GSK 1997132B
GSK 1997132B is a benzimidazole-based PPARγ partial agonist that can cross the blood-brain barrier with a pEC50 value of 8.0. GSK 1997132B has no significant effect on PPARα/δ. GSK 1997132B improves the problem of high blood clearance rate of earlier compounds, avoiding side effects such as weight gain and edema. GSK 1997132B can be used for research on Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 1168138-37-1
- Formula: C24H22F2N4O
- Molecular Weight:420.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
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PPAR-γ 8 (pEC50) |
Chemical Information
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CAS No. 1168138-37-1
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Molecular Weight 420.45
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Formula C24H22F2N4O
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SMILES
O=C(N[C@H](CC)C1=CC=CC=C1)C2=CC=C3N(C(C)=NC3=C2)CC4=NC=C(C=C4F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Sime M, et al. Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5568-72. doi: 10.1016/j.bmcl.2011.06.088. Epub 2011 Jun 29. Erratum in: Bioorg Med Chem Lett. 2013 Feb 15;23(4):1143. Wilson, Timothy M [corrected to Willson, Timothy M]. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK 1997132B Related Classifications
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