result: EC50s of 2 nM, 3 nM, and 52 nM for RABV-ΔG-nanoLuc virus in BEAS-2B, 293T, or Hep-2 cell lines, respectively.
Molecular Weight

389.92

Formula

C₂₁H₂₈ClN₃O₂

SMILES

CC1=C(OCCNC2CCN(C(C3=CC=NC=C3)=O)CC2)C=C(C)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (641.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5646 mL 12.8231 mL 25.6463 mL
5 mM 0.5129 mL 2.5646 mL 5.1293 mL
10 mM 0.2565 mL 1.2823 mL 2.5646 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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Keywords:

GRP-60367GRP60367GRP 60367OthersrabiesvirusRABVentrystrainInhibitorinhibitorinhibit

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Product Name:
GRP-60367 hydrochloride
Cat. No.:
HY-133735A
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